Salvinorin A: Difference between revisions

Salvinorin A is a potent [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor [[agonist]]. It does not have any effect on the 5-HT_2A receptor, the receptor targeted by most [[psychedelic]] substances, nor does it act as an NMDA receptor antagonist as dissociatives do. The unique structure of salvinorin A lacks features commonly associated with opioid ligand binding such as a guaternary carbon atom linked to a tertiary amine group by two other carbon atoms. Unlike traditional opioid agonists, salvinorin A targets the [[Opioid#Kappa_.28.CE.BA.29|κ-opioid]] receptor rather than the [[Opioid#Mu_.28.CE.BC.29|μ-opioid]] receptor.

==Subjective effects==

{{Preamble/SubjectiveEffects}}

{{effects/base

|{{effects/physical|

*'''[[Effect::Changes in felt gravity]]''' - The most prominent physical sensation of a salvinorin A trip is known by many people as “salvia gravity.” This is at least partially present during the mildest of trips and increases proportionally with dose until it is all-encompassing. It begins with a heavy sensation that pulls and tugs at the body. As this increases, it inevitably becomes so powerful that it swiftly lifts the user up and out of their body at extremely high speeds and over vast distances in a direction that often doesn't quite make sense. This feels as if the user is being pushed or pulled into a space vastly different from anything found on the classic hallucinogens.

*'''[[Effect::Changes in felt bodily form]]''' - This effect often accompanies the onset of powerful salvinorin A gravity and can be described as non-painful sensations of being stretched horizontally or vertically into infinity, splitting into two halves, and a variety of other sudden changes. This can even include the user feeling as if they have actually become an inanimate object within their current setting.   

*'''[[Effect::Spatial disorientation]]'''

*'''[[Effect::Motor control loss]]'''

}}

{{effects/transpersonal|

*'''[[Effect::Spirituality enhancement]]'''

*'''[[Effect::Unity and interconnectedness]]'''

}}

[[File:Salvia Recognita.jpg|thumb|Salvia Recognita]]

==Classification==

Although salvia shares states of hallucinatory structures and out-of-body experiences commonly reported with typical dissociatives ([[NMDA receptor antagonist]]s), this is arguably not sufficient so that it falls under the same classification. For example, the hallucinatory structures (although similar) are vastly different in their style and complexity. Alongside of this, the out-of-body experiences commonly reported with dissociatives are presumed to be triggered by the way in which NMDA receptor antagonists block signals to the conscious mind from other parts of the brain. This is accompanied by a distinctive feeling of dissociation, disconnection and detachment which is not present on salvia as it works on an entirely different set of receptors, the function of which in the human brain is almost entirely unknown.{{citation needed}}

==Research==

==Toxicity and harm potential==

{{toxicity}}

The toxicity and long-term health effects of recreational salvinorin A use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because salvinorin A is a [[research chemical]] with very little history of human usage.  

*'''Croatia:''' Salvinorin A is illegal to possess and sell in Croatia.{{citation needed}}

*'''Czech Republic:''' Salvinorin A is illegal to possess and sell in Czech Republic.{{citation needed}}

*'''Denmark:''' Salvinorin A is a Class B drug in Denmark.{{citation needed}}

*'''Ireland:''' Salvinorin A is illegal to possess and sell in Ireland.{{citation needed}}

*'''Italy:''' Salvinorin A is illegal to possess and sell in Italy.{{citation needed}}

*'''Sweden:''' Salvinorin A is illegal to possess and sell in Sweden.{{citation needed}}

*'''Switzerland''': Salvia divinorum as well as Salvinorin A are controlled substances specifically named under Verzeichnis D.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>

*'''United States:''' Salvinorin A is illegal in certain states.{{citation needed}}

*[https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=4823 Salvinorin Analogues; Beyond Salvinorin A (DMT Nexus)]

==Literature==

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