Template:BenzoOD: Difference between revisions

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Benzodiazepine overdose may occur when ~~a [[benzodiazepine]]~~ is taken ~~in extremely heavy quantities or concurrently~~ with other [[depressants]]. This is ~~particularly dangerous~~ with other [[GABA|GABAergic]] depressants such as [[barbiturate|barbiturates]] and [[alcohol]] since they work in a similar fashion, but bind to distinct ~~allosteric~~ sites on the GABAA receptor, cross-~~potentiating each other~~.{{citation needed}}

Benzodiazepine overdose may occur with extremely high doses or, more commonly, when it is taken with other [[depressants]]. This risk is especially present with other [[GABA|GABAergic]] depressants, such as [[barbiturate|barbiturates]] and [[alcohol]], since they work in a similar fashion but bind to distinct sites on the GABAA receptor, resulting in significant cross-potentiation.{{citation needed}}

~~For example~~, benzodiazepines increase the frequency in which the chlorine ion pore opens on the GABAA receptor while barbiturates increase the duration in which they are open, meaning when both are consumed, the ion pore will open more frequently and stay open longer.~~<ref>Twyman~~, ~~R. E.~~, ~~Rogers~~, ~~C. J., & Macdonald~~, ~~R. L. (1989). Differential regulation of γ‐aminobutyric acid receptor channels by diazepam~~ and ~~phenobarbital. ''Annals of Neurology'', 25(3), 213~~-~~220~~. ~~https://doi~~.~~org/10.1002/ana.410250302</ref> This can result in dangerously disinhibited~~, ~~total blackout states along~~ with ~~potential lethal respiratory depression~~.~~{{citation needed}}~~

Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly. Symptoms may include severe [[language suppression|slurred speech]], [[confusion]], [[delusions]], [[respiratory depression]], and non-responsiveness. The user might seem like they are sleepwalking. The user is also more susceptible to consume more of the same or another substance due to their impaired judgement, which is typically not seen with other substances during overdose.

~~Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly.~~

Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Care is primarily supportive in nature, although overdoses are sometimes treated with [[flumazenil]], a GABAA antagonist<ref>{{cite journal | vauthors=((Hoffman, E. J.)), ((Warren, E. W.)) | journal=Clinical Pharmacy | title=Flumazenil: a benzodiazepine antagonist | volume=12 | issue=9 | pages=641–656; quiz 699–701 | date= September 1993 | issn=0278-2677}}</ref> or additional procedures such as [[adrenaline]] injections if other substances are involved.{{citation needed}}

~~Symptoms of a benzodiazepine overdose may include severe [[thought deceleration]], [[language suppression|slurred speech]], [[confusion]], [[delusions]], [[respiratory depression]], coma or death.~~ Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. ~~Benzodiazepine~~ overdoses are sometimes treated with [[flumazenil]], a GABAA antagonist,<ref>~~Amrein~~, R.~~, Leishman, B~~., ~~Bentzinger~~, C.~~, & Roncari, G~~. ~~(1987~~). Flumazenil in benzodiazepine ~~antagonism. ''Medical Toxicology and Adverse Drug Experience'', 2(6), 411~~-~~429. PMID: 8306565~~</ref> ~~however, care is primarily supportive in nature~~.

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-Benzodiazepine overdose may occur when a [[benzodiazepine]] is taken in extremely heavy quantities or concurrently with other [[depressants]]. This is particularly dangerous with other [[GABA|GABAergic]] depressants such as [[barbiturate|barbiturates]] and [[alcohol]] since they work in a similar fashion, but bind to distinct allosteric sites on the GABA<sub>A</sub> receptor, cross-potentiating each other.{{citation needed}}
+Benzodiazepine overdose may occur with extremely high doses or, more commonly, when it is taken with other [[depressants]]. This risk is especially present with other [[GABA|GABAergic]] depressants, such as [[barbiturate|barbiturates]] and [[alcohol]], since they work in a similar fashion but bind to distinct sites on the GABA<sub>A</sub> receptor, resulting in significant cross-potentiation.{{citation needed}}
-For example, benzodiazepines increase the frequency in which the chlorine ion pore opens on the GABA<sub>A</sub> receptor while barbiturates increase the duration in which they are open, meaning when both are consumed, the ion pore will open more frequently and stay open longer.<ref>Twyman, R. E., Rogers, C. J., & Macdonald, R. L. (1989). Differential regulation of γ‐aminobutyric acid receptor channels by diazepam and phenobarbital. ''Annals of Neurology'', 25(3), 213-220. https://doi.org/10.1002/ana.410250302</ref> This can result in dangerously disinhibited, total blackout states along with potential lethal respiratory depression.{{citation needed}}
+Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly. Symptoms may include severe [[language suppression|slurred speech]], [[confusion]], [[delusions]], [[respiratory depression]], and non-responsiveness. The user might seem like they are sleepwalking. The user is also more susceptible to consume more of the same or another substance due to their impaired judgement, which is typically not seen with other substances during overdose.
-Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly.
+Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Care is primarily supportive in nature, although overdoses are sometimes treated with [[flumazenil]], a GABA<sub>A</sub> antagonist<ref>{{cite journal | vauthors=((Hoffman, E. J.)), ((Warren, E. W.)) | journal=Clinical Pharmacy | title=Flumazenil: a benzodiazepine antagonist | volume=12 | issue=9 | pages=641–656; quiz 699–701 | date= September 1993 | issn=0278-2677}}</ref> or additional procedures such as [[adrenaline]] injections if other substances are involved.{{citation needed}}
-Symptoms of a benzodiazepine overdose may include severe [[thought deceleration]], [[language suppression|slurred speech]], [[confusion]], [[delusions]], [[respiratory depression]], coma or death. Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Benzodiazepine overdoses are sometimes treated with [[flumazenil]], a GABA<sub>A</sub> antagonist,<ref>Amrein, R., Leishman, B., Bentzinger, C., & Roncari, G. (1987). Flumazenil in benzodiazepine antagonism. ''Medical Toxicology and Adverse Drug Experience'', 2(6), 411-429. PMID: 8306565</ref> however, care is primarily supportive in nature.