Kavain: Difference between revisions

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'''Kavain''' is the main [[kavalactone]] found mostly in the [[Root|roots]] of the [[kava]] plant.

Kavain has [[anticonvulsive]] properties, attenuating [[vascular]] [[Smooth muscle|smooth muscle]] contraction through interactions with voltage-dependent [[Sodium channel|Na+]] and Ca<sup>2+</sup>channels. How this effect is mediated and to what extent this mechanism is involved in the [[anxiolytic]]<nowiki/>and [[analgesic]] effects of kavalactones on the [[Central nervous system|central nervous system]] is unknown. The recent finding that kavain can [[Monoamine oxidase inhibitor|reversibly inhibit]] both [[Monoamine oxidase A|monoamine oxidase A]] and [[Monoamine oxidase B|monoamine oxidase B]] suggests that kavain may exert some of its effects by modulating [[serotonin]], [[norepinephrine]], and [[dopamine]] signaling.

Revision as of 22:45, 28 May 2022 view source >Ohwun Created page with "Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Sodium channel\|Na+..."		Latest revision as of 22:47, 28 May 2022 view source >Ohwun mNo edit summary
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			'''Kavain''' is the main [[kavalactone]] found mostly in the [[Root\|roots]] of the [[kava]] plant.

	Kavain has [[anticonvulsive]] properties, attenuating [[vascular]] [[Smooth muscle\|smooth muscle]] contraction through interactions with voltage-dependent [[Sodium channel\|Na+]] and Ca<sup>2+</sup>channels. How this effect is mediated and to what extent this mechanism is involved in the [[anxiolytic]]<nowiki/>and [[analgesic]] effects of kavalactones on the [[Central nervous system\|central nervous system]] is unknown. The recent finding that kavain can [[Monoamine oxidase inhibitor\|reversibly inhibit]] both [[Monoamine oxidase A\|monoamine oxidase A]] and [[Monoamine oxidase B\|monoamine oxidase B]] suggests that kavain may exert some of its effects by modulating [[serotonin]], [[norepinephrine]], and [[dopamine]] signaling.		Kavain has [[anticonvulsive]] properties, attenuating [[vascular]] [[Smooth muscle\|smooth muscle]] contraction through interactions with voltage-dependent [[Sodium channel\|Na+]] and Ca<sup>2+</sup>channels. How this effect is mediated and to what extent this mechanism is involved in the [[anxiolytic]]<nowiki/>and [[analgesic]] effects of kavalactones on the [[Central nervous system\|central nervous system]] is unknown. The recent finding that kavain can [[Monoamine oxidase inhibitor\|reversibly inhibit]] both [[Monoamine oxidase A\|monoamine oxidase A]] and [[Monoamine oxidase B\|monoamine oxidase B]] suggests that kavain may exert some of its effects by modulating [[serotonin]], [[norepinephrine]], and [[dopamine]] signaling.