Ergot: Difference between revisions

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[[File:Ergot Fungus On Rye.jpg|alt=Ergot Fungus On Rye|thumb|https://cdn-a.william-reed.com/var/wrbm_gb_food_pharma/storage/images/publications/feed/feednavigator.com/news/suppliers/ergot-presence-in-feed-crops-a-concern-in-the-us/10247607-1-eng-GB/Ergot-presence-in-feed-crops-a-concern-in-the-US_wrbm_large.jpg]]

'''Ergot''' is a ~~fungus that grows on Rye and Heather~~.

'''Ergot''' or '''ergot fungi''' refers to a group of fungi of the genus '''''Claviceps'''''.

Ergot is the main source of [[~~Ergotamine~~]] and is an ingredient in many [[~~Lysergamides~~]].

The most prominent member of this group is ''Claviceps purpurea'' ("rye ergot fungus"). This fungus grows on rye and related plants, and produces [[Alkaloid|alkaloids]] that can cause ergotism in humans and other mammals who consume grains contaminated with its fruiting structure (called ergot sclerotium).<ref>[http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/three/000036589.htm ergot] {{webarchive|url=https://web.archive.org/web/20090910032206/http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=%2Fppdocs%2Fus%2Fcommon%2Fdorlands%2Fdorland%2Fthree%2F000036589.htm |date=September 10, 2009}}, Dorland's Medical Dictionary</ref>

Ergot is the main source of [[ergotamine]] and is an ingredient in many [[lysergamides]].

<br />

==History==

==History and culture==

~~In 944 A~~.D. in ~~Paris~~, ~~France~~, the ~~average population would consume rye bread daily for food~~. ~~A particular incident~~ in which the ~~rye bread started to go bad~~, ~~and~~ the ~~population did not notice~~. ~~People were buying~~ and ~~serving~~ rye bread infected ~~with~~ the ~~ergot fungus~~. On a ~~particular night~~ in ~~mid 944 A~~.D. ~~people~~ in ~~Paris were enjoying dinner~~ and ~~drinking lightly~~. ~~Around two hours later~~, ~~people were in~~ the ~~streets considered~~ to ~~be mad~~. ~~Half~~ of ~~the population~~ of ~~Paris died over~~ the ~~course~~ of ~~a few days of absolute insanity~~. ~~This incident is referred to as the Ergot epidemic; the term~~ "~~Werewolf~~" ~~derives from people who had ingested ergot infected bread~~.

Ergotism is the earliest recorded example of ''mycotoxicosis'', or poisoning caused by toxic molds.<ref name="Bennett Bentley 1999 Story Ergot">{{cite journal |last1=Bennett |first1=J.W. |last2=Bentley |first2=Ronald |title=Pride and Prejudice: The Story of Ergot |journal=Perspectives in Biology and Medicine |volume=42 |issue=3 |pages=333–355 |doi=10.1353/pbm.1999.0026|year=1999}}</ref>

Early references to ergotism date back as far as 600 BC, an Assyrian tablet referred to it as a 'noxious pustule in the ear of grain'.<ref name="Ergot:from witchcraft to biotechnology">{{cite journal |last1=Haarmann |first1=Thomas |last2=Rolke |first2=Yvonne |last3=Giesbert |first3=Sabine |last4=Tudzynski |first4=Paul |title=Ergot:from witchcraft to biotechnology |journal=Molecular Plant Pathology |date=2009 |volume=10 |issue=4 |pages=563–77 |doi=10.1111/J.1364-3703.2009.00548.X |pmid=19523108 |pmc=6640538}}</ref> In 350 BC, the Parsees described 'noxious grasses that cause pregnant women to drop the womb and die in childbed'.<ref name="Ergot:from witchcraft to biotechnology" />

In ancient Syria, ergot was called 'Daughter of Blood'.<ref name="Wellcome" /> Radulf Glaber described an ailment he called 'hidden fire' or ''ignus ocultus'', in which a burning of the limb is followed by its separation from the body, often consuming the victim in one night.<ref name="Wellcome" /> In 1588, Johannes Thallius wrote that it is called 'Mother of Rye', or ''rockenmutter'', and is used to halt bleeding.<ref name="Wellcome" />

Human poisoning due to the consumption of rye bread made from ergot-infected grain was common in Europe in the Middle Ages. The first mention of a plague of gangrenous ergotism in Europe comes from Germany in 857, following this France and Scandinavia experienced similar outbreaks;<ref name="De Costa">{{cite journal |last1=De Costa |first1=Caroline |title=StAnthony's fire and living ligatures: a short history of ergometrine |journal=The Lancet |date=May 18, 2002 |volume=359 |issue=9319 |pages=1768–1770 |doi=10.1016/S0140-6736(02)08658-0 |pmid=12049883}}</ref> England is noticeably absent from the historical regions affected by ergotism as their main source of food was wheat, which is resistant to ergot fungi.<ref name="Wellcome">{{cite book |last1=Wellcome |first1=Henry S. |last2=Solomon |first2=Henry |title=From Ergot to Ernutin |date=June 19, 1908 |publisher=Canadian Medical Association |location=Ottawa |isbn=978-1331946151 |pages=1–60}}</ref>

In 944, a massive outbreak of ergotism caused 40,000 deaths in the regions of Aquitaine, Limousin, Perigord, and Angoumois in France.<ref name="Bennett Bentley 1999 Story Ergot" /> In Hesse in 1596, Wendelin Thelius was one of the first to attribute ergotism poisoning to grain.<ref name="De Costa" /> In 1778, S. Tessier, observing a huge epidemic in Sologne, France in which more than 8,000 people died, recommended drainage of fields, compulsory cleaning of grain, and the substitution of potatoes for affected grain.<ref name="De Costa" />

==Chemistry==

==Pharmacology==

==External links==

*[https://en.wikipedia.org/wiki/Ergot Ergot (Wikipedia)]

==See also==

*[[Lysergamides]]

*[[LSA]]

*[[LSD]]

==~~Consumption~~==

==References==

Consumption of the ergot fungus right off of the rye stalk is an absolutely terrible idea. This will cause Ergotism and you will suffer the same fate as the many people in Paris. No one should consume this fungus, as it will most definitely kill you.

~~[[Category:Stub]]~~

@@ Line 1: / Line 1: @@
+{{headerpanel|{{stub}}}}
 [[File:Ergot Fungus On Rye.jpg|alt=Ergot Fungus On Rye|thumb|https://cdn-a.william-reed.com/var/wrbm_gb_food_pharma/storage/images/publications/feed/feednavigator.com/news/suppliers/ergot-presence-in-feed-crops-a-concern-in-the-us/10247607-1-eng-GB/Ergot-presence-in-feed-crops-a-concern-in-the-US_wrbm_large.jpg]]
-'''Ergot''' is a fungus that grows on Rye and Heather.
+'''Ergot''' or '''ergot fungi''' refers to a group of fungi of the genus '''''Claviceps'''''.
-Ergot is the main source of [[Ergotamine]] and is an ingredient in many [[Lysergamides]].
+The most prominent member of this group is ''Claviceps purpurea'' ("rye ergot fungus"). This fungus grows on rye and related plants, and produces [[Alkaloid|alkaloids]] that can cause ergotism in humans and other mammals who consume grains contaminated with its fruiting structure (called ergot sclerotium).<ref>[http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/three/000036589.htm ergot] {{webarchive|url=https://web.archive.org/web/20090910032206/http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=%2Fppdocs%2Fus%2Fcommon%2Fdorlands%2Fdorland%2Fthree%2F000036589.htm |date=September 10, 2009}}, Dorland's Medical Dictionary</ref>
+Ergot is the main source of [[ergotamine]] and is an ingredient in many [[lysergamides]].
 <br />
-==History==
+==History and culture==
-In 944 A.D. in Paris, France, the average population would consume rye bread daily for food. A particular incident in which the rye bread started to go bad, and the population did not notice. People were buying and serving rye bread infected with the ergot fungus. On a particular night in mid 944 A.D. people in Paris were enjoying dinner and drinking lightly. Around two hours later, people were in the streets considered to be mad. Half of the population of Paris died over the course of a few days of absolute insanity. This incident is referred to as the Ergot epidemic; the term "Werewolf" derives from people who had ingested ergot infected bread.
+Ergotism is the earliest recorded example of ''mycotoxicosis'', or poisoning caused by toxic molds.<ref name="Bennett Bentley 1999 Story Ergot">{{cite journal |last1=Bennett |first1=J.W. |last2=Bentley |first2=Ronald |title=Pride and Prejudice: The Story of Ergot |journal=Perspectives in Biology and Medicine |volume=42 |issue=3 |pages=333–355 |doi=10.1353/pbm.1999.0026|year=1999}}</ref>
+Early references to ergotism date back as far as 600 BC, an Assyrian tablet referred to it as a 'noxious pustule in the ear of grain'.<ref name="Ergot:from witchcraft to biotechnology">{{cite journal |last1=Haarmann |first1=Thomas |last2=Rolke |first2=Yvonne |last3=Giesbert |first3=Sabine |last4=Tudzynski |first4=Paul |title=Ergot:from witchcraft to biotechnology |journal=Molecular Plant Pathology |date=2009 |volume=10 |issue=4 |pages=563–77 |doi=10.1111/J.1364-3703.2009.00548.X |pmid=19523108 |pmc=6640538}}</ref> In 350 BC, the Parsees described 'noxious grasses that cause pregnant women to drop the womb and die in childbed'.<ref name="Ergot:from witchcraft to biotechnology" />
+In ancient Syria, ergot was called 'Daughter of Blood'.<ref name="Wellcome" /> Radulf Glaber described an ailment he called 'hidden fire' or ''ignus ocultus'', in which a burning of the limb is followed by its separation from the body, often consuming the victim in one night.<ref name="Wellcome" /> In 1588, Johannes Thallius wrote that it is called 'Mother of Rye', or ''rockenmutter'', and is used to halt bleeding.<ref name="Wellcome" />
+Human poisoning due to the consumption of rye bread made from ergot-infected grain was common in Europe in the Middle Ages. The first mention of a plague of gangrenous ergotism in Europe comes from Germany in 857, following this France and Scandinavia experienced similar outbreaks;<ref name="De Costa">{{cite journal |last1=De Costa |first1=Caroline |title=StAnthony's fire and living ligatures: a short history of ergometrine |journal=The Lancet |date=May 18, 2002 |volume=359 |issue=9319 |pages=1768–1770 |doi=10.1016/S0140-6736(02)08658-0 |pmid=12049883}}</ref> England is noticeably absent from the historical regions affected by ergotism as their main source of food was wheat, which is resistant to ergot fungi.<ref name="Wellcome">{{cite book |last1=Wellcome |first1=Henry S. |last2=Solomon |first2=Henry |title=From Ergot to Ernutin |date=June 19, 1908 |publisher=Canadian Medical Association |location=Ottawa |isbn=978-1331946151 |pages=1–60}}</ref>
+In 944, a massive outbreak of ergotism caused 40,000 deaths in the regions of Aquitaine, Limousin, Perigord, and Angoumois in France.<ref name="Bennett Bentley 1999 Story Ergot" /> In Hesse in 1596, Wendelin Thelius was one of the first to attribute ergotism poisoning to grain.<ref name="De Costa" /> In 1778, S. Tessier, observing a huge epidemic in Sologne, France in which more than 8,000 people died, recommended drainage of fields, compulsory cleaning of grain, and the substitution of potatoes for affected grain.<ref name="De Costa" />
+==Chemistry==
+{{chemistryStub}}
+==Pharmacology==
+{{pharmacologyStub}}
+==External links==
+*[https://en.wikipedia.org/wiki/Ergot Ergot (Wikipedia)]
+==See also==
+*[[Lysergamides]]
+*[[LSA]]
+*[[LSD]]
-==Consumption==
+==References==
-Consumption of the ergot fungus right off of the rye stalk is an absolutely terrible idea. This will cause Ergotism and you will suffer the same fate as the many people in Paris. No one should consume this fungus, as it will most definitely kill you.
+<references />
-[[Category:Stub]]