Talk:2-FMA: Difference between revisions

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It's not that I don't believe it, but can anyone source the "emotionality suppression" effect for me? I find it a bit interesting that it would do that. And this can and ought to be subjective experience reports, since this is not something scientific literature will deal with, at least at this stage of scientific interest in 2-FMA. --[[User:Graatch|Graatch]] ([[User talk:Graatch|talk]]) 05:16, 14 August 2017 (CEST)

:Hello Graatch, thanks for weighing in. The "emotionality suppression" effect was included on grounds of the core pharmacology 2-FMA shares with amphetamine (and to a lesser extent, NDRIs like methylphenidate) as agents that promote synaptic concentrations of dopamine and norepinephrine. If you look up the effects reported for common ADHD stimulant medication like 'Adderall', 'Ritalin', 'Focalin', etc. you will see a number of people reporting this as a common effect.

:Hello {{ping|Graatch}}, thanks for weighing in. The "emotionality suppression" effect was included on grounds of the core pharmacology 2-FMA shares with amphetamine (and to a lesser extent, NDRIs like methylphenidate) as agents that promote synaptic concentrations of dopamine and norepinephrine. If you look up the effects reported for common ADHD stimulant medication like 'Adderall', 'Ritalin', 'Focalin', etc. you will see a number of people reporting this as a common effect.

:Interestingly, this seems to occur heterogeneously among the ADHD population, in which either amphetamine or MPH will cause this more or less depending on the person. The common factor between these reports is that while the initial stages of stimulant use correspond with increased mood and the enhancement of emotions (particularly positive ones that promote sociability), these reports appear to decrease among those who have been on the medication for an extended period and have presumably built tolerance to these aspects. A small sample of such can be found here: https://www.reddit.com/r/ADHD/comments/3wn9se/how_do_people_tolerate_the_emotional_blunting/ And more can be found if you browse various ADHD forums, or forums with threads on regular (if not necessarily abusive) stimulant use.

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: Hope this was helpful. Please let me know if you have any other questions. [[User:Clarity|Clarity]] ([[User talk:Clarity|talk]]) 09:13, 14 August 2017 (CEST)

== Citation needed rollback? ==

I was wondering why these 3 effects are special among the others and need a specific citation since none of the others need it. According to the previous point on the talk page, effects were able to be added based off of the drug's similarity to amphetamine, surely abnormal heartbeat, and increased heartrate and blood pressure are basic enough effects of stimulants that they don't have to be specifically cited? How would you even go about sourcing an index effect especially for research chemicals? There aren't trip reports attached to every any of the listed effects let alone all of them and even then it would just be anecdotal claims since it's not part of a study or something. [[User:Pharmreduction|Pharmreduction]] ([[User talk:Pharmreduction|talk]]) 20:57, 13 August 2017 (PST)

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 It's not that I don't believe it, but can anyone source the "emotionality suppression" effect for me? I find it a bit interesting that it would do that. And this can and ought to be subjective experience reports, since this is not something scientific literature will deal with, at least at this stage of scientific interest in 2-FMA. --[[User:Graatch|Graatch]] ([[User talk:Graatch|talk]]) 05:16, 14 August 2017 (CEST)
-:Hello Graatch, thanks for weighing in. The "emotionality suppression" effect was included on grounds of the core pharmacology 2-FMA shares with amphetamine (and to a lesser extent, NDRIs like methylphenidate) as agents that promote synaptic concentrations of dopamine and norepinephrine. If you look up the effects reported for common ADHD stimulant medication like 'Adderall', 'Ritalin', 'Focalin', etc. you will see a number of people reporting this as a common effect.
+:Hello {{ping|Graatch}}, thanks for weighing in. The "emotionality suppression" effect was included on grounds of the core pharmacology 2-FMA shares with amphetamine (and to a lesser extent, NDRIs like methylphenidate) as agents that promote synaptic concentrations of dopamine and norepinephrine. If you look up the effects reported for common ADHD stimulant medication like 'Adderall', 'Ritalin', 'Focalin', etc. you will see a number of people reporting this as a common effect.
 :Interestingly, this seems to occur heterogeneously among the ADHD population, in which either amphetamine or MPH will cause this more or less depending on the person. The common factor between these reports is that while the initial stages of stimulant use correspond with increased mood and the enhancement of emotions (particularly positive ones that promote sociability), these reports appear to decrease among those who have been on the medication for an extended period and have presumably built tolerance to these aspects. A small sample of such can be found here: https://www.reddit.com/r/ADHD/comments/3wn9se/how_do_people_tolerate_the_emotional_blunting/ And more can be found if you browse various ADHD forums, or forums with threads on regular (if not necessarily abusive) stimulant use.
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 : Hope this was helpful. Please let me know if you have any other questions. [[User:Clarity|Clarity]] ([[User talk:Clarity|talk]]) 09:13, 14 August 2017 (CEST)
+== Citation needed rollback? ==
+I was wondering why these 3 effects are special among the others and need a specific citation since none of the others need it. According to the previous point on the talk page, effects were able to be added based off of the drug's similarity to amphetamine, surely abnormal heartbeat, and increased heartrate and blood pressure are basic enough effects of stimulants that they don't have to be specifically cited? How would you even go about sourcing an index effect especially for research chemicals? There aren't trip reports attached to every any of the listed effects let alone all of them and even then it would just be anecdotal claims since it's not part of a study or something. [[User:Pharmreduction|Pharmreduction]] ([[User talk:Pharmreduction|talk]]) 20:57, 13 August 2017 (PST)