Template:DangerousInteractions/Psychedelics: Difference between revisions

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*'''[~~https~~:~~//en.wikipedia.org/wiki/~~Lithium_(medication) [[DangerousInteraction::Lithium]]]''' - Lithium is commonly prescribed in the treatment of [https://en.wikipedia.org/wiki/Bipolar_disorder bipolar disorder]. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of [[psychosis]] and [[seizures]]. As a result, this combination is strictly discouraged.

*'''[[Wikipedia:Lithium_(medication)|[[DangerousInteraction::Lithium]]]]''' - Lithium is commonly prescribed for the treatment of [https://en.wikipedia.org/wiki/Bipolar_disorder bipolar disorder]. There is a large body of anecdotal evidence that suggests taking it with [[psychedelics]] significantly increases the risk of [[psychosis]] and [[seizures]]. As a result, this combination is strictly discouraged.

*'''[[UncertainInteraction::Cannabis]]''' - Cannabis ~~has~~ an unexpectedly strong and unpredictable synergy with the effects of ~~psychedelics~~. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like [[anxiety]], [[paranoia]], [[panic attacks]], and [[psychosis]]. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid ~~over intake~~.

*'''[[[[UncertainInteraction::Cannabis]]]]''' - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of {{PAGENAME}}. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like [[anxiety]], [[paranoia]], [[panic attacks]], and [[psychosis]]. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.

*'''[[UncertainInteraction::Stimulants]]''' ~~('''''~~[[~~Amphetamine~~]], [[cocaine]], [[methylphenidate]]~~''''', ...) - Stimulants~~ affect many parts of the brain and alter dopaminergic function. ~~Combined with psychedelics, stimulation~~ can ~~turn into severe~~ [[anxiety]], [[~~Panic attacks|panic~~]], [[~~thought loops~~]], and [[~~paranoia~~]]. This interaction may result in an elevated risk of [[mania]] and [[psychosis]].{{citation needed}}

*'''[[[[UncertainInteraction::Stimulants]]]]''' - Stimulants like [[amphetamine]], [[cocaine]] or [[methylphenidate]] affect many parts of the brain and alter [[dopamine|dopaminergic]] function. This combination can increase the risk of [[anxiety]], [[paranoia]], [[panic attacks]], and [[thought loops]]. This interaction may also result in an elevated risk of [[mania]] and [[psychosis]].{{citation needed}}

*'''[[UnsafeInteraction::Tramadol]]''' - Tramadol ~~lowers~~ the seizure threshold<ref>{{cite journal|last1=Talaie|first1=H.|last2=Panahandeh|first2=R.|last3=Fayaznouri|first3=M. R.|last4=Asadi|first4=Z.|last5=Abdollahi|first5=M.|title=Dose-independent occurrence of seizure with tramadol|year=2009|journal=Journal of Medical Toxicology|volume=5|issue=2|pages=63-67|doi=10.1007/BF03161089|issn=1556-9039}}</ref> and [[psychedelics]] may act ~~as triggers for~~ seizures in susceptible individuals.{{citation needed}}

*'''[[[[UnsafeInteraction::Tramadol]]]]''' - Tramadol is well-documented to lower the seizure threshold<ref>{{cite journal|last1=Talaie|first1=H.|last2=Panahandeh|first2=R.|last3=Fayaznouri|first3=M. R.|last4=Asadi|first4=Z.|last5=Abdollahi|first5=M.|title=Dose-independent occurrence of seizure with tramadol|year=2009|journal=Journal of Medical Toxicology|volume=5|issue=2|pages=63-67|doi=10.1007/BF03161089|issn=1556-9039}}</ref> and [[psychedelics]] may act to trigger seizures in susceptible individuals.{{citation needed}}

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-*'''[https://en.wikipedia.org/wiki/Lithium_(medication) [[DangerousInteraction::Lithium]]]''' - Lithium is commonly prescribed in the treatment of [https://en.wikipedia.org/wiki/Bipolar_disorder bipolar disorder]. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of [[psychosis]] and [[seizures]]. As a result, this combination is strictly discouraged.
+*'''[[Wikipedia:Lithium_(medication)|[[DangerousInteraction::Lithium]]]]''' - Lithium is commonly prescribed for the treatment of [https://en.wikipedia.org/wiki/Bipolar_disorder bipolar disorder]. There is a large body of anecdotal evidence that suggests taking it with [[psychedelics]] significantly increases the risk of [[psychosis]] and [[seizures]]. As a result, this combination is strictly discouraged.
-*'''[[UncertainInteraction::Cannabis]]''' - Cannabis has an unexpectedly strong and unpredictable synergy with the effects of psychedelics. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like [[anxiety]], [[paranoia]], [[panic attacks]], and [[psychosis]]. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid over intake.
+*'''[[[[UncertainInteraction::Cannabis]]]]''' - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of {{PAGENAME}}. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like [[anxiety]], [[paranoia]], [[panic attacks]], and [[psychosis]]. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
-*'''[[UncertainInteraction::Stimulants]]''' ('''''[[Amphetamine]], [[cocaine]], [[methylphenidate]]''''', ...) - Stimulants affect many parts of the brain and alter dopaminergic function. Combined with psychedelics, stimulation can turn into severe [[anxiety]], [[Panic attacks|panic]], [[thought loops]], and [[paranoia]]. This interaction may result in an elevated risk of [[mania]] and [[psychosis]].{{citation needed}}
+*'''[[[[UncertainInteraction::Stimulants]]]]''' - Stimulants like [[amphetamine]], [[cocaine]] or [[methylphenidate]] affect many parts of the brain and alter [[dopamine|dopaminergic]] function. This combination can increase the risk of [[anxiety]], [[paranoia]], [[panic attacks]], and [[thought loops]]. This interaction may also result in an elevated risk of [[mania]] and [[psychosis]].{{citation needed}}
-*'''[[UnsafeInteraction::Tramadol]]''' - Tramadol lowers the seizure threshold<ref>{{cite journal|last1=Talaie|first1=H.|last2=Panahandeh|first2=R.|last3=Fayaznouri|first3=M. R.|last4=Asadi|first4=Z.|last5=Abdollahi|first5=M.|title=Dose-independent occurrence of seizure with tramadol|year=2009|journal=Journal of Medical Toxicology|volume=5|issue=2|pages=63-67|doi=10.1007/BF03161089|issn=1556-9039}}</ref> and [[psychedelics]] may act as triggers for seizures in susceptible individuals.{{citation needed}}
+*'''[[[[UnsafeInteraction::Tramadol]]]]''' - Tramadol is well-documented to lower the seizure threshold<ref>{{cite journal|last1=Talaie|first1=H.|last2=Panahandeh|first2=R.|last3=Fayaznouri|first3=M. R.|last4=Asadi|first4=Z.|last5=Abdollahi|first5=M.|title=Dose-independent occurrence of seizure with tramadol|year=2009|journal=Journal of Medical Toxicology|volume=5|issue=2|pages=63-67|doi=10.1007/BF03161089|issn=1556-9039}}</ref> and [[psychedelics]] may act to trigger seizures in susceptible individuals.{{citation needed}}