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Template:DangerousInteractions/Psychedelics: Difference between revisions

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*'''[[UncertainInteraction::Cannabis|[[Cannabis]]]]''' - Cannabis has an unexpectedly strong and somewhat unpredictable synergy with the effects of psychedelics. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like [[anxiety]], [[paranoia]], [[panic attacks]], and [[psychosis]]. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid over intake.
*'''[[Wikipedia:Lithium_(medication)|[[DangerousInteraction::Lithium]]]]''' - Lithium is commonly prescribed for the treatment of [https://en.wikipedia.org/wiki/Bipolar_disorder bipolar disorder]. There is a large body of anecdotal evidence that suggests taking it with [[psychedelics]] significantly increases the risk of [[psychosis]] and [[seizures]]. As a result, this combination is strictly discouraged.
*'''[https://en.wikipedia.org/wiki/Lithium_(medication) [[DangerousInteraction::Lithium]]]''' - Lithium is often prescribed as a treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
*'''[[[[UncertainInteraction::Cannabis]]]]''' - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of {{PAGENAME}}. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like [[anxiety]], [[paranoia]], [[panic attacks]], and [[psychosis]]. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
*'''[[UncertainInteraction::Stimulants|[[Stimulants]]]]''' (''[[amphetamines]], [[cathinones]], [[cocaine]], [[phenidates]]'', etc.) - Stimulants affect many parts of the brain and alter dopaminergic function. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]], and [[paranoia]]. This interaction may result in an elevated risk of [[mania]] and [[psychosis]].{{citation needed}}
*'''[[[[UncertainInteraction::Stimulants]]]]''' - Stimulants like [[amphetamine]], [[cocaine]] or [[methylphenidate]] affect many parts of the brain and alter [[dopamine|dopaminergic]] function. This combination can increase the risk of [[anxiety]], [[paranoia]], [[panic attacks]], and [[thought loops]]. This interaction may also result in an elevated risk of [[mania]] and [[psychosis]].{{citation needed}}
*'''[[UnsafeInteraction::Tramadol|[[Tramadol]]]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5(2), 63-67. https://doi.org/10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures in susceptible individuals.{{citation needed}}
*'''[[[[UnsafeInteraction::Tramadol]]]]''' - Tramadol is well-documented to lower the seizure threshold<ref>{{cite journal|last1=Talaie|first1=H.|last2=Panahandeh|first2=R.|last3=Fayaznouri|first3=M. R.|last4=Asadi|first4=Z.|last5=Abdollahi|first5=M.|title=Dose-independent occurrence of seizure with tramadol|year=2009|journal=Journal of Medical Toxicology|volume=5|issue=2|pages=63-67|doi=10.1007/BF03161089|issn=1556-9039}}</ref> and [[psychedelics]] may act to trigger seizures in susceptible individuals.{{citation needed}}
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