4-HO-DET

4-HO-DET
Chemical Nomenclature
Common names	DiPT
Substitutive name	N,N-Diisopropyltryptamine
Systematic name	3-[2-(Diisopropylamino)ethyl]indole
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Smoked Dosage Threshold 5 mg Light 10 - 15 mg Common 15 - 20 mg Strong 20 - 30 mg Heavy 30 mg + Duration Total 15 - 60 minutes Onset 5 - 15 minutes ⇣ Oral Dosage Threshold 15 mg Light 15 - 30 mg Common 30 - 75 mg Strong 75 - 150 mg Heavy 150 mg + Duration Total 3 - 26 hours Onset 30 - 60 minutes Offset 2 - 24 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

4-HO-DET also known as 4-hydroxy-diethyl-tryptamine, CZ-74, or ethocin is a hallucinogenic psychedelic drug of the tryptamine family.

This compound was first discovered in the late 1950s by Albert Hofmann and Franz Troxler. The substance was used together with its phosphoryloxy-analog 4-PO-DET in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.

Today it is used as a recreational or entheogenic compound through the use of online research chemical vendors. However, it remains relatively uncommon and has very little history of human usage.

Chemistry

This chemistry section is incomplete. You can help by adding to it.

DiPT is a derivative of tryptamine formed by substituting isopropyl groups for the two hydrogen atoms attached to the non-aromatic nitrogen atom in the tryptamine molecule.

Pharmacology

Main article: Serotonergic psychedelic

DiPT acts as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from DiPT's efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

General effects

Although DiPT's effects are primarily auditory, some users have reported that at higher doses they noticed a lack of coordination or balance, confusion, and some users have reported minor visual distortions. Aside from these, the most prevalent non-auditory effect is inner ear pressure (which has been painful in some instances, for example when combined with MDMA). Unlike other psychedelics, users' set and setting doesn't seem to influence what is experienced.

Auditory effects

There is much speculation as to the nature of DiPT's aural distortion. At lower dosages, it has been reported to have an effect similar to a flanging, or a phase shift. At medium and higher dosages, the effect of DiPT is typically a radical shift downward in perceived pitch. This shift tends to be nonlinear, in that the shift downwards varies in relation to the initial pitch. This can produce bizarre sounds and render music disharmonious.

There has been an experiment involving subjects with perfect pitch, the goal of which was to determine whether the pitch difference is truly distortive or linear, the results of which indicated that there is no clear relationship between perceived pitch and actual pitch. Although recent unpublished research has examined the role of DiPT in hearing perception in rodent, it is not clear that the auditory effect is preserved in nonhuman species; this research indicates that DiPT does not produce effects similar to other tryptamine psychedelics such as DPT and 5-MeO-DMT in acoustic startle reflex paradigms. DiPT still remains widely unexplored.

These auditory effects of DiPT are common in their occurrence and exhibit a full range of effects which commonly includes:

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

The toxicity and long-term health effects of recreational DiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DiPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychedelic community who have tried DiPT suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

Tolerance and addiction potential

DiPT is non-habit forming and the desire to use it can actually decrease with use. It is most often self-regulating.

An almost immediate tolerance is built to DiPT after ingestion, preventing one from experiencing its full effects more often than every 4-7 days unless they increase their dose significantly.

Legal issues

• United Kingdom - As is the case with many PiHKAL and TiHKAL drugs, it is Class A in the UK, making it illegal to possess or use.
• United States - DiPT is not scheduled at the federal level in the United States, but it could be considered an analog of 5-MeO-DiPT, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act. Some of the people arrested in Operation Web Tryp were selling DiPT.
• Florida - "DiPT (N,N-Diisopropyltryptamine)" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.

See also

• DiPT (erowid)
• DiPT (wikipedia)
• DiPT (TiHKAL)
• DiPT (tripsit)
• Tryptamine
• Psychedelic