List of bufotoxins

Revision as of 00:41, 12 May 2024 by >David Hedlund (==External links== * [https://en.wikipedia.org/wiki/Bufotoxin Bufotoxin (Wikipedia)])

Some bufo secretions are toxic

The toxic substances found in toads can be divided by chemical structure in two groups:

  1. bufadienolides, which are cardiac glycosides (e.g., bufotalin, bufogenin)
  2. tryptamine-related substances (e.g., bufotenin)
Ingestion of digoxin-like cardiac glycosides can be fatal. Ingestion of Bufo toad poison and eggs by humans has resulted in several reported cases of poisoning,[1][2][3] some of which resulted in death. A court case in Spain, involving a physician who dosed people with smoked Mexican Toad poison, one of his customers died after inhaling three doses, instead of the usual of only one, had images of intoxicated with this smoke suffering obvious hypocalcemic hand muscular spasms.[3][4][5]

Toads known to secrete bufotoxins include the following:[6]

  • Colorado River toad (Incilius alvarius)
  • Rhinella arenarum
  • Rhinella diptycha
  • Nannophryne variegata

References

  1. Hitt M, Ettinger DD (June 1986). "Toad toxicity". The New England Journal of Medicine. 314 (23): 1517–1518. doi:10.1056/NEJM198606053142320. PMID 3702971. 
  2. Ragonesi DL (1990). "The boy who was all hopped up". Contemporary Pediatrics. 7: 91–4. 
  3. 3.0 3.1 Brubacher JR, Ravikumar PR, Bania T, Heller MB, Hoffman RS (November 1996). "Treatment of toad toxin poisoning with digoxin-specific Fab fragments". Chest. 110 (5): 1282–1288. doi:10.1378/chest.110.5.1282. PMID 8915235. 
  4. Gowda RM, Cohen RA, Khan IA (April 2003). "Toad venom poisoning: resemblance to digoxin toxicity and therapeutic implications". Heart. 89 (4): 14e–14. doi:10.1136/heart.89.4.e14. PMC 1769273 . PMID 12639891. 
  5. Lever, Christopher (2001). The Cane Toad: The History and Ecology of a Successful Colonist. Westbury Academic & Scientific Publishing. ISBN 978-1-84103-006-7.