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Talk:Salbutamol
Revision as of 07:57, 12 March 2024 by >Lilylunatic(link & citation fixes)
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Salbutamol (also known as Albuterol, or by brand names including Ventolin) is a stimulant substance of the phenethylamine class, acting as a β₂ adrenergic receptor agonist. It is commonly used for the treatment of asthma and COPD(chronic obstructive pulmonary disease).
Salbutamol was discovered 1966, by a Team lead by David Jack, the first medication laucned was Ventolin. Until today Salbutamol remains one of the most effective rescue inhalers [citation needed].[1]
Salbutamol has a history to be used for doping due to its bronchodialating effects.[2]
Salbutamol is sold as a racemic mixture. The (R)-(−)-enantiomer (CIP nomenclature) is shown in the image at right (top), and is responsible for the pharmacologic activity; the (S)-(+)-enantiomer (bottom) blocks metabolic pathways associated with elimination of itself and of the pharmacologically active enantiomer (R)[3]
Salbutamol acts on β2-adrenergic receptors inducing muscle relaxation.[4]
Parmacokinetics
Inhaled Salbutamol affects bronchial muscles without entering the bloodstream. Trace amounts appear two to three hours after inhalation.
Within 24h approximately 70% of the administered dose is eliminated.[4]
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
↑Fitch, Ken D. (2017). "The enigma of inhaled salbutamol and sport: unresolved after 45 years". Drug Testing and Analysis. 9 (7): 977–982. doi:10.1002/dta.2184. ISSN1942-7603.
