Talk:Clozapine

Please revise the article immediately. Neither the link format follows our usual format, nor does a summary or detailed substancebox exist.

This article is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

Template:Proofread

Clozapine
Chemical Nomenclature
Common names	Clozaril, FazaClo
Substitutive name	Clozapine
Systematic name	8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Class Membership
Psychoactive class	Antipsychotic
Chemical class	Dibenzodiazepine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 6.125 mg Light 12.5 - 25 mg Common 37.5 - 50 mg Strong 50 - 100 mg Heavy 100 mg + Duration Total - hours Onset - minutes DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Summary sheet: Clozapine Clozapine (trade name Clozaril) is an antipsychotic medication that is used to treat severe schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics). Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or similar disorders (Delirium, bipolar disorder, extreme cases of anxiety). Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine. Chemistry A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Year introduced: 1991(1975) Physical effects Itchiness Constipation Shaking Drooling Increased perspiration Perception of increased weight Dehydration Blurred Vision Dizziness Seizure Headaches Cognitive effects Sleepiness Delusions Hallucinations Amnesia Agitation Confusion* Cognitive Fatigue Experience reports Anecdotal reports which describe the effects of this compound within our experience index include: Additional experience reports can be found here: https://erowid.org/experiences/subs/exp_Clozapine_.shtml Erowid Experience Vaults: Clozapine] Legal issues This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. United States: Clozapine is not a controlled substance, but is a prescription-only medicine. Bloodwork for a condition called agranulocytosis is often done for safety before prescribing. Australia: Clozapine is a schedule four substance, meaning it is a prescription-only medicine. See also Responsible use Antipsychotic Delusions Quetiapine Prochlorperazine External links (Drugs.com) (Wikipedia) References http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2002/19758se1-047ltr.pdf https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0009695/?report=details#side_effects https://www.ncbi.nlm.nih.gov/mesh/68003024