PsychonautWiki Archive

2C-B-FLY

Revision as of 03:53, 11 April 2017 by >MDMQualone

2C-B-FLY is a psychedelic phenethylamine of the 2C-x family which was first synthesized by Aaron P. Monte in 1996.[1][2] It produces psychedelic and mild entactogenic effects which typically last 6–8 hours, or up to 12 hours in larger doses. It presents effects which are similar to 2C-B, mescaline and 2C-D.

2C-B-FLY
Chemical Nomenclature
Common names 2C-B-FLY
Substitutive name 8-bromo-2,3,6,7-benzo-dihydro-difuran-ethylamine
Systematic name [[systematic name::2-(4-bromo-2,3,6,7-tetrahydrofuro[2,3-f][1]benzofuran-8-yl)ethanamine]]
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine / Benzodihydrodifuran
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 2 mg
Light 5 - 10 mg
Common 10 - 18 mg
Strong 18 - 25 mg
Heavy 25 mg +
Duration
Total 7 - 12 hours
Onset 30 - 60 minutes
Come up 1 - 2 hours
Peak 3 - 5 hours
Offset 2 - 3 hours
After effects 6 - 24 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: 2C-B-FLY

Very little is known about this substance, but it gained popularity around 2005 before becoming significantly less common after two deaths occurred in October 2009 after the ingestion of a substance that was mislabeled and sold as 2C-B-FLY but was actually Bromo-DragonFLY.[3]

It has recently become easily available again through online research chemical vendors where it is being sold as a designer drug.

Chemistry

2C-B-FLY is a substituted molecule of the phenethylamine and dihydrobenzofuran classes of drugs. 2C-B-FLY features a phenyl ring bound to an amino (NH2) group through an ethyl chain and contains a bromine atom attached to carbon R4 of the phenyl ring. 2C-B-FLY is an atypical psychedelic phenethylamine which is closely analogous to 2C-B; it is the dihydrofuran analog to 2C-B, where it incorporates the methoxy groups bound to R2 and R5 of 2C-B into five member dihydrofuran rings fused to the central benzene ring.

2C-B-FLY belongs to a group of phenethylamine derivatives referred to as the FLY compounds, named for their insect-like appearance of two “wing-like” tetrahydrofuran rings fused on the opposite sides of the central benzene ring. The incorporation of the two methoxy groups into the 5 member rings fixes them into the optimum position for binding to the receptors they interact with resulting in an increase in potency compared to the compound's non-rigid counterpart 2C-B.[4]

Pharmacology

Further information: Serotonergic psychedelic

2C-B-FLY's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. It also has a high binding affinity for the 5-HT1D, 5-HT1E, 5-HT1A, 5-HT2B and 5-HT2C receptors.[5]

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

In comparison to 2C-B, this compound presents a significantly more pronounced body high/load, stronger visual effects, more complex geometry and more in-depth hallucinations which are comparable to mescaline, 2C-E or other phenethylamine psychedelics at higher doses. Lower doses, however, are associated with more entactogenic as opposed to classically psychedelic effects.

Physical effects

The physical effects of 2C-B-FLY are comparable to that of traditional phenethylamines such as 2C-E, mescaline and 2C-T-7.

Many people have reported general gastrointestinal disturbances using compound which include diarrhoea, nausea, moderate to severe stomach bloating and general gassiness at moderate to heavy dosages. These effects are comparable to that of 5-MeO-MiPT, 2C-T-7 and other compounds with highly suspected MAO-altering properties, suggesting that 2C-B-FLY may potentially have such MAO-altering properties of its own, although this has yet to be confirmed.

Cognitive effects

It is worth noting that despite the potential cognitive effects of 2C-B-FLY, it tends to maintain a level of relatively normal and sober thought structure regardless of the subjective visual, physical and cognitive accompanying effects intensity. This leaves the user in control in a manner which would not be possible on many compounds such as 4-AcO-DMT, psilocin or LSD due to their accompanying confusion and delusions.

Visual effects

Enhancements

Distortions

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of mescaline, 2C-B and 2C-D than psilocin or ayahuasca. It can be comprehensively described through its style variations as intricate in complexity, abstract in form, synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, flat in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. They have a a contradictory combination of a very "natural" but also "neon digital" feel to them and at higher dosages are significantly more likely to result in states of level 8B visual geometry over level 8A.

Hallucinatory states

2C-B-FLY produces a full range of high level hallucinatory states in a fashion that is comparable to mescaline or 2C-E. This is more consistent and reproducible than that of many other commonly used psychedelics such as 2C-B or LSD. It tends to occur at heavier dosages and integrates seamlessly with the accompanying geometry. These effects generally include:

Auditory effects

After effects

The effects which occur during the offset of this compound are comparable to that of a mild stimulant or entactogen. The experience generally feels negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and may occur because of neurotransmitter depletion or receptor downregulation. Its effects commonly include:

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 2C-B-FLY do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-B-FLY is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 2C-B-FLY suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

2C-B-FLY is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-B-FLY are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-B-FLY presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 2C-B-FLY all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

If 2C-B-FLY does have suspected MAO-altering effects, this could indicate that 2C-B-FLY is more likely to induce serotonin syndrome or general monoamine overload (especially at high dosages) than other serotonergic psychedelics.[6] This may make it dangerous to combine it with MAOIs, stimulants and certain substances which modulate synaptic concentrations of neurotransmitters such as serotonin, dopamine and norepinephrine through unknown mechanisms. These substances include but are not limited to:

 

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United States - 2C-B-FLY is unscheduled and uncontrolled in the United States. However, it may fall under the scope of the Federal Analog Act if it is intended for human consumption given its similarity to 2C-B.
  • United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[7]
  • Canada: 2C-B-FLY would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[8]

See also

References

  1. ↑ https://erowid.org/chemicals/2cb_fly/2cb_fly_info1.shtml
  2. ↑ http://www.sciencedirect.com/topics/page/2C-B-FLY
  3. ↑ Information on Reported Deaths Related to 2C-B-FLY | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml
  4. ↑ http://heffter.org/docs/hrireview/01/chapter5.pdf
  5. ↑ Psychedelics and the human receptorome. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20126400
  6. ↑ Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
  7. ↑ Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
  8. ↑ Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
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