4-AcO-DET

4-AcO-DET
Chemical Nomenclature
Common names	4-AcO-DET, 4-Acetoxy-DET, Ethacetin
Substitutive name	4-Acetoxy-N,N-diethyltryptamine
Systematic name	3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 5 mg Light 10 - 15 mg Common 15 - 20 mg Strong 20 - 35 mg Heavy 35 mg + Duration Total 4 - 7 hours Onset 20 - 60 minutes Come up 1 - 1.5 hours Peak 1.5 - 3 hours Offset 1 - 2 hours After effects 2 - 4 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Summary sheet: 4-AcO-DET

4-AcO-DET (4-Acetoxy-N,N-diethyltryptamine; also known as Ethacetin) is an obscure synthetic psychedelic tryptamine. It is the acetylated form of 4-HO-DET (also known as Ethocin) and is a higher homolog of 4-AcO-DMT and 4-AcO-MET. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. 4-HO-DMT, 4-HO-MET and 4-HO-DET), in theory being inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.

There is very little information on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection. Today it is either used recreationally as a designer drug or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. It remains relatively rare and has very little documented history of human usage.

Chemistry

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R₄ of its indole heterocycle with an acetoxy (AcO) functional group CH₃COO−. It also contains isopropyl and methyl chains bound to the terminal amine R_N of its tryptamine backbone (DET).

4-AcO-DET is the N-substituted diethyl homolog of 4-HO-DMT (Psilocin). 4-AcO-DETis the acetate ester analog of DET and the N-substituted diethyl analog of 4-AcO-DMT.

Pharmacology

Main article: Serotonergic psychedelic

Like with most psychedelic tryptamines, 4-AcO-DET is thought to act principally as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from 4-AcO-DET's binding efficacy at the 5-HT_2A receptors.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• Appetite suppression
• Bodily pressures
• Excessive yawning
• Sedation and Stimulation - In terms of its effects on the physical energy levels of the tripper, 4-HO-DET is typically relaxing, stoning and mildly sedating, though it can also sometimes be very stimulating and "wired" feeling. This sense of sedation is often accompanied by uncontrollable yawning.
• Spontaneous tactile sensations - The "body high" of 4-AcO-DET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. Unlike other 4-substituted tryptamines, 4-AcO-DET is capable of being more stimulating and nerve/anxiety-inducing.
• Pupil dilation
• Runny nose
• Watery eyes

Uncomfortable physical side effects

• Abnormal heartbeat
• Dehydration
• Difficulty urinating or Frequent urination
• Dizziness
• Watery eyes
• Headaches
• Increased bodily temperature
• Muscle contractions
• Nausea
• Restless leg syndrome
• Stomach bloating
• Stomach cramps
• Teeth grinding

Cognitive effects

Much like its hydroxylated counterpart 4-HO-DET, the cognitive effects of 4-AcO-DET are described by many as being relatively complex and unpredictable in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a notable number of typical and unique psychedelic cognitive effects.

The most prominent of these typical effects generally include:

• Analysis enhancement
• Conceptual thinking
• Delusions
• Subconscious communication
• Déjà vu
• Emotion enhancement
• Enhancement and suppression cycles - This can be described as constant waves of extremely stimulated and profound thinking which are spontaneously surpassed in a cyclic fashion by waves of general thought suppression and mental intoxication. These two states seem to switch between each other in a consistent loop once every 20 - 60 minutes.
• Feelings of interdependent opposites
• Feelings of predeterminism
• Immersion enhancement
• Increased music appreciation
• Memory suppression
  • Ego death
• Novelty enhancement
• Personal bias suppression
• Thought connectivity
• Thought loops
• Time distortion
• Unity and interconnectedness
• Wakefulness

Visual effects

Enhancements

• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement

Distortions

• Drifting (melting, breathing, morphing and flowing)
• Colour shifting
• Depth perception distortions
• Perspective distortions
• Symmetrical texture repetition
• Tracers
• After images
• Brightness alteration
• Diffraction

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD, 2C-B or 2C-E than that of 4-AcO-DMT and ayahuasca. It can be comprehensively described through its variations as intricate in complexity, abstract in form, synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, non-immersive in depth and consistent in intensity. The visuals have a very "artificial" feel to them and at higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.

Hallucinatory states

4-AcO-DET and its various other forms can produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 4-AcO-DET

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-AcO-DET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-DET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-DET suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-AcO-DET is not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics it is most often thought to be self-regulating.

Tolerance to the effects of 4-AcO-DET are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-AcO-DET presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 4-AcO-DET all psychedelics will have a reduced effect.

Legal issues

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

Due to its relative obscurity, the possession and sale of 4-AcO-DET is unscheduled in most countries.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

See also

• Responsible use
• Research chemical
• Tryptamine
• 4-HO-DET
• 4-AcO-DMT
• 4-AcO-MET

External links

• 4-AcO-DET (Wikipedia)
• 4-AcO-DET (Erowid)
• 4-AcO-DET (TripSit)