List of polysubstance combinations

Poly drug use refers to the use of two or more psychoactive drugs in combination to achieve a particular effect. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.

A useful chart from [www.tripsit.me TripSit.me] which can be used to identify dangerous drug combinations quickly and easily.

Notable combinations

• Ayahuasca: MAOIs with DMT
• Pharmahuasca: MAOIs with DMT
• Sextasy: MDMA with sildenafil (Viagra)
• Speedball: Cocaine with heroin or morphine