Substituted phenidates

Substituted phenidates (also known as phenidates) are a class of chemicals that include compounds that predominantly produce traditional stimulant effects when administered. They may be defined as esters of ritalinic acid and its analogs.

Generic structure of a phenidate molecule.

Chemistry

Substituted phenidates are a chemical class based upon the molecule methylphenidate. The molecular structure of methylphenidate is comprised of a phenethylamine core with a carbon chain substitution at the R_α position that links to the R_N position, forming a piperidine ring. It also includes a substitution at the R_β position of methyl acetate.

Pharmacology

This pharmacology section is incomplete. You can help by adding to it.

Substituted phenidates primarily act as reuptake inhibitors of the monoamine neurotransmitters dopamine and norepinephrine, with the occasional addition of serotonin.

List of substituted phenidates

Compound	R3	R4	RO	Structure
Methylphenidate	H	H	CH3
Ethylphenidate	H	H	CH2CH3
Isopropylphenidate	H	H	CH(CH3)2
Propylphenidate	H	H	CH2CH2CH3
4-Methylmethylphenidate	H	CH3	CH3
3,4-CTMP	Cl	Cl	CH3
4F-MPH	H	F	CH3
4F-EPH	H	F	CH2CH3
Methylnaphthidate (HDMP-28)	CH=CH-	CH=CH-	CH3
Ethylnaphthidate (HDEP-28)	CH=CH-	CH=CH-	CH2CH3

See also

• Responsible use
• Psychedelics
• Phenethylamines
• Substituted amphetamine
• Entactogens
• Stimulants