Routes of administration

General

The method in which a drug has been ingested can greatly effect the potency, duration, and overall experience of a drug. Many substances are more effective when consumed using certain ROA's over others, and some drugs are completely inactive using certain routes of administration. Determining a route of administration is highly dependent on the substance consumed, desired duration of the substance,and personal comfort.

Oral

Arguably the most common route of adminstration for most classes of drugs, oral adminstration allows a substance to be absorbed through blood vessels contained in the stomach, where Enterochromaffin cells contain approximately 90% of the bodys serotonin. [1] Due to this, absorption of serotonin releasing drugs such as MDMA, BK-MDMA, and MDAI have been shown to have a higher overall effectivity when compared to insufflation.