Talk:Estradiol

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Summary sheet: Estradiol

Estradiol
Chemical Nomenclature
Common names	Estradiol, Oestradiol, E2
Substitutive name	Estra-1,3,5(10)-triene-3,17β-diol
Systematic name	[[systematic name::(1S,3aS,3bR,9bS,11aS)-11a-Methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthrene-1,7-diol]]
Class Membership
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Bioavailability 5% Light 1 - 2 mg Common 2 - 4 mg Strong 4 - 8 mg Heavy 12 mg + Duration DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Estradiol (also known as estrogen, oestradiol, E or E2) is an estrogen steroid hormone and the major female sex hormone.

History and culture

It is a basic, natural estrogen. Chemically, it is a steroid, a derivative of estrone.

Responsible for the development of the female reproductive organs, proliferation of the endometrium, regulates the sexual cycle and affects sexual behavior. During the follicular phase, it is produced mainly in the ovaries by growing Graaf follicles. In the corpus luteum phase, it is secreted in very small amounts by the corpus luteum. It is also produced in the adrenal cortex and during pregnancy in the placenta.

Chemistry

Esters

Compound	Halflife via IM	Structure
Estradiol Valerate	1.2–7.2 days
Estradiol Cypionate	8–10 days
Estradiol Enantate	5.6–7.5 days
Estradiol Undecylate	~1 month

Pharmacology

This pharmacology section is incomplete. You can help by adding to it.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Decreased libido
  • Orgasm depression commonly in transgender women and cis men.
  • Body odor alteration commonly in transgender women.

Cognitive effects

• • Empathy, affection, and sociability enhancement
  • Cognitive euphoria commonly in Women.
  • Cognitive dysphoria commonly in Men.

Transpersonal effects

• If applicable, a brief paragraph summary of the substance's transpersonal effects may be included here. You may select from a list of transpersonal effects to add below here.
  • Identity alteration

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

• Erowid Experience Vaults: Estradiol

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

• Responsible use
• Hormone

External links

• Estradiol (Wikipedia)