PsychonautWiki Archive

4-HO-MET

Revision as of 21:46, 28 June 2015 by >Oskykins (Text replacement - "The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects." to "The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.")

Template:Proofread 4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine, or metocin, methylcybin), is a lesser-known psychedelic drug. It is a structural− and functional analog of psilocin as well the 4-hydroxyl analog of MET. 4-HO-MET was first synthesized by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), the dosage is listed as 10-20 mɡ[1] However, this varies greatly as some report very heavy experiences with doses as low as 17 mg, yet others report light experiences with doses as high as 30 mg.[2]

4-HO-MET
Chemical Nomenclature
Common names 4-HO-MET, Metocin, Methylcybin, Colour
Substitutive name 4-Hydroxy-N-methyl-N-ethyltryptamine
Systematic name 3-{2-[Ethyl(methyl)amino]ethyl}-1H-indol-4-ol
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


⇣ Smoked
Dosage
Threshold 5 mg
Light 10 - 25 mg
Common 25 - 35 mg
Strong 35 - 60 mg
Heavy 60 mg +
Duration
Total 25 - 45 minutes
Onset 15 - 120 seconds
⇣ Oral
Dosage
Threshold 5 mg
Light 5 - 15 mg
Common 15 - 25 mg
Strong 25 - 45 mg
Heavy 45 mg +
Duration
Total 4 - 6 hours
Onset 15 - 40 minutes
Come up 30 - 60 minutes
Peak 2 - 3 hours
Offset 1 - 1.5 hours
After effects 2 - 12 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions

4-HO-MET produces psilocin-like distortion of color, sound, and form. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. There have been no reports of deaths from 4-HO-MET, even though people have reported taking doses up to 150 mg,[3] more than an order of magnitude above the effective dose.[4]

It is worth noting that this compound has identical subjective effects to 4-AcO-MET. Although human studies concerning the metabolic fate of this drug are lacking, this similarity is hypothesized to be a result of 4-AcO-MET quickly being hydrolyzed into the free phenolic 4-HO-MET. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.

Chemistry

 
General formula of a tryptamine molecule.

4-HO-MET or 4-hydroxy-N-methyl-N-ethyltryptamine is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-MET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET). 4-HO-MET is a 4-hydroxy analogue of 4-AcO-MET and the N-substituted ethyl homologue of 4-HO-DMT. [5]

Pharmacology

Main article: Serotonergic psychedelic

4-AcO-MET's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The physical effects of 4-HO-MET can be broken down into several components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The "body high" of 4-HO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Sedation - In terms of its effects on the physical energy levels of the tripper, 4-HO-MET is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by compulsive yawning.
  • Nausea
  • Pupil dilation
  • Wakefulness

Cognitive effects

The cognitive effects of 4-HO-MET are described by many as somewhat relaxing, yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects.

The most prominent of these typical effects generally include:

Visual effects

A noteworthy aspect regarding this compound is that at sub-psychedelic doses, it appears to still produce visual effects, without any accompanying cognitive effects or "head space".

Enhancements

4-HO-MET presents a full and complete array of possible visual enhancements which generally includes:

Distortions

As for visual distortions and alterations, the effects experienced are detailed below:

Geometry

The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of Psilocin (4-HO-DMT) and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-HO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory "natural" and "synthetic" feel to them which is reminiscent of both LSD and and Psilocybin. Higher dosages are significantly more likely to result in states of Level 8A visual geometry over Level 8B.

Hallucinatory states

4-HO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Auditory effects

The auditory effects of 4-HO-MET are common in their occurrence and exhibit a full range of effects which commonly include:

Toxicity and harm potential

Lethal dosage

The toxicity and long term health effects of recreational 4-HO-MET use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4-HO-MET is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4-HO-MET within the psychonaut community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is no current data for the LD50 of 4-HO-MET, but it is thought to be high.

Tolerance and addiction potential

4-HO-MET does not seem to be physically addictive and many users experience a self-regulating quality. There seems to be a tolerance build up when used consecutively multiple days in a row which requires one to double their dosage each time to achieve the same effects.

  • Sveriges riksdag added 4-HO-MET to schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation LVFS 2012:6 listed as 4-HO-MET 3-[2-[etyl(metyl)amino]etyl]-1H-indol-4-ol[6]
  • 4-HO-MET is a class A drug in the UK, as a result of the tryptamine catch-all clause.

See also

References

  1. ↑ https://www.erowid.org/library/books_online/tihkal/tihkal21.shtm
  2. ↑ https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml
  3. ↑ Cosmic Mind Orgy | https://www.erowid.org/experiences/exp.php?ID=71218
  4. ↑ http://www.erowid.org/experiences/exp.cgi?S1=436&S2=-1&C1=-1&Str=
  5. ↑ http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=21
  6. ↑ https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf


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