Dangerous combinations

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Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Drug related deaths most commonly occur when combining depressants. Depressants affect parts of the brain that are responsible for respiration, and an overdose or combination of these drugs can result in fatal levels of respiratory depression. Death may also occur when a victim falls into deep enough unconsciousness to suffocate from their own vomit. Lying in the recovery position can prevent one from inhaling their own vomit.

Lying in the recovery position can prevent one from inhaling their own vomit.

Another possibly fatal combination of drugs are serotonergic substances, which might cause serotonin syndrome. This can also be caused alone by an overdose of said substances. Serotonin syndrome is a result of excess serotonin in the brain, which can cause seizures, anxiety, tremors, nausea, coma and possibly a deadly fever. Usually this is caused when a user has used an anti-depressant within the last 2 weeks of consuming said drug. These kind of antidepressants include monoamine oxidase inhibitors (MAOIs), serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRI).

Depressants

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Serotonergic drugs

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Other

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Health	Comedowns • Anxiety and panic attacks • Serotonin syndrome • Dehydration • Seizures • Overheating • Health consequences of drug use • Prenatal drug exposure • Sedation risks (Respiratory depression • Sedation injuries • Aspiration of vomit) • Stimulant psychosis • Hallucinogen persisting perception disorder

Dosage	Dosage classification • Choosing dosages • Dosage measurement (Eyeballing, Milligram scales) • Volumetric liquid dosing • Allergy testing • Routes of administration • Drug overdose • Compulsive redosing • Dosage form

Harm reduction	Reagent testing kits • Dangerous combinations • Festival and rave safety • International Day of Drug Checking • Safer injection guide • Sharing injection materials • Cotton fever • Recovery position • Naloxone • Mushroom hunting • Substance adulteration • Substance legality • Behavioral toxicity

Hallucinogens	Responsible use § hallucinogens • Set and setting (Setting • Mindset • Physical state) • Trip sitters • Anchors • Bad trips • Aborting trips

Specific drugs	Research chemicals • Synthetic cannabinoids • Cannabis • Stimulants • Benzodiazepines • Thienodiazepines • Opioids • Alcohol • Barbiturates • GHB, GBL, & 1,4-Butanediol • Hallucinogens • Deliriants • Dissociatives • Psychedelics

Addiction	Addiction • Addiction treatment • Tapering • Cold turkey • Drug withdrawal • Delirium tremens • Kindling • Post-acute-withdrawal syndrome (PAWS) • Physical dependence • Psychological dependence • Tolerance • Drug rehabilitation • Cravings • Anti-craving drugs • Drug replacement therapy • Relapse • Smoking cessation

Resources	Laboratory testing, botanical testing, purity testing kits, reagent testing kits • Safe injection sites (also known as drug consumption facilities) • Needle distribution programs • Naloxone programs • Methadone clinics • Crack pipe kits

Dangerous combinations

Contents

Depressants

Serotonergic drugs

Other

See also