PsychonautWiki Archive

4-HO-DET

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N,N-Diethyl-4-hydroxytryptamine (abbreviated 4-HO-DET; also known as 4-hydroxy-N,N-diethyltryptamine, CZ-74, or Ethocin) is a synthetic psychedelic tryptamine that is a close structural and functional analog of psilocin (4-HO-DMT), the principal psychoactive substance in magic mushrooms. It is notable for sharing many but of its core features while retaining variations in style and effects.

4-HO-DET
Chemical Nomenclature
Common names 4-HO-DET, Ethocin, CZ-74
Substitutive name N,N-Diethyl-4-hydroxytryptamine
Systematic name 3-(2-diethylaminoethyl)-1H-indol-4-ol
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 5 mg
Light 10 - 15 mg
Common 20 - 30 mg
Strong 30 - 45 mg
Heavy 45 mg +
Duration
Total 5 - 7 hours
Onset 20 - 45 minutes
Come up 30 - 60 minutes
Peak 2.5 - 3.5 hours
Offset 1.5 - 2 hours
After effects 1 - 4 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Summary sheet: 4-HO-DET

This compound was first discovered in the late 1950s by Albert Hofmann (famed inventor/discoverer of LSD) and Franz Troxler.[1][2] The substance was used together with its phosphoryloxy-analog 4-PO-DET in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.

As a psychedelic, 4-HO-DET remains relatively uncommon and has very little documentation of human usage. Today it is either used as a recreational substance or an entheogen. It is almost never available on the street and primarily acquired through the use of online research chemical vendors.

Chemistry

4-HO-DET, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-DET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET).

4-HO-DET is a 4-hydroxy analogue of 4-AcO-DET and the N-substituted diethyl homolog of 4-HO-DMT.

Pharmacology

Further information: Serotonergic psychedelic

4-HO-DET acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-HO-DET's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

 
 This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

In comparison to other tryptamines such as 4-AcO-DMT and 4-HO-DMT it is extremely similar in terms of its visual, cognitive and physical effects although it feels somewhat less natural and slightly more synthetic.

Physical effects

Cognitive effects

The cognitive effects of 4-HO-DET can be described as relaxing and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating.

The most prominent of these typical effects generally include:

Visual effects

Enhancements

Distortions

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, mostly synthetic in style, unstructured in organization, brightly lit and multicolored in scheme, glossy in shading, sharp in edges, large in size, slow in speed, smooth in motion, equally rounded and angular in corners, non-immersive in depth and consistent in intensity. They have a very "natural" feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory states

Auditory effects

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

 Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-HO-DET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DET suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-HO-DET is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 4-HO-DET are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-DET presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 4-HO-DET all psychedelics will have a reduced effect.

 

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[3]
  • United States - 4-HO-DET is unscheduled in the United States. It may be considered an analog of psilocin (4-HO-DMT) which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analog Act.
  • Sweden - 4-HO-DET is classified as a health hazard under the Act on the Prohibition of Certain Goods Dangerous to Health as of November 1, 2005 in the regulation SFS 2005:733, making it illegal to sell or possess.[4]

See also

References

  1. ↑ Therapeutic indoles for psychic stimulation and relief of mental depression | http://www.google.com/patents/US3072530
  2. ↑ United States Patent Office | https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf
  3. ↑ Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
  4. ↑ Svensk författningssamling | http://www.notisum.se/rnp/sls/sfs/20050733.pdf
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