Efavirenz: Difference between revisions

Line 73:

Efavirenz has a [[Toxicity::low toxicity]] relative to dose. Like many HIV medications, efavirenz [[Toxicity::may cause liver toxicity at high doses or after chronic use]].

It is strongly recommended that one use [[responsible ~~substance~~ use|harm reduction practices]] when using this drug.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.

===Tolerance and addiction potential===

Efavirenz is [[Addiction potential::not known to be habit-forming]]. While developing a tolerance to efavirenz is extremely rare, abusing efavirenz may cause HIV to become resistant to the ~~substance~~ and increase the viral load in patients with HIV.

Efavirenz is [[Addiction potential::not known to be habit-forming]]. While developing a tolerance to efavirenz is extremely rare, abusing efavirenz may cause HIV to become resistant to the drug and increase the viral load in patients with HIV.

===Dangerous interactions===

As efavirenz may cause hepatoxicity at high doses or after chronic use, it is not recommended to take this substance concurrently with other substances that may cause hepatoxicity. Efavirenz is an inducer of the CYP2B6 and CYP3A4 enzymes of the cytochrome P450 system, and as a result may change the metabolism of ~~substances~~ metabolized by them. Consuming garlic may decrease serum levels of efavirenz.

As efavirenz may cause hepatoxicity at high doses or after chronic use, it is not recommended to take this substance concurrently with other substances that may cause hepatoxicity. Efavirenz is an inducer of the CYP2B6 and CYP3A4 enzymes of the cytochrome P450 system, and as a result may change the metabolism of drugs metabolized by them. Consuming garlic may decrease serum levels of efavirenz.

====[[Serotonin syndrome]] risk====

@@ Line 73: / Line 73: @@
 Efavirenz has a [[Toxicity::low toxicity]] relative to dose. Like many HIV medications, efavirenz [[Toxicity::may cause liver toxicity at high doses or after chronic use]].
-It is strongly recommended that one use [[responsible substance use|harm reduction practices]] when using this drug.
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
 ===Tolerance and addiction potential===
-Efavirenz is [[Addiction potential::not known to be habit-forming]]. While developing a tolerance to efavirenz is extremely rare, abusing efavirenz may cause HIV to become resistant to the substance and increase the viral load in patients with HIV.
+Efavirenz is [[Addiction potential::not known to be habit-forming]]. While developing a tolerance to efavirenz is extremely rare, abusing efavirenz may cause HIV to become resistant to the drug and increase the viral load in patients with HIV.
 ===Dangerous interactions===
-As efavirenz may cause hepatoxicity at high doses or after chronic use, it is not recommended to take this substance concurrently with other substances that may cause hepatoxicity. Efavirenz is an inducer of the CYP2B6 and CYP3A4 enzymes of the cytochrome P450 system, and as a result may change the metabolism of substances metabolized by them.  Consuming garlic may decrease serum levels of efavirenz.
+As efavirenz may cause hepatoxicity at high doses or after chronic use, it is not recommended to take this substance concurrently with other substances that may cause hepatoxicity. Efavirenz is an inducer of the CYP2B6 and CYP3A4 enzymes of the cytochrome P450 system, and as a result may change the metabolism of drugs metabolized by them.  Consuming garlic may decrease serum levels of efavirenz.
 ====[[Serotonin syndrome]] risk====