Reuptake inhibitor: Difference between revisions

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'''Reuptake''' is a required aspect of neurological activity which regulates the amount of neurotransmitter present in a synapse after the transmission of a neural signal. Neurotransmission occurs by transporting information across neurons by an electrical impulse called an action potential. When an action potential reaches the synapse between two neurons, the pre-synaptic neuron releases neurotransmitters to transport the chemical signal across the synapse by binding to receptors on the post-synaptic neuron. Reuptake is achieved by transporter proteins which reabsorb the extracellular neurotransmitter back into the pre-synaptic neurone for reuse. Reuptake can determine the extent, duration, and spatial domain of receptor activation.

A '''reuptake inhibitor''', also known as a transporter blocker, is a drug that inhibits the reuptake of a [[neurotransmitter]] from the synapse into the presynaptic neurone, leading to an increase in the extracellular concentrations of the neurotransmitter ~~and therefore an increase~~ in ~~neurotransmission.~~ Various drugs utilize reuptake inhibition to exert their psychological and physiological effects, including many [[antidepressants]] and [[stimulants]].

A '''reuptake inhibitor''', also known as a transporter blocker, is a drug that inhibits the reuptake of a [[neurotransmitter]] from the synapse into the presynaptic neurone, leading to an increase in the extracellular concentrations of the neurotransmitter. The increased synaptic concentration of a neurotransmitter results in Various drugs utilize reuptake inhibition to exert their psychological and physiological effects, including many [[antidepressants]] and [[stimulants]].

Most known reuptake inhibitors affect the monoamine neurotransmitters [[serotonin]], [[noradrenaline]] (and [[adrenaline]]), and [[dopamine]]. However, there are also a number of pharmaceuticals and [[research chemicals]] that act as reuptake inhibitors for other neurotransmitters such as [[glutamate]], [[GABA]], glycine, adenosine, choline (the precursor of [[acetylcholine]]), and the endocannabinoids.

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-'''Reuptake''' is a required aspect of neurological activity which regulates the amount of neurotransmitter present in a synapse after the transmission of a neural signal. Neurotransmission occurs by transporting information across neurons by an electrical impulse called an action potential. When an action potential reaches the synapse between two neurons, the pre-synaptic neuron releases neurotransmitters to transport the chemical signal across the synapse by binding to receptors on the post-synaptic neuron.  Reuptake is achieved by transporter proteins which reabsorb the extracellular neurotransmitter back into the pre-synaptic neurone for reuse. Reuptake can determine the extent, duration, and spatial domain of receptor activation.
+'''Reuptake''' is a required aspect of neurological activity which regulates the amount of neurotransmitter present in a synapse after the transmission of a neural signal. Neurotransmission occurs by transporting information across neurons by an electrical impulse called an action potential. When an action potential reaches the synapse between two neurons, the pre-synaptic neuron releases neurotransmitters to transport the chemical signal across the synapse by binding to receptors on the post-synaptic neuron. Reuptake is achieved by transporter proteins which reabsorb the extracellular neurotransmitter back into the pre-synaptic neurone for reuse. Reuptake can determine the extent, duration, and spatial domain of receptor activation.
-A '''reuptake inhibitor''', also known as a transporter blocker, is a drug that inhibits the reuptake of a [[neurotransmitter]] from the synapse into the presynaptic neurone, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an increase in neurotransmission. Various drugs utilize reuptake inhibition to exert their psychological and physiological effects, including many [[antidepressants]] and [[stimulants]].
+A '''reuptake inhibitor''', also known as a transporter blocker, is a drug that inhibits the reuptake of a [[neurotransmitter]] from the synapse into the presynaptic neurone, leading to an increase in the extracellular concentrations of the neurotransmitter. The increased synaptic concentration of a neurotransmitter results in  Various drugs utilize reuptake inhibition to exert their psychological and physiological effects, including many [[antidepressants]] and [[stimulants]].
 Most known reuptake inhibitors affect the monoamine neurotransmitters [[serotonin]], [[noradrenaline]] (and [[adrenaline]]), and [[dopamine]]. However, there are also a number of pharmaceuticals and [[research chemicals]] that act as reuptake inhibitors for other neurotransmitters such as [[glutamate]], [[GABA]], glycine, adenosine, choline (the precursor of [[acetylcholine]]), and the endocannabinoids.