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Reuptake inhibitor: Difference between revisions
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==Types of reuptake inhibitors== | ==Types of reuptake inhibitors== | ||
*A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]] with negligible or no effects on the reuptake of other neurotransmitters. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or [[SSRIs]]. SSRIs bind to serotonin transporters (SERTs) to inhibit the reuptake of serotonin, increasing extracellular concentrations of the neurotransmitter. | *A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]] with negligible or no effects on the reuptake of other neurotransmitters. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or [[SSRIs]]. SSRIs bind to serotonin transporters (SERTs) to inhibit the reuptake of serotonin, increasing extracellular concentrations of the neurotransmitter. | ||
*A '''non-selective reuptake inhibitor''' will inhibit the reuptake of more than one type of [[neurotransmitter]]. An example of this is [[cocaine]], which acts as a serotonin-noradrenaline-dopamine reuptake inhibitor, or [[SNDRI]]. Ketamine is an example of a weak SNDRI, it is non-selective because it affects the reuptake of multiple neurotransmitters.<ref>Kohrs, R; Durieux, ME (November 1998). "Ketamine: Teaching an old drug new tricks". Anesthesia & Analgesia</ref> | *A '''non-selective reuptake inhibitor''' will inhibit the reuptake of more than one type of [[neurotransmitter]]. An example of this is [[cocaine]], which acts as a serotonin-noradrenaline-dopamine reuptake inhibitor, or [[SNDRI]]. Ketamine is an example of a weak SNDRI, it is non-selective because it affects the reuptake of multiple neurotransmitters.<ref>Kohrs, R; Durieux, ME (November 1998). "Ketamine: Teaching an old drug new tricks". Anesthesia & Analgesia | https://www.ncbi.nlm.nih.gov/pubmed/9806706</ref> | ||
==See also== | ==See also== | ||