This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Reuptake inhibitor: Difference between revisions
>Oskykins No edit summary |
>Kaylee m Text replacement - " drug " to " substance " |
||
| Line 1: | Line 1: | ||
[[File:Reuptake inhibitor.png|350px|thumb|right|The effect of reuptake inhibitors on the presynaptic neurone]]A '''reuptake inhibitor''', also known as a '''transporter blocker''', is a | [[File:Reuptake inhibitor.png|350px|thumb|right|The effect of reuptake inhibitors on the presynaptic neurone]]A '''reuptake inhibitor''', also known as a '''transporter blocker''', is a substance that inhibits the reuptake of a [[neurotransmitter]] from the synapse into the presynaptic neurone, leading to an increase in the extracellular concentrations of the neurotransmitter. Various drugs utilize reuptake inhibition to exert their psychological and physiological effects, including many [[antidepressants]] and [[stimulants]]. | ||
Reuptake is a required aspect of neurological activity which regulates the amount of neurotransmitters present in a synapse after the transmission of a neural signal. Neurotransmission occurs by transporting information across neurons by an electrical impulse called an action potential. When an action potential reaches the synapse between two neurons, the pre-synaptic neuron releases neurotransmitters to transport the chemical signal across the synapse by binding to receptors on the post-synaptic neuron. Reuptake is achieved by transporter proteins which reabsorb the extracellular neurotransmitter back into the pre-synaptic neurone for reuse. Reuptake can determine the extent, duration, and spatial domain of receptor activation. | Reuptake is a required aspect of neurological activity which regulates the amount of neurotransmitters present in a synapse after the transmission of a neural signal. Neurotransmission occurs by transporting information across neurons by an electrical impulse called an action potential. When an action potential reaches the synapse between two neurons, the pre-synaptic neuron releases neurotransmitters to transport the chemical signal across the synapse by binding to receptors on the post-synaptic neuron. Reuptake is achieved by transporter proteins which reabsorb the extracellular neurotransmitter back into the pre-synaptic neurone for reuse. Reuptake can determine the extent, duration, and spatial domain of receptor activation. | ||
| Line 12: | Line 12: | ||
==Types of reuptake inhibitors== | ==Types of reuptake inhibitors== | ||
*A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]] with negligible or no effects on the reuptake of other neurotransmitters. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or [[SSRIs]]. SSRIs solely target serotonin transporters (SERTs), blocking the reuptake of serotonin and increasing extracellular concentrations of the neurotransmitter.<ref>Selective Serotonin Reuptake Inhibitors (SSRI) Pathway (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896866/</ref> | *A '''selective reuptake inhibitor''' will inhibit the reuptake of a specific [[neurotransmitter]] with negligible or no effects on the reuptake of other neurotransmitters. An example of this is the class of antidepressants known as selective serotonin reuptake inhibitors, or [[SSRIs]]. SSRIs solely target serotonin transporters (SERTs), blocking the reuptake of serotonin and increasing extracellular concentrations of the neurotransmitter.<ref>Selective Serotonin Reuptake Inhibitors (SSRI) Pathway (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896866/</ref> | ||
*A '''non-selective reuptake inhibitor''' will inhibit the reuptake of more than one type of [[neurotransmitter]]. An example of this is [[cocaine]], which acts as a serotonin-noradrenaline-dopamine reuptake inhibitor, or [[SNDRI]]. Ketamine is an example of a weak SNDRI; it is non-selective because it affects the reuptake of multiple neurotransmitters.<ref>Kohrs, R; Durieux, ME (November 1998). "Ketamine: Teaching an old | *A '''non-selective reuptake inhibitor''' will inhibit the reuptake of more than one type of [[neurotransmitter]]. An example of this is [[cocaine]], which acts as a serotonin-noradrenaline-dopamine reuptake inhibitor, or [[SNDRI]]. Ketamine is an example of a weak SNDRI; it is non-selective because it affects the reuptake of multiple neurotransmitters.<ref>Kohrs, R; Durieux, ME (November 1998). "Ketamine: Teaching an old substance new tricks". Anesthesia & Analgesia (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/9806706</ref> | ||
==See also== | ==See also== | ||