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Research chemicals: Difference between revisions
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'''Research chemicals''' (also called '''experimental chemicals''' or '''unresearched chemicals''') are psychoactive substances which have undergone little to no human or animal medical research or investigation.<ref name="faq">Research Chemical FAQ - Experimental and Research Chemicals used as Psychoactives by Erowid & Murple v 1.6 - Jun 4, 2010 (Erowid) | https://www.erowid.org/psychoactives/research_chems/research_chems_faq.shtml</ref> The use of research chemicals may be more risky than the use of more well-studied drugs such as [[MDMA]], or [[cannabis]] because of the lack of studies. Most information about research chemicals is based on first-hand experiences and anecdotal evidence. More than one hundred research chemicals, including [[2C-E]] and [[DOM]], were discovered by Alexander Shulgin and written about in his books [[PiHKAL]] and [[TiHKAL]]. | '''Research chemicals''' (also called '''experimental chemicals''' or '''unresearched chemicals''') are psychoactive substances which have undergone little to no human or animal medical research or investigation.<ref name="faq">Research Chemical FAQ - Experimental and Research Chemicals used as Psychoactives by Erowid & Murple v 1.6 - Jun 4, 2010 (Erowid) | https://www.erowid.org/psychoactives/research_chems/research_chems_faq.shtml</ref> The use of research chemicals may be more risky than the use of more well-studied drugs such as [[MDMA]], or [[cannabis]] because of the lack of studies. Most information about research chemicals is based on first-hand experiences and anecdotal evidence. More than one hundred research chemicals, including [[2C-E]] and [[DOM]], were discovered by Alexander Shulgin and written about in his books [[PiHKAL]] and [[TiHKAL]]. | ||
Research chemicals have similar effects to many illegal drugs and are often invented in order to bypass current drug laws or improve upon existing substances. For example, [[MXE]] was invented to be "a stress-free version of ketamine" and the "perfect dissociative."<ref>Interview with a Ketamine Chemist By Hamilton Morris (Vice) | https://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2</ref> | Research chemicals have similar effects and molecular structures to many illegal drugs and are often invented in order to bypass current drug laws or improve upon existing substances. For example, [[MXE]] was invented to be "a stress-free version of ketamine" and the "perfect dissociative."<ref>Interview with a Ketamine Chemist By Hamilton Morris (Vice) | https://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2</ref> | ||
===Harm potential and toxicity=== | ===Harm potential and toxicity=== | ||
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In terms of risk factors, Erowid states that "mislabeling, misidentification, issues of purity, adulteration, and misrepresentation (substitution) are unfortunately a common problem with research chemicals."<ref name="erowid">Experimental & Research Chemicals (Synthetic Drugs, Novel Psychoactive Substances, New Psychoactive Substances, NPS, Replacement Psychoactives) (Erowid) | https://www.erowid.org/psychoactives/research_chems/</ref> It is recommended that one avoid branded products or blends if the active psychoactive compounds are not listed on the labelling.<ref name="tripsit">Research Chemicals (Tripsit) | https://wiki.tripsit.me/wiki/Research_Chemicals</ref> Combining research chemicals also presents an unknown risk due to the lack of research. | In terms of risk factors, Erowid states that "mislabeling, misidentification, issues of purity, adulteration, and misrepresentation (substitution) are unfortunately a common problem with research chemicals."<ref name="erowid">Experimental & Research Chemicals (Synthetic Drugs, Novel Psychoactive Substances, New Psychoactive Substances, NPS, Replacement Psychoactives) (Erowid) | https://www.erowid.org/psychoactives/research_chems/</ref> It is recommended that one avoid branded products or blends if the active psychoactive compounds are not listed on the labelling.<ref name="tripsit">Research Chemicals (Tripsit) | https://wiki.tripsit.me/wiki/Research_Chemicals</ref> Combining research chemicals also presents an unknown risk due to the lack of research. | ||
Caution should be used when dosing because not much is known about the dose range and lethal | Caution should be used when dosing because not much is known about the dose range and lethal doses. Research chemicals which have caused death at high doses include [[25I-NBOMe]]<ref name="one">25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml</ref>, [[25B-NBOMe]]<ref name="three">Other or Unknown NBOMe Compound Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/nbome/nbome_death.shtml</ref>, [[25C-NBOMe]]<ref name="two">25C-NBOMe (2C-C-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2cc_nbome/2cc_nbome_death.shtml</ref>, [[AMT]]<ref name="amt">AMT (Alphamethyltryptamine, IT-290) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/amt/amt_death.shtml</ref><ref name="amt2">Boland DM, Andollo W, Hime GW, Hearn WL. “Fatality due to acute alpha-methyltryptamine intoxication”. J Anal Toxicol. 2005 Jul-Aug;29(5):394-7. | https://www.erowid.org/references/refs_view.php?ID=6603</ref>, | ||
Dosing | Dosing | ||