Gabapentinoids: Difference between revisions

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[[File:Gabapentinoidsstructure.png|thumbnail|Diagram showing the structural similarities of [[~~pregabalin~~]], [[~~gabapentin~~]] and [[~~GABA |gamma-aminobutyric acid~~]].]]

[[File:Gabapentinoidsstructure.png|250px|thumbnail|Diagram showing the structural similarities of [[GABA|gamma-aminobutyric acid]] (GABA), [[pregabalin]] and [[gabapentin]].]]

'''Gabapentinoids''' are a class of chemical compounds that are derivatives of [[GABA |gamma-aminobutyric acid]] which block α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels |channels]]. While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.

'''Gabapentinoids''' are a class of chemical compounds that are derivatives of [[GABA|gamma-aminobutyric acid]] which block α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels|channels]]. While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.

Gabapentinoids are commonly used for epilepsy, neuropathic pain, and [[restless legs syndrome]]. Gabapentinoids are often [[Sedation |sedating]], have [[Seizure suppression |anticonvulsant]] effects, and [[Anxiety suppression |suppress anxiety]]. Drugs in this class include [[gabapentin]], [[F-phenibut]], [[phenibut]] and, [[pregabalin]]. Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[benzodiazepine ~~|benzodiazepines~~]], [[alcohol]] and [[opioid ~~|opioids~~]].

Gabapentinoids are commonly used for epilepsy, neuropathic pain, and [[restless legs syndrome]]. Gabapentinoids are often [[Sedation|sedating]], have [[Seizure suppression|anticonvulsant]] effects, and [[Anxiety suppression|suppress anxiety]]. Drugs in this class include [[gabapentin]], [[F-phenibut]], [[phenibut]] and, [[pregabalin]]. Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[benzodiazepine]]s, [[alcohol]] and [[opioid]]s.

=See also=

*[[Responsible use]]

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 {{Stub}}
-[[File:Gabapentinoidsstructure.png|thumbnail|Diagram showing the structural similarities of [[pregabalin]], [[gabapentin]] and [[GABA |gamma-aminobutyric acid]].]]
+[[File:Gabapentinoidsstructure.png|250px|thumbnail|Diagram showing the structural similarities of [[GABA|gamma-aminobutyric acid]] (GABA), [[pregabalin]] and [[gabapentin]].]]
-'''Gabapentinoids''' are a class of chemical compounds that are derivatives of [[GABA |gamma-aminobutyric acid]] which block α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels |channels]]. While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.
+'''Gabapentinoids''' are a class of chemical compounds that are derivatives of [[GABA|gamma-aminobutyric acid]] which block α2δ subunit-containing voltage-dependent calcium [[receptor#Ion_channels|channels]]. While all gabapentinoids block the α2δ channels, they also have unique pharmacological characteristics such as enzyme inhibition.
-Gabapentinoids are commonly used for epilepsy, neuropathic pain, and [[restless legs syndrome]]. Gabapentinoids are often [[Sedation |sedating]], have [[Seizure suppression |anticonvulsant]] effects, and [[Anxiety suppression |suppress anxiety]]. Drugs in this class include [[gabapentin]], [[F-phenibut]], [[phenibut]] and, [[pregabalin]]. Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[benzodiazepine |benzodiazepines]], [[alcohol]] and [[opioid |opioids]].
+Gabapentinoids are commonly used for epilepsy, neuropathic pain, and [[restless legs syndrome]]. Gabapentinoids are often [[Sedation|sedating]], have [[Seizure suppression|anticonvulsant]] effects, and [[Anxiety suppression|suppress anxiety]]. Drugs in this class include [[gabapentin]], [[F-phenibut]], [[phenibut]] and, [[pregabalin]]. Gabapentinoids can be dangerous when mixed with other [[depressants]] such as [[benzodiazepine]]s, [[alcohol]] and [[opioid]]s.
 =See also=
 *[[Responsible use]]