Butylone: Difference between revisions

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| ''[[Butylone/Summary|Summary sheet: Butylone]]''

|}

'''Butylone''' (also known as '''β-keto-''N''-methylbenzodioxolylbutanamine''', '''βk-MBDB''', or '''B1''') is a synthetic [[entactogen]] and [[psychoactive class::stimulant]] of the [[phenethylamine]] and [[~~chemical class::~~cathinone]] classes. Butylone is the β-keto analog of [[MBDB]] and the substituted methylenedioxy analogue of [[buphedrone]].

'''Butylone''' (also known as '''β-keto-''N''-methylbenzodioxolylbutanamine''', '''βk-MBDB''', or '''B1''') is a synthetic [[entactogen]] and [[psychoactive class::stimulant]] of the [[phenethylamine]] and [[Substituted cathinone|cathinone]] classes. Butylone is the β-keto analog of [[MBDB]] and the substituted methylenedioxy analogue of [[buphedrone]].

As a [[designer drug]], it is commonly sold on the street along with [[ethylone]] and [[butylone]] as a substitute or counterfeit for [[MDMA]] and [[methylone]] (all of which have collectively come to be referred to as "Molly") due to methylone's declining availability on the [[research chemical]]s market. However, in spite of behavioral and pharmacological similarities between butylone and MDMA, the observed subjective effects of both drugs are not completely identical. <ref name="urlCathinone | Ask Dr. Shulgin Online">{{cite web | url = http://www.cognitiveliberty.org/shulgin/adsarchive/cathinone.htm | title = Cathinone | Ask Dr. Shulgin Online }}</ref>

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==Chemistry==

Butylone, or '''β-keto-''N''-methylbenzodioxolylbutanamine''', is a synthetic molecule of the [[cathinone]] family. Cathinones are structurally similar to amphetamines in that they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional ethyl substitution at Rα. Cathinones such as butylone are alpha-methylated phenethylamines (i.e. [[amphetamine]]s) but differ from them with the addition of a ketone functional group (a carbonyl group at Rβ). Butylone contains a methyl substitution at RN, a substitution which is shared with [[MDEA]], [[ethylone]], [[4-MEC]], and certain other stimulants and entactogens. Additionally, butylone contains substitutions at R3 and R4 of the phenyl ring with oxygen groups. These oxygen groups are incorporated into a methylenedioxy ring through a methylene chain. Butylone shares this methylenedioxy ring with [[MDA]], [[MDAI]] and [[MDMA]].

Butylone, or '''β-keto-''N''-methylbenzodioxolylbutanamine''', is a synthetic molecule of the [[Substituted cathinone|cathinone]] family. Cathinones are structurally similar to amphetamines in that they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional ethyl substitution at Rα. Cathinones such as butylone are alpha-methylated phenethylamines (i.e. [[amphetamine]]s) but differ from them with the addition of a ketone functional group (a carbonyl group at Rβ). Butylone contains a methyl substitution at RN, a substitution which is shared with [[MDEA]], [[ethylone]], [[4-MEC]], and certain other stimulants and entactogens. Additionally, butylone contains substitutions at R3 and R4 of the phenyl ring with oxygen groups. These oxygen groups are incorporated into a methylenedioxy ring through a methylene chain. Butylone shares this methylenedioxy ring with [[MDA]], [[MDAI]] and [[MDMA]].

==Pharmacology==

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*[[Entactogens]]

*[[Stimulants]]

*[[~~Amphetamines~~]]

*[[Amphetamine]]

*[[Cathinones]]

*[[Substituted cathinone|Cathinones]]

*[[Mephedrone]]

*[[MDMA]]

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 | ''[[Butylone/Summary|Summary sheet: Butylone]]''
 |}
-'''Butylone''' (also known as '''β-keto-''N''-methylbenzodioxolylbutanamine''', '''βk-MBDB''', or '''B1''') is a synthetic [[entactogen]] and [[psychoactive class::stimulant]] of the [[phenethylamine]] and [[chemical class::cathinone]] classes. Butylone is the β-keto analog of [[MBDB]] and the substituted methylenedioxy analogue of [[buphedrone]].
+'''Butylone''' (also known as '''β-keto-''N''-methylbenzodioxolylbutanamine''', '''βk-MBDB''', or '''B1''') is a synthetic [[entactogen]] and [[psychoactive class::stimulant]] of the [[phenethylamine]] and [[Substituted cathinone|cathinone]] classes. Butylone is the β-keto analog of [[MBDB]] and the substituted methylenedioxy analogue of [[buphedrone]].
 As a [[designer drug]], it is commonly sold on the street along with [[ethylone]] and [[butylone]] as a substitute or counterfeit for [[MDMA]] and [[methylone]] (all of which have collectively come to be referred to as "Molly") due to methylone's declining availability on the [[research chemical]]s market. However, in spite of behavioral and pharmacological similarities between butylone and MDMA, the observed subjective effects of both drugs are not completely identical. <ref name="urlCathinone | Ask Dr. Shulgin Online">{{cite web | url = http://www.cognitiveliberty.org/shulgin/adsarchive/cathinone.htm | title = Cathinone &#124; Ask Dr. Shulgin Online }}</ref>
@@ Line 13: / Line 13: @@
 ==Chemistry==
-Butylone, or '''β-keto-''N''-methylbenzodioxolylbutanamine''', is a synthetic molecule of the [[cathinone]] family.  Cathinones are structurally similar to amphetamines in that they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional ethyl substitution at R<sub>α</sub>. Cathinones such as butylone are alpha-methylated phenethylamines (i.e. [[amphetamine]]s) but differ from them with the addition of a ketone functional group (a carbonyl group at R<sub>β</sub>). Butylone contains a methyl substitution at R<sub>N</sub>, a substitution which is shared with [[MDEA]], [[ethylone]], [[4-MEC]], and certain other stimulants and entactogens. Additionally, butylone contains substitutions at R<sub>3</sub> and R<sub>4</sub> of the phenyl ring with oxygen groups. These oxygen groups are incorporated into a methylenedioxy ring through a methylene chain. Butylone shares this methylenedioxy ring with [[MDA]], [[MDAI]] and [[MDMA]].
+Butylone, or '''β-keto-''N''-methylbenzodioxolylbutanamine''', is a synthetic molecule of the [[Substituted cathinone|cathinone]] family.  Cathinones are structurally similar to amphetamines in that they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional ethyl substitution at R<sub>α</sub>. Cathinones such as butylone are alpha-methylated phenethylamines (i.e. [[amphetamine]]s) but differ from them with the addition of a ketone functional group (a carbonyl group at R<sub>β</sub>). Butylone contains a methyl substitution at R<sub>N</sub>, a substitution which is shared with [[MDEA]], [[ethylone]], [[4-MEC]], and certain other stimulants and entactogens. Additionally, butylone contains substitutions at R<sub>3</sub> and R<sub>4</sub> of the phenyl ring with oxygen groups. These oxygen groups are incorporated into a methylenedioxy ring through a methylene chain. Butylone shares this methylenedioxy ring with [[MDA]], [[MDAI]] and [[MDMA]].
 ==Pharmacology==
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 *[[Entactogens]]
 *[[Stimulants]]
-*[[Amphetamines]]
+*[[Amphetamine]]
-*[[Cathinones]]
+*[[Substituted cathinone|Cathinones]]
 *[[Mephedrone]]
 *[[MDMA]]