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2C-B-FLY: Difference between revisions
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{{Further|Serotonergic psychedelic}} | {{Further|Serotonergic psychedelic}} | ||
Little is known about how the totality of its effects are produced, 2C-B-FLY's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. | Little is known about how the totality of its effects are produced, 2C-B-FLY's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. | ||
{| class="wikitable" | |||
|- | |||
! Site !! Binding Affinity Ki (nM)<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/</ref> | |||
|- | |||
| 5-HT<sub>1A</sub> || 147 | |||
|- | |||
| 5-HT<sub>1B</sub> || 185 | |||
|- | |||
| 5-HT<sub>1E</sub> || 109.9 | |||
|- | |||
| 5-HT<sub>2A</sub> || 11.6 | |||
|- | |||
| 5-HT<sub>2B</sub> || 0.9 | |||
|- | |||
| 5-HT<sub>2C</sub> || 10.6 | |||
|- | |||
| 5-HT<sub>6</sub> || 150 | |||
|- | |||
| 5-HT<sub>7</sub> || 606 | |||
|- | |||
| α<sub>2A</sub> || 145 | |||
|- | |||
| α<sub>2C</sub> || 233 | |||
|- | |||
| M<sub>3</sub> || 339 | |||
|- | |||
| M<sub>4</sub> || 520 | |||
|- | |||
| M<sub>5</sub> || 873 | |||
|- | |||
| CB<sub>2</sub> || 8974 | |||
|} | |||
However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation. | However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation. | ||