Psychedelic: Difference between revisions

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Tolerance to the effects of most psychedelics builds [[Time to full tolerance::almost immediately after ingestion]] and hits a peak once the effects wear off. After that, it takes about 5-7 days for the tolerance to be reduced to half and 1-2 weeks to be back at baseline (in the absence of further consumption). Most psychedelics present cross tolerance with [[cross-tolerance:: all [[psychedelics]]]], meaning they will have a reduced effect.

Notable exceptions to this include [[DMT]] and related tryptamines like [[DPT]] and [[MET]], which are thought to produce little to no tolerance or cross-tolerance.

Notable exceptions to this include [[DMT]] and related base tryptamines like [[DPT]] and [[MET]], which are thought to produce little to no tolerance or cross-tolerance.

Another exception includes psychedelic [[phenethylamines]] like [[2C-B]]. While the exact mechanism is not understood, generally tolerance is thought to rise immediately, but does not reach a peak unless with prolonged and repeated use. This means that the immediate tolerance does not rise as high as with [[lysergamides]] or [[tryptamines]] and can wear off faster and can be reduced to half within 1-2 days in the absence of further consumption. Mostly there will be less psychedelic and more stimulating effects.

@@ Line 578: / Line 578: @@
 Tolerance to the effects of most psychedelics builds [[Time to full tolerance::almost immediately after ingestion]] and hits a peak once the effects wear off. After that, it takes about 5-7 days for the tolerance to be reduced to half and 1-2 weeks to be back at baseline (in the absence of further consumption). Most psychedelics present cross tolerance with [[cross-tolerance:: all [[psychedelics]]]], meaning they will have a reduced effect.
-Notable exceptions to this include [[DMT]] and related tryptamines like [[DPT]] and [[MET]], which are thought to produce little to no tolerance or cross-tolerance.
+Notable exceptions to this include [[DMT]] and related base tryptamines like [[DPT]] and [[MET]], which are thought to produce little to no tolerance or cross-tolerance.
 Another exception includes psychedelic [[phenethylamines]] like [[2C-B]]. While the exact mechanism is not understood, generally tolerance is thought to rise immediately, but does not reach a peak unless with prolonged and repeated use. This means that the immediate tolerance does not rise as high as with [[lysergamides]] or [[tryptamines]] and can wear off faster and can be reduced to half within 1-2 days in the absence of further consumption. Mostly there will be less psychedelic and more stimulating effects.