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Research chemicals: Difference between revisions
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The safety profile of research chemicals is generally unknown due to a lack of medical studies. There is little to no information on the toxicity, negative health risks, long-term side effects, or lethal dosage of these chemicals, which make their use more risky than the use of more common, well-studied substances. It is for these reasons that taking these chemicals for extended periods of time, binging on them, and taking excessive doses is strongly discouraged. | The safety profile of research chemicals is generally unknown due to a lack of medical studies. There is little to no information on the toxicity, negative health risks, long-term side effects, or lethal dosage of these chemicals, which make their use more risky than the use of more common, well-studied substances. It is for these reasons that taking these chemicals for extended periods of time, binging on them, and taking excessive doses is strongly discouraged. | ||
In terms of known risk factors, common issues for research chemicals include the the mislabeling, misidentification, and misrepresentation of products; the adulteration of other compounds; and issues of purity.<ref name="erowid">Experimental & Research Chemicals (Synthetic Drugs, Novel Psychoactive Substances, New Psychoactive Substances, NPS, Replacement Psychoactives) (Erowid) | https://www.erowid.org/psychoactives/research_chems/</ref> Combining research chemicals presents a risk due to the lack of research and understanding of the drugs' pharmacology. For example, if a research chemical has [[MAOI]] effects (like 2C-T-7), this could make it dangerous to combine it with other [[MAOI]]s, [[ | In terms of known risk factors, common issues for research chemicals include the the mislabeling, misidentification, and misrepresentation of products; the adulteration of other compounds; and issues of purity.<ref name="erowid">Experimental & Research Chemicals (Synthetic Drugs, Novel Psychoactive Substances, New Psychoactive Substances, NPS, Replacement Psychoactives) (Erowid) | https://www.erowid.org/psychoactives/research_chems/</ref> Combining research chemicals presents a risk due to the lack of research and understanding of the drugs' pharmacology. For example, if a research chemical has [[MAOI]] effects (like 2C-T-7), this could make it dangerous to combine it with other [[MAOI]]s, [[stimulant]]s and certain substances which release [[serotonin]] or [[dopamine]]. It is recommended to avoid blends or branded products if the active psychoactive compounds are not listed on the labelling.<ref name="tripsit">Research Chemicals (Tripsit) | https://wiki.tripsit.me/wiki/Research_Chemicals</ref> | ||
Several fatal overdoses have occurred due to [[Bromo-DragonFLY]] accidentally being mislabelled by online vendors as both [[2C-B-Fly]]<ref name="2cbfly">Information on Reported Deaths Related to 2C-B-Fly Misidentified Substance is Most Likely Bromo-dragonfly by the Erowid Crew v1.6 - Nov 9, 2009 | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref> and [[2C-E]].<ref name="2ce">Bromo-Dragonfly Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/bromo_dragonfly/bromo_dragonfly_death.shtml</ref><ref name="2ce2">Second Victim Dies After Taking Designer Drug In Konawa | http://www.newson6.com/story/14641463/second-victim-dies-after-taking-designer-drug-in-konawa</ref> The former is active in the 200-800ug range and is significantly more potent than 2C-E. Situations like this can be avoided by simply dosing a minuscule amount of a drug (roughly 0.5 milligrams) and waiting for several hours. It is recommended to do this for all new batches of drugs that you do not completely trust. | Several fatal overdoses have occurred due to [[Bromo-DragonFLY]] accidentally being mislabelled by online vendors as both [[2C-B-Fly]]<ref name="2cbfly">Information on Reported Deaths Related to 2C-B-Fly Misidentified Substance is Most Likely Bromo-dragonfly by the Erowid Crew v1.6 - Nov 9, 2009 | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref> and [[2C-E]].<ref name="2ce">Bromo-Dragonfly Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/bromo_dragonfly/bromo_dragonfly_death.shtml</ref><ref name="2ce2">Second Victim Dies After Taking Designer Drug In Konawa | http://www.newson6.com/story/14641463/second-victim-dies-after-taking-designer-drug-in-konawa</ref> The former is active in the 200-800ug range and is significantly more potent than 2C-E. Situations like this can be avoided by simply dosing a minuscule amount of a drug (roughly 0.5 milligrams) and waiting for several hours. It is recommended to do this for all new batches of drugs that you do not completely trust. | ||
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====Psychedelics==== | ====Psychedelics==== | ||
*'''[[AMT]]''' - Deaths from AMT are rare<ref name="amt">AMT (Alphamethyltryptamine, IT-290) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/amt/amt_death.shtml</ref><ref name="amt2">Boland DM, Andollo W, Hime GW, Hearn WL. “Fatality due to acute alpha-methyltryptamine intoxication”. J Anal Toxicol. 2005 Jul-Aug;29(5):394-7. | https://www.erowid.org/references/refs_view.php?ID=6603</ref> but, as a powerful [[monoamine]] [[reuptake inhibitor]] (MRI), injury could occur when excessive doses are taken or when it is taken with drugs such as [[MAOIs]], [[RIMA]]s, [[ | *'''[[AMT]]''' - Deaths from AMT are rare<ref name="amt">AMT (Alphamethyltryptamine, IT-290) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/amt/amt_death.shtml</ref><ref name="amt2">Boland DM, Andollo W, Hime GW, Hearn WL. “Fatality due to acute alpha-methyltryptamine intoxication”. J Anal Toxicol. 2005 Jul-Aug;29(5):394-7. | https://www.erowid.org/references/refs_view.php?ID=6603</ref> but, as a powerful [[monoamine]] [[reuptake inhibitor]] (MRI), injury could occur when excessive doses are taken or when it is taken with drugs such as [[MAOIs]], [[RIMA]]s, [[stimulant]]s and any substance which act as a [[releasing agent]] or [[reuptake inhibitor]] of [[neurotransmitters]] such as [[serotonin]] and [[dopamine]].<ref>Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | http://bja.oxfordjournals.org/content/95/4/434</ref> | ||
*'''[[DOC]]''' - There is one reported death from DOC, however, the toxicology report hasn't been released nor has the presence of DOC been confirmed.<ref>DOC (2,5-Dimethoxy-ChloroAmphetamine) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/doc/doc_death.shtml</ref> | *'''[[DOC]]''' - There is one reported death from DOC, however, the toxicology report hasn't been released nor has the presence of DOC been confirmed.<ref>DOC (2,5-Dimethoxy-ChloroAmphetamine) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/doc/doc_death.shtml</ref> | ||
*'''[[2C-T-7]]''' - There have been at least three reported deaths related to 2C-T-7 use at insufflated (nasal) doses of 30 mg or more<ref name="one">A Reported 2C-T-7 Death by Erowid July 2003 | https://www.erowid.org/chemicals/2ct7/2ct7_death1.shtml</ref><ref name="two">Second Reported 2C-T-7 Death by Erowid Apr 2, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death2.shtml</ref> or combined with stimulants such as [[MDMA]].<ref name="three">Third Confirmed 2C-T-7 Death by Erowid Apr 10, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death3.shtml</ref> It is not recommended to [[insufflate]] (snort) this drug or combine it with [[MAOI]]s, [[ | *'''[[2C-T-7]]''' - There have been at least three reported deaths related to 2C-T-7 use at insufflated (nasal) doses of 30 mg or more<ref name="one">A Reported 2C-T-7 Death by Erowid July 2003 | https://www.erowid.org/chemicals/2ct7/2ct7_death1.shtml</ref><ref name="two">Second Reported 2C-T-7 Death by Erowid Apr 2, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death2.shtml</ref> or combined with stimulants such as [[MDMA]].<ref name="three">Third Confirmed 2C-T-7 Death by Erowid Apr 10, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death3.shtml</ref> It is not recommended to [[insufflate]] (snort) this drug or combine it with [[MAOI]]s, [[stimulant]]s and certain substances which releases [[serotonin]] or [[dopamine]] because 2C-T-7 may possibly have [[MAOI]] effects.<ref>Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109</ref> | ||
*'''[[25I-NBOMe]]'''<ref name="one">25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml</ref> | *'''[[25I-NBOMe]]'''<ref name="one">25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml</ref> | ||
*'''[[25B-NBOMe]]'''<ref name="three">Other or Unknown NBOMe Compound Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/nbome/nbome_death.shtml</ref> | *'''[[25B-NBOMe]]'''<ref name="three">Other or Unknown NBOMe Compound Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/nbome/nbome_death.shtml</ref> | ||