Metizolam: Difference between revisions

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''''''Metizolam'''''' (also known as '''desmethyletizolam''') is a short-acting [[psychoactive]] drug of the [[thienodiazepine]] class that is closely related to etizolam.[1][2][3] It has been shown to produce [[depressant]], anxiolytic~~, sedative, hypnotic, muscle relaxant~~, [[~~anticonvulsant~~]], ~~and amnestic effects. It is a~~ [[~~thienodiazepine~~]] ~~that is closely related to etizolam.~~[1][2][3] ~~Metizolam~~, ~~like~~ [[~~benzodiazepines~~]], ~~binds to modulatory sites on the GABA~~ [[~~gamma-aminobutyric acid~~]] ~~receptors~~. This compound ~~is not recognised as a controlled substance in many parts~~ of ~~the world, leading~~ to its ~~rise in popularity~~ as a ~~product of many [[~~research chemical]] vendors.

''''''Metizolam'''''' (also known as '''desmethyletizolam''') is a short-acting [[psychoactive]] drug of the [[thienodiazepine]] class that is closely related to [[etizolam]].[1][2][3] It has a 60% longer half life and 50% less potency than etizolam. It has been shown by annecdotal reports to produce [[depressant]], [[anxiolytic]], [[sedative]], [[hypnotic]], [[muscle relaxant]], [[anticonvulsant]], and [[amnestic]] effects.

This compound has little to no history of human usage prior to its release as a grey area research chemical by online vendors in September 2015.

Metizolam has a relatively fast onset of action and symptomatic relief. 1mg of metizolam is approximately equivalent to 10mg [[diazepam]]. For anxiety disorders associated with depression, 1 mg can be administered several times over the course of a day. Smaller doses may alleviate symptoms of panic and can be used before bed for relief of insomnia.

==Chemistry==

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Tolerance will develop to the sedative-hypnotic effects within a couple of days of repeated administration. Abrupt discontinuation of metizolam following regular dosing over several days can result in a withdrawal phase which includes rebound symptoms such as increased anxiety and insomnia. It is possible to gradually reduce the dose over the course of several days, which will lengthen the duration of the withdrawal period, but reduce the perceived intensity.

[[Benzodiazepine#Discontinuation|~~Benzodiazepine~~ discontinuation]] is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of seizure following discontinuation. Drugs which lower the seizure threshold such as [[tramadol]] should be avoided during withdrawal.

[[Benzodiazepine#Discontinuation|Thienzodiazepine discontinuation]] is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of seizure following discontinuation. Drugs which lower the seizure threshold such as [[tramadol]] should be avoided during withdrawal.

===Dangerous interactions===

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances also potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the [https://www.youtube.com/watch?v=uCDa-AhrjHo recovery position] or have a friend move them into it.

*'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the [https://www.youtube.com/watch?v=uCDa-AhrjHo recovery position] or have a friend move them into it.

*'''[[Stimulants]]''' - It is dangerous to combine ~~benzodiazepines~~ with [[stimulants]] due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of ~~benzodiazepines~~ will be significantly increased, leading to intensified [[disinhibition]] as well as [[benzodiazepine#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only dosing a certain amount of ~~benzodiazepines~~ per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.

*'''[[Stimulants]]''' - It is dangerous to combine thienzodiazepines with [[stimulants]] due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of thienzodiazepines will be significantly increased, leading to intensified [[disinhibition]] as well as [[benzodiazepine#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only dosing a certain amount of thienzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.

==Legal issues==

Metizolam is currently a grey area compound within most parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

==Preparation methods==

@@ Line 8: / Line 8: @@
 {{SubstanceBox/Metizolam}}
-''''''Metizolam'''''' (also known as '''desmethyletizolam''') is a short-acting [[psychoactive]] drug of the [[thienodiazepine]] class that is closely related to etizolam.[1][2][3] It has been shown to produce [[depressant]], anxiolytic, sedative, hypnotic, muscle relaxant, [[anticonvulsant]], and amnestic effects. It is a [[thienodiazepine]] that is closely related to etizolam.[1][2][3] Metizolam, like [[benzodiazepines]], binds to modulatory sites on the GABA [[gamma-aminobutyric acid]] receptors. This compound is not recognised as a controlled substance in many parts of the world, leading to its rise in popularity as a product of many [[research chemical]] vendors.
+''''''Metizolam'''''' (also known as '''desmethyletizolam''') is a short-acting [[psychoactive]] drug of the [[thienodiazepine]] class that is closely related to [[etizolam]].[1][2][3] It has a 60% longer half life and 50% less potency than etizolam. It has been shown by annecdotal reports to produce [[depressant]], [[anxiolytic]], [[sedative]], [[hypnotic]], [[muscle relaxant]], [[anticonvulsant]], and [[amnestic]] effects.
+This compound has little to no history of human usage prior to its release as a grey area research chemical by online vendors in September 2015.
-Metizolam has a relatively fast onset of action and symptomatic relief. 1mg of metizolam is approximately equivalent to 10mg [[diazepam]]. For anxiety disorders associated with depression, 1 mg can be administered several times over the course of a day. Smaller doses may alleviate symptoms of panic and can be used before bed for relief of insomnia.
 ==Chemistry==
 {{chemistry}}
@@ Line 48: / Line 49: @@
 Tolerance will develop to the sedative-hypnotic effects within a couple of days of repeated administration. Abrupt discontinuation of metizolam following regular dosing over several days can result in a withdrawal phase which includes rebound symptoms such as increased anxiety and insomnia. It is possible to gradually reduce the dose over the course of several days, which will lengthen the duration of the withdrawal period, but reduce the perceived intensity.
-[[Benzodiazepine#Discontinuation|Benzodiazepine discontinuation]] is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of seizure following discontinuation. Drugs which lower the seizure threshold such as [[tramadol]] should be avoided during withdrawal.
+[[Benzodiazepine#Discontinuation|Thienzodiazepine discontinuation]] is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of seizure following discontinuation. Drugs which lower the seizure threshold such as [[tramadol]] should be avoided during withdrawal.
 ===Dangerous interactions===
 Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
 *'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances also potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the [https://www.youtube.com/watch?v=uCDa-AhrjHo recovery position] or have a friend move them into it.
 *'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the [https://www.youtube.com/watch?v=uCDa-AhrjHo recovery position] or have a friend move them into it.
-*'''[[Stimulants]]''' -  It is dangerous to combine benzodiazepines with [[stimulants]] due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified [[disinhibition]] as well as [[benzodiazepine#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.
+*'''[[Stimulants]]''' -  It is dangerous to combine thienzodiazepines with [[stimulants]] due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of thienzodiazepines will be significantly increased, leading to intensified [[disinhibition]] as well as [[benzodiazepine#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only dosing a certain amount of thienzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.
 ==Legal issues==
+{{legalStub}}
 Metizolam is currently a grey area compound within most parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.
 ==Preparation methods==