4-AcO-DET: Difference between revisions

Line 6:

| ''[[4-AcO-DET/Summary|Summary sheet: 4-AcO-DET]]''

|}

'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine'''; also known as '''Ethacetin''') is an obscure synthetic [[psychoactive class::psychedelic]] [[chemical class::tryptamine]]. It is the acetylated form of [[4-HO-DET]] (also known as '''Ethocin''') and is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]]. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]), in theory being inactive until they are deacetylated, although there is on-going ~~debate~~ as to whether they possess their own intrinsic activity.{{citation needed}}

'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine'''; also known as '''Ethacetin''') is an obscure synthetic [[psychoactive class::psychedelic]] [[chemical class::tryptamine]]. It is the acetylated form of [[4-HO-DET]] (also known as '''Ethocin''') and is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]]. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]), in theory being inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might possess their own intrinsic activity.{{citation needed}}

There is very little information on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>http://www.sciencedirect.com/science/article/pii/S0039914008005808</ref><ref>http://link.springer.com/article/10.1007%2Fs00044-011-9794-y</ref> Today it is either used recreationally or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. It remains relatively ~~uncommon~~ and has very little history of human usage.

There is very little information on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>http://www.sciencedirect.com/science/article/pii/S0039914008005808</ref><ref>http://link.springer.com/article/10.1007%2Fs00044-011-9794-y</ref> Today it is either used recreationally as a [[designer drug]] or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. It remains relatively rare and has very little documented history of human usage.

==Chemistry==

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone (DET).

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone ([[DET]]).

4-AcO-DET is the N-substituted diethyl ~~homologue~~ of [[4-HO-DMT]] ('''Psilocin'''). 4-AcO-DETis the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>4-Acetoxy-DET - PubChem | https://pubchem.ncbi.nlm.nih.gov/compound/3-_2-_Diethylamino_ethyl_-1H-indol-4-yl_acetate#section=Top</ref>

4-AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] ('''Psilocin'''). 4-AcO-DETis the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>4-Acetoxy-DET - PubChem | https://pubchem.ncbi.nlm.nih.gov/compound/3-_2-_Diethylamino_ethyl_-1H-indol-4-yl_acetate#section=Top</ref>

==Pharmacology==

@@ Line 6: / Line 6: @@
 | ''[[4-AcO-DET/Summary|Summary sheet: 4-AcO-DET]]''
 |}
-'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine'''; also known as '''Ethacetin''') is an obscure synthetic [[psychoactive class::psychedelic]] [[chemical class::tryptamine]]. It is the acetylated form of [[4-HO-DET]] (also known as '''Ethocin''') and is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]]. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]), in theory being inactive until they are deacetylated, although there is on-going debate as to whether they possess their own intrinsic activity.{{citation needed}}
+'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine'''; also known as '''Ethacetin''') is an obscure synthetic [[psychoactive class::psychedelic]] [[chemical class::tryptamine]]. It is the acetylated form of [[4-HO-DET]] (also known as '''Ethocin''') and is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]]. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]), in theory being inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might possess their own intrinsic activity.{{citation needed}}
-There is very little information on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>http://www.sciencedirect.com/science/article/pii/S0039914008005808</ref><ref>http://link.springer.com/article/10.1007%2Fs00044-011-9794-y</ref> Today it is either used recreationally or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. It remains relatively uncommon and has very little history of human usage.
+There is very little information on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>http://www.sciencedirect.com/science/article/pii/S0039914008005808</ref><ref>http://link.springer.com/article/10.1007%2Fs00044-011-9794-y</ref> Today it is either used recreationally as a [[designer drug]] or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. It remains relatively rare and has very little documented history of human usage.
 ==Chemistry==
--AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R<sub>4</sub> of its indole heterocycle with an acetoxy (AcO) functional group CH<sub>3</sub>COO−. It also contains isopropyl and methyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone (DET).
+-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R<sub>4</sub> of its indole heterocycle with an acetoxy (AcO) functional group CH<sub>3</sub>COO−. It also contains isopropyl and methyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DET]]).
--AcO-DET is the N-substituted diethyl homologue of [[4-HO-DMT]] ('''Psilocin'''). 4-AcO-DETis the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>4-Acetoxy-DET - PubChem | https://pubchem.ncbi.nlm.nih.gov/compound/3-_2-_Diethylamino_ethyl_-1H-indol-4-yl_acetate#section=Top</ref>
+-AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] ('''Psilocin'''). 4-AcO-DETis the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>4-Acetoxy-DET - PubChem | https://pubchem.ncbi.nlm.nih.gov/compound/3-_2-_Diethylamino_ethyl_-1H-indol-4-yl_acetate#section=Top</ref>
 ==Pharmacology==