Substance P: Difference between revisions

[[File:Substance P.svg|thumbnail|Substance P.]]

'''Substance P''' (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator affecting the '''neurokinin receptors'''. It has most closely been associated with nociception (pain perception),<ref name="pain">Substance P: Transmitter of nociception (minireview) | https://www.sav.sk/journals/endo/full/er0400e.pdf</ref> but seems to have a wide range of effects, including an important role in nausea and emesis (vomiting); the rewarding effects of opiates; and likely in regulating stress responses and anxiety/depression-related behavior.<ref name="mood">The role of substance P in stress and anxiety responses | http://search.proquest.com/docview/68938022</ref> SP is found throughout the body, both in the brain, in peripheral nerve endings and in the spine. The full extent of its involvement in neurotransmission, and its possible therapeutic or recreational implications, is unclear.