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MAOI: Difference between revisions
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**[[#Nonselective_MAO-A_and_MAO-B_inhibitors|Cannabinoids]]: Cannabinoids are lipophilic. For example, THC has been detected in heavy cannabis users after 77 days of drug abstinence (Ellis et al., 1985).<ref>{{cite journal | vauthors=((Ellis, G. M.)), ((Mann, M. A.)), ((Judson, B. A.)), ((Schramm, N. T.)), ((Tashchian, A.)) | journal=Clinical Pharmacology and Therapeutics | title=Excretion patterns of cannabinoid metabolites after last use in a group of chronic users | volume=38 | issue=5 | pages=572–578 | date= November 1985 | issn=0009-9236 | doi=10.1038/clpt.1985.226}}</ref> | **[[#Nonselective_MAO-A_and_MAO-B_inhibitors|Cannabinoids]]: Cannabinoids are lipophilic. For example, THC has been detected in heavy cannabis users after 77 days of drug abstinence (Ellis et al., 1985).<ref>{{cite journal | vauthors=((Ellis, G. M.)), ((Mann, M. A.)), ((Judson, B. A.)), ((Schramm, N. T.)), ((Tashchian, A.)) | journal=Clinical Pharmacology and Therapeutics | title=Excretion patterns of cannabinoid metabolites after last use in a group of chronic users | volume=38 | issue=5 | pages=572–578 | date= November 1985 | issn=0009-9236 | doi=10.1038/clpt.1985.226}}</ref> | ||
**SSRIs: Because of the extended half-life of norfluoxetine, a '''minimum of 5 weeks''' should lapse between stopping fluoxetine (20 mg/day) and starting an MAOI. With higher doses the interval should be longer. For example, a serotonin syndrome was reported following a 6-weeks washout in a patient who had been given fluoxetine (80 mg/day).<ref>{{cite book | vauthors=((Janicak, P. G.)), ((Marder, S. R.)), ((Pavuluri, M. N.)) | date=26 December 2011 | title=Principles and Practice of Psychopharmacotherapy | publisher=Lippincott Williams & Wilkins | isbn=9781451178777}}</ref> | **SSRIs: Because of the extended half-life of norfluoxetine, a <span style="color:red">'''minimum of 5 weeks'''</span> should lapse between stopping fluoxetine (20 mg/day) and starting an MAOI. With higher doses the interval should be longer. For example, a serotonin syndrome was reported following a 6-weeks washout in a patient who had been given fluoxetine (80 mg/day).<ref>{{cite book | vauthors=((Janicak, P. G.)), ((Marder, S. R.)), ((Pavuluri, M. N.)) | date=26 December 2011 | title=Principles and Practice of Psychopharmacotherapy | publisher=Lippincott Williams & Wilkins | isbn=9781451178777}}</ref> | ||
*Tolerance from heavy substance use or therapy may cause [https://en.wikipedia.org/wiki/Post-acute-withdrawal_syndrome post-acute-withdrawal syndrome] (PAWS). The condition gradually improves over a period of time which can range from six months to several years in more severe cases.<ref>{{cite journal | author=Roberts AJ |author2=Heyser CJ |author3=Cole M |author4=Griffin P |author5=Koob GF |date=June 2000 | title=Excessive ethanol drinking following a history of dependence: animal model of allostasis | journal =Neuropsychopharmacology | volume=22 | issue=6 | pages=581–94 | pmid=10788758 | doi=10.1016/S0893-133X(99)00167-0}}</ref><ref>{{cite journal | vauthors=De Soto CB, O'Donnell WE, De Soto JL |date=October 1989 | title =Long-term recovery in alcoholics | journal =Alcohol Clin Exp Res | volume =13 | issue =5 | pages =693–7 | pmid =2688470 | doi =10.1111/j.1530-0277.1989.tb00406.x }}</ref> | *Tolerance from heavy substance use or therapy may cause [https://en.wikipedia.org/wiki/Post-acute-withdrawal_syndrome post-acute-withdrawal syndrome] (PAWS). The condition gradually improves over a period of time which can range from six months to several years in more severe cases.<ref>{{cite journal | author=Roberts AJ |author2=Heyser CJ |author3=Cole M |author4=Griffin P |author5=Koob GF |date=June 2000 | title=Excessive ethanol drinking following a history of dependence: animal model of allostasis | journal =Neuropsychopharmacology | volume=22 | issue=6 | pages=581–94 | pmid=10788758 | doi=10.1016/S0893-133X(99)00167-0}}</ref><ref>{{cite journal | vauthors=De Soto CB, O'Donnell WE, De Soto JL |date=October 1989 | title =Long-term recovery in alcoholics | journal =Alcohol Clin Exp Res | volume =13 | issue =5 | pages =693–7 | pmid =2688470 | doi =10.1111/j.1530-0277.1989.tb00406.x }}</ref> | ||