MAOI: Difference between revisions - PsychonautWiki Archive

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When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.

~~===Tyramine===~~

Tyramine is physiologically metabolized by monamine oxidases (primarily MAO-A), FMO3, PNMI, DBH and CYP2D6.<ref>https://www.ajol.info/index.php/jomip/article/view/213795</ref><ref>https://pubmed.ncbi.nlm.nih.gov/31736764/</ref> Tyramine and dopamine are metabolized by both MAO-A and MAO-B. It has been established that hypertensive crises are a consequence of MAO-A inhibition (Youdim et al. 1988; Laux et al. 1995).<ref>https://pubmed.ncbi.nlm.nih.gov/10063483/</ref> However, eating foods rich in tyramine while taking high doses of MAO-B inhibitors can cause a sudden increase in blood pressure.<ref>https://www.parkinsons.org.uk/information-and-support/mao-b-inhibitors-rasagiline-selegiline-safinamide</ref>

Tyramine causes hypertensive crises after MAO inhibition aka the "cheese effect" or "cheese crisis". Using a MAO inhibitor (MAOI), the intake of approximately 10 to 25 mg of tyramine is required for a severe reaction compared to 6 to 10 mg for a mild reaction.<ref>{{cite journal | vauthors=((Sathyanarayana Rao, T. S.)), ((Yeragani, V. K.)) | journal=Indian Journal of Psychiatry | title=Hypertensive crisis and cheese | volume=51 | issue=1 | pages=65–66 | date= 2009 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738414/ | issn=0019-5545 | doi=10.4103/0019-5545.44910}}</ref> Tyramine rich food should also be avoided by people prone to headache and migraine.

====Psychoactive substances====

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====Tyramine====

Tyramine is physiologically metabolized by monamine oxidases (primarily MAO-A), FMO3, PNMI, DBH and CYP2D6.<ref>https://www.ajol.info/index.php/jomip/article/view/213795</ref><ref>https://pubmed.ncbi.nlm.nih.gov/31736764/</ref> Tyramine and dopamine are metabolized by both MAO-A and MAO-B. It has been established that hypertensive crises are a consequence of MAO-A inhibition (Youdim et al. 1988; Laux et al. 1995).<ref>https://pubmed.ncbi.nlm.nih.gov/10063483/</ref> However, eating foods rich in tyramine while taking high doses of MAO-B inhibitors can cause a sudden increase in blood pressure.<ref>https://www.parkinsons.org.uk/information-and-support/mao-b-inhibitors-rasagiline-selegiline-safinamide</ref>

Tyramine causes hypertensive crises after MAO inhibition aka the "cheese effect" or "cheese crisis". Using a MAO inhibitor (MAOI), the intake of approximately 10 to 25 mg of tyramine is required for a severe reaction compared to 6 to 10 mg for a mild reaction.<ref>{{cite journal | vauthors=((Sathyanarayana Rao, T. S.)), ((Yeragani, V. K.)) | journal=Indian Journal of Psychiatry | title=Hypertensive crisis and cheese | volume=51 | issue=1 | pages=65–66 | date= 2009 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738414/ | issn=0019-5545 | doi=10.4103/0019-5545.44910}}</ref> Tyramine rich food should also be avoided by people prone to headache and migraine.

==Reduced bio-availability==

@@ Line 244: / Line 244: @@
 When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.
-===Tyramine===
-Tyramine is physiologically metabolized by monamine oxidases (primarily MAO-A), FMO3, PNMI, DBH and CYP2D6.<ref>https://www.ajol.info/index.php/jomip/article/view/213795</ref><ref>https://pubmed.ncbi.nlm.nih.gov/31736764/</ref> Tyramine and dopamine are metabolized by both MAO-A and MAO-B. It has been established that hypertensive crises are a consequence of MAO-A inhibition (Youdim et al. 1988; Laux et al. 1995).<ref>https://pubmed.ncbi.nlm.nih.gov/10063483/</ref> However, eating foods rich in tyramine while taking high doses of MAO-B inhibitors can cause a sudden increase in blood pressure.<ref>https://www.parkinsons.org.uk/information-and-support/mao-b-inhibitors-rasagiline-selegiline-safinamide</ref>
-Tyramine causes hypertensive crises after MAO inhibition aka the "cheese effect" or "cheese crisis". Using a MAO inhibitor (MAOI), the intake of approximately 10 to 25 mg of tyramine is required for a severe reaction compared to 6 to 10 mg for a mild reaction.<ref>{{cite journal | vauthors=((Sathyanarayana Rao, T. S.)), ((Yeragani, V. K.)) | journal=Indian Journal of Psychiatry | title=Hypertensive crisis and cheese | volume=51 | issue=1 | pages=65–66 | date= 2009 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738414/ | issn=0019-5545 | doi=10.4103/0019-5545.44910}}</ref> Tyramine rich food should also be avoided by people prone to headache and migraine.
 ====Psychoactive substances====
@@ Line 401: / Line 396: @@
 {{DangerousInteractions/Intro}}
 {{DangerousInteractions/MAOIs}}
+====Tyramine====
+Tyramine is physiologically metabolized by monamine oxidases (primarily MAO-A), FMO3, PNMI, DBH and CYP2D6.<ref>https://www.ajol.info/index.php/jomip/article/view/213795</ref><ref>https://pubmed.ncbi.nlm.nih.gov/31736764/</ref> Tyramine and dopamine are metabolized by both MAO-A and MAO-B. It has been established that hypertensive crises are a consequence of MAO-A inhibition (Youdim et al. 1988; Laux et al. 1995).<ref>https://pubmed.ncbi.nlm.nih.gov/10063483/</ref> However, eating foods rich in tyramine while taking high doses of MAO-B inhibitors can cause a sudden increase in blood pressure.<ref>https://www.parkinsons.org.uk/information-and-support/mao-b-inhibitors-rasagiline-selegiline-safinamide</ref>
+Tyramine causes hypertensive crises after MAO inhibition aka the "cheese effect" or "cheese crisis". Using a MAO inhibitor (MAOI), the intake of approximately 10 to 25 mg of tyramine is required for a severe reaction compared to 6 to 10 mg for a mild reaction.<ref>{{cite journal | vauthors=((Sathyanarayana Rao, T. S.)), ((Yeragani, V. K.)) | journal=Indian Journal of Psychiatry | title=Hypertensive crisis and cheese | volume=51 | issue=1 | pages=65–66 | date= 2009 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738414/ | issn=0019-5545 | doi=10.4103/0019-5545.44910}}</ref> Tyramine rich food should also be avoided by people prone to headache and migraine.
 ==Reduced bio-availability==