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Psilocybin mushrooms: Difference between revisions
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A low dose (0.1 mg/kg) of psilocybin produced a trend toward increased neurogenesis in the mouse hippocampus 2 weeks after its administration, while a high dose (1 mg/kg) significantly decreased neurogenesis. These results suggest that the effects of psilocybin on neurogenesis are dose- and time-related.<ref name="pmid=27354908">{{cite journal |last1=Dos Santos |first1=RG |last2=Osório |first2=FL |last3=Crippa |first3=JA |last4=Riba |first4=J |last5=Zuardi |first5=AW |last6=Hallak |first6=JE |title=Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years. |journal=Therapeutic advances in psychopharmacology |date=June 2016 |volume=6 |issue=3 |pages=193-213 |doi=10.1177/2045125316638008 |pmid=27354908 |pmc=PMC4910400}}</ref> | A low dose (0.1 mg/kg) of psilocybin produced a trend toward increased neurogenesis in the mouse hippocampus 2 weeks after its administration, while a high dose (1 mg/kg) significantly decreased neurogenesis. These results suggest that the effects of psilocybin on neurogenesis are dose- and time-related.<ref name="pmid=27354908">{{cite journal |last1=Dos Santos |first1=RG |last2=Osório |first2=FL |last3=Crippa |first3=JA |last4=Riba |first4=J |last5=Zuardi |first5=AW |last6=Hallak |first6=JE |title=Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years. |journal=Therapeutic advances in psychopharmacology |date=June 2016 |volume=6 |issue=3 |pages=193-213 |doi=10.1177/2045125316638008 |pmid=27354908 |pmc=PMC4910400}}</ref> | ||
==Psychoplastogen== | ===Psychoplastogen=== | ||
Psilocybin is a [[psychoplastogen]],<ref>{{cite journal |last1=Vargas |first1=MV |last2=Meyer |first2=R |last3=Avanes |first3=AA |last4=Rus |first4=M |last5=Olson |first5=DE |title=Psychedelics and Other Psychoplastogens for Treating Mental Illness. |journal=Frontiers in psychiatry |date=2021 |volume=12 |pages=727117 |doi=10.3389/fpsyt.2021.727117 |pmid=34671279 |pmc=8520991}}</ref> which refers to a compound capable of promoting rapid and sustained neuroplasticity. | Psilocybin is a [[psychoplastogen]],<ref>{{cite journal |last1=Vargas |first1=MV |last2=Meyer |first2=R |last3=Avanes |first3=AA |last4=Rus |first4=M |last5=Olson |first5=DE |title=Psychedelics and Other Psychoplastogens for Treating Mental Illness. |journal=Frontiers in psychiatry |date=2021 |volume=12 |pages=727117 |doi=10.3389/fpsyt.2021.727117 |pmid=34671279 |pmc=8520991}}</ref> which refers to a compound capable of promoting rapid and sustained neuroplasticity. | ||