5F-AKB48: Difference between revisions

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==Pharmacology==

Although this substance has not been formally studied from analysis of the structure, it is presumed that AB-FUBINACA has a similar binding profile to that of other [[cannibanoids]] and matches many of the in vivo properties of [[Δ9-THC]]. As with the compounds within [[cannabis]], AB-FUBINACA exhibits its range of effects via full [[agonism]] of both the [[Cannabinoid#Cannabinoid_receptor_type_1|CB1]] and [[Cannabinoid#Cannabinoid_receptor_type_2|CB2]] [[cannabinoid]] [[receptors]], with some selectivity for CB2.

==Subjective effects==

The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[PsychonautWiki#Contributors|contributors]]. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

===Physical effects===

*'''[[Spontaneous tactile sensations|Spontaneous tactile sensations]]''' - The body high of AB-FUBINACA can be described as a warm and soft pleasurable, all-encompassing tingling sensation that spreads over the body prior to initial ingestion. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating.

*'''[[Sedation|Sedation]]''' - Generally, the effects on the user's energy levels are primarily sedating. This encourages one to relax, and at higher doses fall asleep. This can however be suppressed by simply forcing oneself to engage in physical activities.

*'''[[Motor control loss|Motor control loss]]''' - This substance causes a partial to moderate suppression of motor control which intensifies proportional to dosage but rarely results in a complete inability to walk and perform basic movements.

*'''[[Appetite stimulation|Appetite stimulation]]''' - As with many other cannabinoids, AB-FUBINACA causes an increase in appetite<ref>Mechoulam, R. (1984). Cannabinoids as therapeutic agents. Boca Raton, FL: CRC Press. ISBN 0-8493-5772-1.</ref>, known colloquially as "the munchies" in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food.<ref>How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm</ref> This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptor that are responsible for maintaining food intake.<ref>How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm</ref>

*'''[[Dehydration|Dehydration]]'''

*'''[[Vasodilation|Vasodilation]]'''

*'''[[Pain relief|Pain relief]]''' - Cannabinoids have been clinically demonstrated to provide pain relief via agonism of cannabinoid receptors CB<sub>1</sub> and CB<sub>2</sub>, which extends to synthetic cannabinoid receptor agonists. <ref>http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4637.2009.00703.x/abstract</ref><ref>Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2011.03970.x/abstract</ref>

*'''[[Increased bodily weight|Increased bodily weight]]''' ''or'' '''[[Decreased bodily weight|Decreased bodily weight]]'''

*'''[[Changes in gravity|Changes in gravity]]'''

===Cognitive effects===

*'''[[Current mind state enhancement|Current mind state enhancement]]'''

*'''[[Thought connectivity|Thought connectivity]]'''

*'''[[Thought deceleration|Thought deceleration]]'''

*'''[[Conceptual thinking|Conceptual thinking]]'''

*'''[[Mindfulness|Mindfulness]]'''

*'''[[Information processing suppression|Information processing suppression]]'''

*'''[[Dream suppression|Dream suppression]]'''

*'''[[Anxiety|Anxiety]]'''

*'''[[Paranoia|Paranoia]]'''

===Auditory effects===

*'''[[Auditory enhancement|Enhancements]]'''

==Toxicity and Harm Potential==

===Lethal dosage===

@@ Line 4: / Line 4: @@
 ==Pharmacology==
+Although this substance has not been formally studied from analysis of the structure, it is presumed that AB-FUBINACA has a similar binding profile to that of other [[cannibanoids]] and matches many of the in vivo properties of [[Δ9-THC]]. As with the compounds within [[cannabis]], AB-FUBINACA exhibits its range of effects via full [[agonism]] of both the [[Cannabinoid#Cannabinoid_receptor_type_1|CB1]] and [[Cannabinoid#Cannabinoid_receptor_type_2|CB2]] [[cannabinoid]] [[receptors]], with some selectivity for CB2.
 ==Subjective effects==
+{{EffectStub}}
+The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[PsychonautWiki#Contributors|contributors]]. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.
+===Physical effects===
+*'''[[Spontaneous tactile sensations|Spontaneous tactile sensations]]''' - The body high of AB-FUBINACA can be described as a warm and soft pleasurable, all-encompassing tingling sensation that spreads over the body prior to initial ingestion. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating.
+*'''[[Sedation|Sedation]]''' - Generally, the effects on the user's energy levels are primarily sedating. This encourages one to relax, and at higher doses fall asleep. This can however be suppressed by simply forcing oneself to engage in physical activities.
+*'''[[Motor control loss|Motor control loss]]''' - This substance causes a partial to moderate suppression of motor control which intensifies proportional to dosage but rarely results in a complete inability to walk and perform basic movements.
+*'''[[Appetite stimulation|Appetite stimulation]]''' - As with many other cannabinoids, AB-FUBINACA causes an increase in appetite<ref>Mechoulam, R. (1984). Cannabinoids as therapeutic agents. Boca Raton, FL: CRC Press. ISBN 0-8493-5772-1.</ref>, known colloquially as "the munchies" in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food.<ref>How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm</ref> This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptor that are responsible for maintaining food intake.<ref>How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm</ref>
+*'''[[Dehydration|Dehydration]]'''
+*'''[[Vasodilation|Vasodilation]]'''
+*'''[[Pain relief|Pain relief]]''' - Cannabinoids have been clinically demonstrated to provide pain relief via agonism of cannabinoid receptors CB<sub>1</sub> and CB<sub>2</sub>, which extends to synthetic cannabinoid receptor agonists. <ref>http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4637.2009.00703.x/abstract</ref><ref>Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2011.03970.x/abstract</ref>
+*'''[[Increased bodily weight|Increased bodily weight]]''' ''or'' '''[[Decreased bodily weight|Decreased bodily weight]]'''
+*'''[[Changes in gravity|Changes in gravity]]'''
+===Cognitive effects===
+*'''[[Current mind state enhancement|Current mind state enhancement]]'''
+*'''[[Thought connectivity|Thought connectivity]]'''
+*'''[[Thought deceleration|Thought deceleration]]'''
+*'''[[Conceptual thinking|Conceptual thinking]]'''
+*'''[[Mindfulness|Mindfulness]]'''
+*'''[[Information processing suppression|Information processing suppression]]'''
+*'''[[Dream suppression|Dream suppression]]'''
+*'''[[Anxiety|Anxiety]]'''
+*'''[[Paranoia|Paranoia]]'''
+===Auditory effects===
+*'''[[Auditory enhancement|Enhancements]]'''
 ==Toxicity and Harm Potential==
 ===Lethal dosage===