Talk:Aripiprazole: Difference between revisions

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~~Aripiprazole (Abilify)~~

Aripiprazole is a atypical antipsychotic~~. It works by modulating serotonin~~ and ~~dopamine levels in the brain~~. ~~<br />~~

'''Aripiprazole''' (branded as '''Abilify''', '''Aristada''' among others) is an atypical [[psychoactive class::antipsychotic]] approved for the treatment of schizophrenia, psychosis, bipolar disorder, and along with an antidepressant to treat major depressive disorder.

~~hello please make this page~~

Aripiprazole was developed by "Ostuka-group" from Japan as an improvement from first-generation antipsychotics. The active molecule was originally found by the US based Bristol-Myers Squibb.

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===Schizophrenia===

The 2016 [[NICE]] guidance for treating psychosis and schizophrenia in children and young people recommended aripiprazole as a second line treatment after [[risperidone]] for people between 15 and 17 who are having an acute exacerbation or recurrence of psychosis or schizophrenia.<ref>{{cite web |title=Psychosis and schizophrenia in children and young people: recognition and management {{!}} Guidance and guidelines {{!}} NICE |url=https://www.nice.org.uk/guidance/cg155/chapter/Recommendations |publisher=NICE |date=October 2016}}</ref> A 2014 NICE review of the depot formulation of the drug found that it might have a role in treatment as an alternative to other depot formulations of second generation antipsychotics for people who have trouble taking medication as directed or who prefer it.<ref>{{cite web |title=Schizophrenia: aripiprazole prolonged-release suspension for injection {{!}} Guidance and guidelines {{!}} NICE |url=https://www.nice.org.uk/advice/esnm39/chapter/Key-points-from-the-evidence |publisher=NICE |date=24 July 2013}}</ref>

==Adverse effects==

In adults, side effects with greater than 10% incidence include weight gain, headache, [[akathisia]], insomnia, and gastro-intestinal effects like nausea and constipation, and lightheadedness.<ref name = DM/><ref name = EMC/><ref name = EMA/><ref name = ABILIFY/><ref name="WebMD"/> Side effects in children are similar, and include sleepiness, increased appetite, and stuffy nose.<ref name = ABILIFY/> A strong desire to gamble, binge eat, shop, and engage in sexual activity may also occur.<ref name="FDA impulse control">{{cite web |date=3 May 2016 |title=Aripiprazole (Abilify, Abilify Maintena, Aristada): Drug Safety Communication - FDA Warns About New Impulse-control Problems |url=https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-warns-about-new-impulse-control-problems-associated-mental-health |access-date=4 May 2016 |website=U.S. [[Food and Drug Administration]] (FDA)}}</ref><ref name="pmid26658263">{{cite journal | vauthors = Grall-Bronnec M, Sauvaget A, Perrouin F, Leboucher J, Etcheverrigaray F, Challet-Bouju G, Gaboriau L, Derkinderen P, Jolliet P, Victorri-Vigneau C | display-authors = 6 | title = Pathological Gambling Associated With Aripiprazole or Dopamine Replacement Therapy: Do Patients Share the Same Features? A Review | journal = Journal of Clinical Psychopharmacology | volume = 36 | issue = 1 | pages = 63–70 | date = February 2016 | pmid = 26658263 | pmc = 4700874 | doi = 10.1097/JCP.0000000000000444 }}</ref>

Uncontrolled movement such as restlessness, tremors, and muscle stiffness may occur.<ref name = ABILIFY/>

There seems to be no recreational ways for using aripiprazole.

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-Aripiprazole (Abilify)
-Aripiprazole is a atypical antipsychotic. It works by modulating serotonin and dopamine levels in the brain. <br />
+{{SummarySheet}}
+{{SubstanceBox/Aripiprazole}}
+'''Aripiprazole''' (branded as '''Abilify''', '''Aristada''' among others) is an atypical [[psychoactive class::antipsychotic]] approved for the treatment of schizophrenia, psychosis, bipolar disorder, and along with an antidepressant to treat major depressive disorder.
-hello please make this page
+Aripiprazole was developed by "Ostuka-group" from Japan as an improvement from first-generation antipsychotics. The active molecule was originally found by the US based Bristol-Myers Squibb.
-<br />
+===Schizophrenia===
+The 2016 [[NICE]] guidance for treating psychosis and schizophrenia in children and young people recommended aripiprazole as a second line treatment after [[risperidone]] for people between 15 and 17 who are having an acute exacerbation or recurrence of psychosis or schizophrenia.<ref>{{cite web |title=Psychosis and schizophrenia in children and young people: recognition and management {{!}} Guidance and guidelines {{!}} NICE |url=https://www.nice.org.uk/guidance/cg155/chapter/Recommendations |publisher=NICE |date=October 2016}}</ref> A 2014 NICE review of the depot formulation of the drug found that it might have a role in treatment as an alternative to other depot formulations of second generation antipsychotics for people who have trouble taking medication as directed or who prefer it.<ref>{{cite web |title=Schizophrenia: aripiprazole prolonged-release suspension for injection {{!}} Guidance and guidelines {{!}} NICE |url=https://www.nice.org.uk/advice/esnm39/chapter/Key-points-from-the-evidence |publisher=NICE |date=24 July 2013}}</ref>
+==Adverse effects==
+{{See also|List of adverse effects of aripiprazole}}
+In adults, side effects with greater than 10% incidence include weight gain, headache, [[akathisia]], insomnia, and gastro-intestinal effects like nausea and constipation, and lightheadedness.<ref name = DM/><ref name = EMC/><ref name = EMA/><ref name = ABILIFY/><ref name="WebMD"/> Side effects in children are similar, and include sleepiness, increased appetite, and stuffy nose.<ref name = ABILIFY/> A strong desire to gamble, binge eat, shop, and engage in sexual activity may also occur.<ref name="FDA impulse control">{{cite web |date=3 May 2016 |title=Aripiprazole (Abilify, Abilify Maintena, Aristada): Drug Safety Communication - FDA Warns About New Impulse-control Problems |url=https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-warns-about-new-impulse-control-problems-associated-mental-health |access-date=4 May 2016 |website=U.S. [[Food and Drug Administration]] (FDA)}}</ref><ref name="pmid26658263">{{cite journal | vauthors = Grall-Bronnec M, Sauvaget A, Perrouin F, Leboucher J, Etcheverrigaray F, Challet-Bouju G, Gaboriau L, Derkinderen P, Jolliet P, Victorri-Vigneau C | display-authors = 6 | title = Pathological Gambling Associated With Aripiprazole or Dopamine Replacement Therapy: Do Patients Share the Same Features? A Review | journal = Journal of Clinical Psychopharmacology | volume = 36 | issue = 1 | pages = 63–70 | date = February 2016 | pmid = 26658263 | pmc = 4700874 | doi = 10.1097/JCP.0000000000000444 }}</ref>
+Uncontrolled movement such as restlessness, tremors, and muscle stiffness may occur.<ref name = ABILIFY/>
+There seems to be no recreational ways for using aripiprazole.