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Peganum harmala: Difference between revisions
>David Hedlund →Chemistry: Merged the table to {{Peganum harmala alkaloids}} which is now also used by Harmala_alkaloid#Peganum_harmala_.28Syrian_rue.29 |
>Jacubensy Nothing that I have found indicates that harmalas are MAOIs. All recent literature says they are infact RIMAs, and the rest of the paragraph would seem to agree with that. Changing this from "MAOI" to "RIMA" makes the whole paragraph sit in agreement, and I believe is more accurate. |
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[[File:Syrianrueseeds.jpg|150px|thumbnail|left|Syrian rue seeds]] | [[File:Syrianrueseeds.jpg|150px|thumbnail|left|Syrian rue seeds]] | ||
Powdered syrian rue seeds act as a | Powdered syrian rue seeds act as a RIMA at doses of 2-5g. | ||
Syrian rue seeds contain several different harmala alkaloids at slightly varying percentages. Only some are monoamine oxidase A inhibitors. In one study, total harmala alkaloids were at least 5.9% of dried weight.<ref>http://www.phcogrev.com/article.asp?issn=0973-7847;year=2013;volume=7;issue=14;spage=199;epage=212;aulast=Moloudizargari</ref><ref>http://www.tandfonline.com/doi/abs/10.1080/15563650701323205</ref><ref name=partial/> Seed extracts were potent reversible and competitive inhibitors of MAO-A but poor inhibitors of MAO-B.<ref name="new1" /> | Syrian rue seeds contain several different harmala alkaloids at slightly varying percentages. Only some are monoamine oxidase A inhibitors. In one study, total harmala alkaloids were at least 5.9% of dried weight.<ref>http://www.phcogrev.com/article.asp?issn=0973-7847;year=2013;volume=7;issue=14;spage=199;epage=212;aulast=Moloudizargari</ref><ref>http://www.tandfonline.com/doi/abs/10.1080/15563650701323205</ref><ref name="partial" /> Seed extracts were potent reversible and competitive inhibitors of MAO-A but poor inhibitors of MAO-B.<ref name="new1" /> | ||
Total harmala alkaloids were at least 5.9% of dried weight, in one study.<ref name=partial/> | Total harmala alkaloids were at least 5.9% of dried weight, in one study.<ref name="partial" /> | ||
{{Peganum harmala alkaloids}} | {{Peganum harmala alkaloids}} | ||
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====Cholinergics==== | ====Cholinergics==== | ||
[[Cholinergic]] substances combined with ''Peganum harmala'' can cause a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis] because the plant contains several acetylcholinesterase inhibitors (AChEIs): | [[Cholinergic]] substances combined with ''Peganum harmala'' can cause a [https://en.wikipedia.org/wiki/Cholinergic_crisis cholinergic crisis] because the plant contains several acetylcholinesterase inhibitors (AChEIs): | ||
* Desoxypeganine<ref>Studies in Natural Products Chemistry, Volume 43, page 43</ref> | |||
* Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref> | *Desoxypeganine<ref>Studies in Natural Products Chemistry, Volume 43, page 43</ref> | ||
* Harmine<ref name="Pubmed-19784581" /> | *Harmaline<ref name="Pubmed-19784581">https://www.ncbi.nlm.nih.gov/pubmed/19784581</ref> | ||
* Harmol<ref name="Pubmed-19784581" /> | *Harmine<ref name="Pubmed-19784581" /> | ||
* Vasicine (possible)<ref>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122366</ref> | *Harmol<ref name="Pubmed-19784581" /> | ||
*Vasicine (possible)<ref>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122366</ref> | |||
====Drug use in pregnancy==== | ====Drug use in pregnancy==== | ||
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==See also== | ==See also== | ||
*[[Harmala alkaloids]] | *[[Harmala alkaloids]] | ||
*[[Soma (Haoma)]] | *[[Soma (Haoma)]] | ||
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==External links== | ==External links== | ||
*[[wikipedia:Peganum harmala|''Peganum harmala'' (Wikipedia)]] | *[[wikipedia:Peganum harmala|''Peganum harmala'' (Wikipedia)]] | ||
*[https://erowid.org/plants/syrian_rue/syrian_rue.shtml Syrian rue (Erowid)] | *[https://erowid.org/plants/syrian_rue/syrian_rue.shtml Syrian rue (Erowid)] | ||
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==References== | ==References== | ||
<references/> | <references /> | ||
[[Category:Plant]] | [[Category:Plant]] | ||