Myristicin: Difference between revisions

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==Pharmacology==
==Pharmacology==
{{pharmacology}}
In 1963, [[Alexander Shulgin]] speculated myristicin could be metabolized to [[MMDA]], a psychoactive drug related to [[MDA]], in the liver.<ref>http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1966-01-01_4_page003.html</ref> This, however, is unlikely due to the fact that no [[amphetamine]] metabolites were found in urine after the ingestion of myristicin.<ref>https://www.scopus.com/record/display.uri?eid=2-s2.0-33746309901&origin=inward&txGid=1371ffb081f561831f7dc88c134165eb</ref> It is believed that myristicin is an [[deliriant|anticholinergic]], since, in overdose, it produces effects similar to anticholinergics<ref>McKenna, A., Nordt, S. P., & Ryan, J. (2004). Acute nutmeg poisoning. European Journal of Emergency Medicine, 11(4), 240-241. https://doi.org/10.1097/01.mej.0000127649.69328.a5</ref><ref>Abernethy, M. K., & Becker, L. B. (1992). Acute nutmeg intoxication. The American journal of emergency medicine, 10(5), 429-430. https://doi.org/10.1016/0735-6757(92)90069-A</ref>, but the exact mechanism of action has not been established. Myristicin is also found to be a [[serotonin]] [[receptor]] [[antagonist]], while simultaneously acting as a weak [[MAO inhibitor]].{{citation needed}}
In 1963, [[Alexander Shulgin]] speculated myristicin could be metabolized to [[MMDA]], a psychoactive drug related to [[MDA]], in the liver.<ref>http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1966-01-01_4_page003.html</ref> This, however, is unlikely due to the fact that no [[amphetamine]] metabolites were found in urine after the ingestion of myristicin.<ref>https://www.scopus.com/record/display.uri?eid=2-s2.0-33746309901&origin=inward&txGid=1371ffb081f561831f7dc88c134165eb</ref> It is believed that myristicin is an [[deliriant|anticholinergic]], since, in overdose, it produces effects similar to anticholinergics<ref>McKenna, A., Nordt, S. P., & Ryan, J. (2004). Acute nutmeg poisoning. European Journal of Emergency Medicine, 11(4), 240-241. https://doi.org/10.1097/01.mej.0000127649.69328.a5</ref><ref>Abernethy, M. K., & Becker, L. B. (1992). Acute nutmeg intoxication. The American journal of emergency medicine, 10(5), 429-430. https://doi.org/10.1016/0735-6757(92)90069-A</ref>, but the exact mechanism of action has not been established. Myristicin is also found to be a [[serotonin]] [[receptor]] [[antagonist]], while simultaneously acting as a weak [[MAO inhibitor]].{{citation needed}}