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Myristicin: Difference between revisions
>MeyveliPasta Very rare / uncommon and combination effects are removed and other small changes. |
>F3lix.420 Added more information about its pharmacology and tolerance information |
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====Elemicin==== | ====Elemicin==== | ||
Elemicin is found in nutmeg alongside myristicin and contributes to its [[hallucinogenic]] effects. Elemicin is likely to have similar effects to myristicin. It is also the traditional precursor in synthesizing the alkaloid [[mescaline]].{{citation needed}} | Elemicin is found in nutmeg alongside myristicin and contributes to its [[hallucinogenic]] effects. Elemicin is likely to have similar effects to myristicin. It is also the traditional precursor in synthesizing the alkaloid [[mescaline]].{{citation needed}} | ||
==== Cannabinoids ==== | |||
Three compounds in nutmeg (Malabaricone C, Licarin A, 5-Methoxylicarin A) have been proven to act as endo-cannabinoid enhancing agents by inhibiting the enzyme FAAH which is responsible for the breakdown of the endocannabinoid Anandamide. <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938946/</ref>The decrease in the activity of FAAH causes a significant increase in Anandamide levels. This leads to increased CB1 receptor activity which causes cannabimimetic effects, and is believed to be the main cause behind the nutmeg high. | |||
==Subjective effects== | ==Subjective effects== | ||
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===Dependence and abuse potential=== | ===Dependence and abuse potential=== | ||
Although there hasn't been any studies confirming this, nutmeg has been reported by some users to cause mild psychological dependence, similarly to cannabis but to a lesser degree. | |||
Although there have not been any scientific studies on nutmeg tolerance, it has been reported to exhibit cross-tolerance with cannabis, as well as other cannabinoids. | |||
===Dangerous Interactions=== | ===Dangerous Interactions=== | ||
{{DangerousInteractions/Intro}} | {{DangerousInteractions/Intro}} | ||
*'''[[UnsafeInteraction::Stimulants]]''' - Nutmeg puts a fair amount of strain on the cardiovascular system, adding stimulant drugs to the mix would increase side effects. | *'''[[UnsafeInteraction::Stimulants]]''' - Nutmeg puts a fair amount of strain on the cardiovascular system, adding stimulant drugs to the mix would increase side effects. | ||
*'''[[UnsafeInteraction::Alcohol|Alcohol]]''' - Anecdotal reports suggest that small/medium amounts of alcohol can create some positive effects, however respiratory depression is a risk. Large amounts of alcohol should not be combined with myristicin in any circumstance. | *'''[[UnsafeInteraction::Alcohol|Alcohol]]''' - Anecdotal reports suggest that small/medium amounts of alcohol can create some positive effects, however respiratory depression is a risk. Large amounts of alcohol should not be combined with myristicin in any circumstance. | ||
*'''[[DangerousInteraction::Opioids]]''' - Large amounts of opioids can lead to respiratory depression when taken with myristicin. | *'''[[DangerousInteraction::Opioids]]''' - Large amounts of opioids can lead to respiratory depression when taken with myristicin. | ||