PsychonautWiki Archive

List of polysubstance combinations: Difference between revisions

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Poly drug use refers to the use of two or more psychoactive drugs in combination to achieve a particular effect. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.
Poly drug use refers to the use of two or more psychoactive drugs in combination to achieve a particular effect. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.
When combining euphoric stimulants and depressants, such as amphetamines and opioids, the sedative and stimulant effects may cancel out, allowing a higher dose of depressants. If the stimulant's effect wears off first, the user may be overwhelmed by depressant effects such as respiratory depression. These "speed-ball" combinations are also significantly more risky and addictive than either substance alone.<ref>"Speedballs often give stronger effects than either drug when taken alone due to drug synergy, and are a particularly hazardous mixture that can easily cause heart attack, respiratory arrest and death. When compared to single drugs, speedballs are more likely to lead to addiction, and users are more likely to relapse and also to overdose."
https://en.wikipedia.org/wiki/Speedball_(drug)</ref>


A study among treatment admissions found that it is more common for younger people to report polydrug drug use.<ref>"Polydrug Use Among Treatment Admissions: 1998." OAS Home: Alcohol, Tobacco & Drug Abuse and Mental Health Data from SAMHSA, Office of Applied Studies. Web. 29 Sept. 2011. [http://oas.samhsa.gov/2k1/polydrugTX/polydrugTX.htm]</ref>
A study among treatment admissions found that it is more common for younger people to report polydrug drug use.<ref>"Polydrug Use Among Treatment Admissions: 1998." OAS Home: Alcohol, Tobacco & Drug Abuse and Mental Health Data from SAMHSA, Office of Applied Studies. Web. 29 Sept. 2011. [http://oas.samhsa.gov/2k1/polydrugTX/polydrugTX.htm]</ref>
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|'''Any''' drug||[[Nicotine]]|| ||Cooler|| ||A cigarette laced with a drug
|'''Any''' drug||[[Nicotine]]|| ||Cooler|| ||A cigarette laced with a drug
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|'''Any''' [[depressant]]||Any [[stimulant]]|| ||Over and under|| ||
|'''Any''' [[depressant]]||Any [[stimulant]]|| ||Over and under|| ||Depressant effects are often used to gauge intoxication, causing one to overintoxicate themselves. If the stimulant effects wear off first, respiratory depression may occur.
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|'''Any''' [[pharmaceutical]]||Any [[pharmaceutical]]|| ||[https://en.wikipedia.org/wiki/Polypharmacy Polypharmacy]. Pharming|| ||
|'''Any''' [[pharmaceutical]]||Any [[pharmaceutical]]|| ||[https://en.wikipedia.org/wiki/Polypharmacy Polypharmacy]. Pharming, Pharm-hopping|| ||
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|'''Any''' synthetic [[opioid]]||Any opioid|| ||[https://en.wikipedia.org/wiki/Gray_death Gray death]|| ||
|'''Any''' synthetic [[opioid]]||Any opioid|| ||[https://en.wikipedia.org/wiki/Gray_death Gray death]|| ||
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|[[8-chlorotheophylline]]||[[Diphenhydramine]]|| ||Nonproprietary name: [[Dimenhydrinate]]. Street slang: drama, dime" dime tabs, D-Q, substance D, d-house, and drams.<ref>{{Cite web|url=http://www.brighthub.com/science/medical/articles/51711.aspx|title=The Dangers of Dimenhydrinate Abuse|website=Bright Hub|access-date=2016-09-13}}</ref>||Dramatizing or "going a dime a dozen", a reference to the amount of Dramamine tablets generally necessary for a trip.<ref>{{Cite web|url=https://forum.grasscity.com/threads/dramamine.490953/|title=Dramamine|last=|first=|date=|website=Grasscity forums|publisher=|access-date=2016-09-13}}</ref>||
|[[8-chlorotheophylline]]||[[Diphenhydramine]]|| ||Nonproprietary name: [[Dimenhydrinate]]. Street slang: drama, dime" dime tabs, D-Q, substance D, d-house, and drams.<ref>{{Cite web|url=http://www.brighthub.com/science/medical/articles/51711.aspx|title=The Dangers of Dimenhydrinate Abuse|website=Bright Hub|access-date=2016-09-13}}</ref>||Dramatizing or "going a dime a dozen", a reference to the amount of Dramamine tablets generally necessary for a trip.<ref>{{Cite web|url=https://forum.grasscity.com/threads/dramamine.490953/|title=Dramamine|last=|first=|date=|website=Grasscity forums|publisher=|access-date=2016-09-13}}</ref>||
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|[[Alcohol]]||[[Caffeine]]|| ||[https://en.wikipedia.org/wiki/Caffeinated_alcoholic_drink Caffeinated alcoholic drink]|| ||
|[[Alcohol]]||[[Caffeine]]|| ||[https://en.wikipedia.org/wiki/Caffeinated_alcoholic_drink Caffeinated alcoholic drink]|| ||Caffeine, a stimulant, masks some of the [[depressant]] effects of alcohol, may cause overintoxication.
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|[[Alcohol]]||[[Cannabis]]|| ||Herb and Al||Cross fading||
|[[Alcohol]]||[[Cannabis]]|| ||Herb and Al||Cross fading||
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|[[Amphetamine]]||[[Cocaine]]|| ||Snow seals|| ||
|[[Amphetamine]]||[[Cocaine]]|| ||Snow seals|| ||
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|[[Amphetamine]]
|[[Ketamine]]
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|Ketamphetamine
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|May increase blood pressure
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|''Banisteriopsis caapi''||[[Beta-Carboline|β-Carboline]]s containing plants (eg ''Peagnum harmala'')|| ||[[Ayahuasca]], [[changa]]|| ||
|''Banisteriopsis caapi''||[[Beta-Carboline|β-Carboline]]s containing plants (eg ''Peagnum harmala'')|| ||[[Ayahuasca]], [[changa]]|| ||
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|[[Caffeine]]||[[Cannabis]]|| ||Hippie-speedballing|| ||
|[[Caffeine]]||[[Cannabis]]|| ||Hippie-speedballing|| ||
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|[[Caffeine]]||[[Methamphetamine]]|| ||Biker's coffee, [https://en.wikipedia.org/wiki/Ya_ba Ya ba]|| ||
|[[Caffeine]]||[[Methamphetamine]]|| ||Biker's coffee, [https://en.wikipedia.org/wiki/Ya_ba Ya ba]|| ||Generally unnecessary and may increase strain on the heart, anxiety and physical discomfort.
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|[[Cannabis]]||[[Crack-cocaine]]|| ||Crack weed (less known: champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, splitting, thirty eight, turbo, wollie, yeola)||Cocoa puffs<ref>https://www.urbandictionary.com/define.php?term=cocoa+puffs</ref>||
|[[Cannabis]]||[[Crack-cocaine]]|| ||Crack weed (less known: champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, splitting, thirty eight, turbo, wollie, yeola)||Cocoa puffs<ref>https://www.urbandictionary.com/define.php?term=cocoa+puffs</ref>||
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|[[Cocaine]]||[[Heroin]] or [[morphine]]|| ||[https://en.wikipedia.org/wiki/Speedball_(drug) Speedball], powerball||Speedballing, powerballing||Speedballing, powerballing is often used to describe intravenous use. The term can also be applied to use of pharmaceutical opioids, benzodiazepines or barbiturates along with stimulants.
|[[Cocaine]]||[[Heroin]] or [[morphine]]|| ||[https://en.wikipedia.org/wiki/Speedball_(drug) Speedball], powerball||Speedballing, powerballing||Speedballing, powerballing is often used to describe intravenous use. The term can also be applied to use of pharmaceutical opioids, benzodiazepines or barbiturates along with stimulants.
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|[[Cocaine]]||[[Ketamine]]|| ||CK1|| ||
|[[Cocaine]]||[[Ketamine]]|| ||CK, Calvin Klein, Pony Snow|| ||
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|[[Cocaine]]||[[LSD]]|| ||Cracid (or outer limits)|| ||
|[[Cocaine]]||[[LSD]]|| ||Cracid (or outer limits)|| ||
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|[[Crack-cocaine]]||[[Nicotine]]|| ||Coolie, crimmie, woolas|| ||A cigarette laced with crack
|[[Crack-cocaine]]||[[Nicotine]]|| ||Coolie, crimmie, woolas|| ||A cigarette laced with crack
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|[[DMT]]||[[MAOIs]]|| ||[[Pharmahuasca]]|| ||
|[[DMT]]||[[MAOIs]]|| ||[[Ayahuasca]], [[Pharmahuasca]]|| ||Ayahuasca is brewed using natural plant matter.
 
Pharmahuasca is a more pharmaceutical-style preparation of the psychoactive ingredients
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|[[DXM]]||[[LSD]]|| ||LSDXM|| ||
|[[DXM]]||[[LSD]]|| ||LSDXM|| ||
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|[[LSD]]||[[Psilocybin]] or [[psilocybin mushroom]]|| ||God's flesh|| ||
|[[LSD]]||[[Psilocybin]] or [[psilocybin mushroom]]|| ||God's flesh|| ||
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|[[LSD]]||[[MDMA]]||[[2C-B]]|| Ali Flip ||Ali Flipping|| Ali Flipping is a mix of a Candy Flip and a Nexus Flip.
|[[LSD]]||[[MDMA]]||[[2C-B]]||Ali Flip||Ali Flipping||Ali Flipping is a mix of a Candy Flip and a Nexus Flip.
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|[[Psilocybin]]||Any MAOI|| ||Psilohuasca|| ||
|[[Psilocybin]]||Any MAOI|| ||Psilohuasca|| ||
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|[[Xylazine]]||[[Fentanyl]]|| ||Tranq|| ||
|[[Xylazine]]||[[Fentanyl]]|| ||Tranq, Tranq-dope, Sleep cut, Zombie|| ||Often associated with medical complications and deaths, provides excessive sedation with little euphoria.
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|[[DXM]]
|[[DXM]]
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|Counter flip
|Counter flip
|Counter flipping
|Counter flipping
|The synergy of this combo is considered to be unique in that it does not simply combine the effects, but creates a unique experience altogether see [[DXM & DPH]]
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