4-HO-MET: Difference between revisions

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===Tolerance and addiction potential===

4-HO-MET is habit forming, and the desire to use it ~~will increase~~ with use. When addiction has developed, cravings and [[Withdrawal effects|withdrawal effects]] may occur if a person suddenly stops their usage. This is confirmed by the pharmacological profile showing a target for NET, the norepinephrine transporter, which is also targeted by [[methylphenidate]] and [[cocaine]]. Withdrawal from NET inhibitors creates a sensation like the insides of one's body is burning. The TAAR-1 neuron is relatively understudied, but research shows this neuron is responsible in part for amphetamine mediated dopamine release.<ref>[https://pubmed.ncbi.nlm.nih.gov/18083911/ Lindemann, Lothar et al. “Trace amine-associated receptor 1 modulates dopaminergic activity.” ''The Journal of pharmacology and experimental therapeutics'' vol. 324,3 (2008): 948-~~56. doi:10~~.~~1124/jpet.107.132647]</ref>~~

4-HO-MET is [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 4-HO-MET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MET all psychedelics will have a reduced effect.

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 ===Tolerance and addiction potential===
--HO-MET is habit forming, and the desire to use it will increase with use.  When addiction has developed, cravings and [[Withdrawal effects|withdrawal effects]] may occur if a person suddenly stops their usage.  This is confirmed by the pharmacological profile showing a target for NET, the norepinephrine transporter, which is also targeted by [[methylphenidate]] and [[cocaine]].  Withdrawal from NET inhibitors creates a sensation like the insides of one's body is burning.  The TAAR-1 neuron is relatively understudied, but research shows this neuron is responsible in part for amphetamine mediated dopamine release.<ref>[https://pubmed.ncbi.nlm.nih.gov/18083911/ Lindemann, Lothar et al. “Trace amine-associated receptor 1 modulates dopaminergic activity.” ''The Journal of pharmacology and experimental therapeutics'' vol. 324,3 (2008): 948-56. doi:10.1124/jpet.107.132647]</ref>
+-HO-MET is [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with use. It is most often self-regulating.
 Tolerance to the effects of 4-HO-MET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MET all psychedelics will have a reduced effect.