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MAOI: Difference between revisions
>Cristobaldelicia m →Selective MAO-A inhibitors: changed "is" to "are" warning was grammatically incorrect |
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===Before MAOI consumption=== | ===Before MAOI consumption=== | ||
*Substances with slow elimination | *Substances with slow elimination | ||
**[[Methamphetamine]]: Because of its slow elimination, low concentrations of Methamphetamine can be detected in urine for up to 7 days after a single oral dose of 30 mg (Valentine et al., 1995) or up to 60 h after a single 15-mg smoked or intravenous dose (Cook et al., 1993).<ref>{{cite journal | vauthors=((Li, L.)), ((Galloway, G. P.)), ((Verotta, D.)), ((Everhart, E. T.)), ((Baggott, M. J.)), ((Coyle, J. R.)), ((Lopez, J. C.)), ((Mendelson, J.)) | journal=The Journal of Pharmacology and Experimental Therapeutics | title=A Method to Quantify Illicit Intake of Drugs from Urine: Methamphetamine | volume=338 | issue=1 | pages=31–36 | date= July 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126645/ | issn=0022-3565 | doi=10.1124/jpet.111.179176}}</ref> A chronic meth user might still test positive seven to 10 days after consuming the drug. | **[[Methamphetamine]]: Because of its slow elimination, low concentrations of Methamphetamine can be detected in urine for up to 7 days after a single oral dose of 30 mg (Valentine et al., 1995) or up to 60 h after a single 15-mg smoked or intravenous dose (Cook et al., 1993).<ref>{{cite journal | vauthors=((Li, L.)), ((Galloway, G. P.)), ((Verotta, D.)), ((Everhart, E. T.)), ((Baggott, M. J.)), ((Coyle, J. R.)), ((Lopez, J. C.)), ((Mendelson, J.)) | journal=The Journal of Pharmacology and Experimental Therapeutics | title=A Method to Quantify Illicit Intake of Drugs from Urine: Methamphetamine | volume=338 | issue=1 | pages=31–36 | date= July 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126645/ | issn=0022-3565 | doi=10.1124/jpet.111.179176}}</ref> A chronic meth user might still test positive seven to 10 days after consuming the drug. | ||
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==Poly drug use== | ==Poly drug use== | ||
*[[Ayahuasca]]: The [[tryptamine]] [[DMT]] will break down without MAOIs when taken orally. | *[[Ayahuasca]]: The [[tryptamine]] [[DMT]] will break down without MAOIs when taken orally. | ||
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===Nonselective MAOIs/RIMAs=== | ===Nonselective MAOIs/RIMAs=== | ||
*Naturally occurring sources | *Naturally occurring sources | ||
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===Selective MAO-B inhibitors=== | ===Selective MAO-B inhibitors=== | ||
*Naturally occurring sources | *Naturally occurring sources | ||
**Kava (''Piper methysticum''): Yangonin. Kava pyrones: The order of potency was desmethoxyyangonin > (+/-)-methysticin > yangonin > (+/-)-dihydromethysticin > (+/-)- dihydrokavain > (+/-)-kavain.<ref>{{cite journal | vauthors=((Uebelhack, R.)), ((Franke, L.)), ((Schewe, H. J.)) | journal=Pharmacopsychiatry | title=Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava) | volume=31 | issue=5 | pages=187–192 | date= September 1998 | issn=0176-3679 | doi=10.1055/s-2007-979325}}</ref> | **Kava (''Piper methysticum''): Yangonin. Kava pyrones: The order of potency was desmethoxyyangonin > (+/-)-methysticin > yangonin > (+/-)-dihydromethysticin > (+/-)- dihydrokavain > (+/-)-kavain.<ref>{{cite journal | vauthors=((Uebelhack, R.)), ((Franke, L.)), ((Schewe, H. J.)) | journal=Pharmacopsychiatry | title=Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava) | volume=31 | issue=5 | pages=187–192 | date= September 1998 | issn=0176-3679 | doi=10.1055/s-2007-979325}}</ref> | ||
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===Unknown selectivity=== | ===Unknown selectivity=== | ||
*Psychedelics | *Psychedelics | ||
**[[5-MeO-AET]] | **[[5-MeO-AET]] | ||
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====By chemicals==== | ====By chemicals==== | ||
*Amino acids, and amino acid metabolism metabolic intermediates | *Amino acids, and amino acid metabolism metabolic intermediates | ||
**Monoamine precursors | **Monoamine precursors | ||
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====By pharmacotherapy==== | ====By pharmacotherapy==== | ||
*Antibiotics | *Antibiotics | ||
**Linezolid | **Linezolid | ||
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===Essential vitamins and minerals=== | ===Essential vitamins and minerals=== | ||
*Vitamin B6: MAOIs may reduce blood levels of vitamin B6. Not studied on harmalas. But on tranylcypromine (a cyclopropane), and phenelzine (a hydrazine), two pharms with distinct chemical groups. | *Vitamin B6: MAOIs may reduce blood levels of vitamin B6. Not studied on harmalas. But on tranylcypromine (a cyclopropane), and phenelzine (a hydrazine), two pharms with distinct chemical groups. | ||
===Substances=== | ===Substances=== | ||
*[[Lysergamides]]: [[LSD]]. MAOIs seem to cause a greater reduction in the effects of LSD than SSRIs.<ref>{{Citation | title=Erowid LSD (Acid) Vault : LSD and Antidepressants, by Mike | url=https://erowid.org/chemicals/lsd/lsd_health3.shtml}}</ref> | *[[Lysergamides]]: [[LSD]]. MAOIs seem to cause a greater reduction in the effects of LSD than SSRIs.<ref>{{Citation | title=Erowid LSD (Acid) Vault : LSD and Antidepressants, by Mike | url=https://erowid.org/chemicals/lsd/lsd_health3.shtml}}</ref> | ||
===Research=== | ===Research=== | ||
*Naturally occurring sources | *Naturally occurring sources | ||
**''[[Mimosa tenuiflora (botany)|Mimosa tenuiflora]]'': As there have been no MAO inhibitors detected in M. tenuiflora, there is ongoing interest into how yurema exerts its visionary effects.<ref>{{Citation | title=Dimethyltryptamine - an overview, ScienceDirect Topics | url=https://www.sciencedirect.com/topics/neuroscience/dimethyltryptamine}}</ref> | **''[[Mimosa tenuiflora (botany)|Mimosa tenuiflora]]'': As there have been no MAO inhibitors detected in M. tenuiflora, there is ongoing interest into how yurema exerts its visionary effects.<ref>{{Citation | title=Dimethyltryptamine - an overview, ScienceDirect Topics | url=https://www.sciencedirect.com/topics/neuroscience/dimethyltryptamine}}</ref> | ||
==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[RIMA]] | *[[RIMA]] | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor Monoamine oxidase inhibitor (Wikipedia)] | *[https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor Monoamine oxidase inhibitor (Wikipedia)] | ||
*[https://en.wikipedia.org/wiki/Monoamine_oxidase_A Monoamine oxidase A (Wikipedia)] | *[https://en.wikipedia.org/wiki/Monoamine_oxidase_A Monoamine oxidase A (Wikipedia)] | ||
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{{#set:Featured=true}} | {{#set:Featured=true}} | ||