Talk:Bromazolam: Difference between revisions

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''Bromazolam''' (also known as '''Brom''' or '''~~Bromaz~~''') is a [[psychoactive class::depressant]] substance of the [[Chemical class::benzodiazepine]] class. Its characteristic effects include [[anxiety suppression]], [[sedation]], [[disinhibition]], and [[muscle relaxation]]. It is currently unscheduled in most parts of the world, and hence it is commonly sold as a research chemical.

''Bromazolam''' (also known as '''Brom''', '''Bromaz''', or '''XLI-268''') is a [[psychoactive class::depressant]] substance of the [[Chemical class::benzodiazepine]] class - more specifically it is a triazolobenzodiazepine (TBZD). Its characteristic effects include [[anxiety suppression]], [[sedation]], [[disinhibition]], and [[muscle relaxation]]. It is currently unscheduled in most parts of the world, and hence it is commonly sold as a research chemical. It is most commonly seen as a slightly more sedating and longer-lasting version of alprazolam

Like other [[benzodiazepines]], bromazolam binds to specific sites on the [[gamma-amino-butyric acid|GABAA]] receptor.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/</ref> Since it is not available by prescription and is sold online on clearnet and darknet vendors - it is commonly used to self-medicate or for recreational purposes

Like other [[benzodiazepines]], bromazolam binds to specific sites on the [[gamma-amino-butyric acid|GABAA]] receptor.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/</ref> Since it is not available by prescription and is sold online on clearnet and darknet vendors - it is commonly used to self-medicate or for recreational purposes.

The [[Benzodiazepine#Discontinuation|sudden discontinuation of benzodiazepines]] can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death.<ref>A fatal case of benzodiazepine withdrawal. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/19465812</ref> It is highly recommended to [[taper]] one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref>

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==History and culture==

Bromazolam was first synthesized in 1976, but was never marketed.[1]

==Chemistry==

It is the bromo instead of chloro analogue of alprazolam and its chemical formula is C17H13BrN4.

==Pharmacology==

Bromazolam is a triazolobenzodiazepine (TBZD) which was first synthesized in 1976, but was never marketed.[1] It has subsequently been sold as a designer drug, first being definitively identified by the EMCDDA in Sweden in 2016.[2] It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic effects to it and other benzodiazepines.[3][4] Bromazolam is a non subtype selective agonist at the benzodiazepine (BZD) site of [[gamma-amino-butyric acid|GABAA]] receptors, with a binding affinity of 2.81nM at the α1 subtype, 0.69nM at α2 and 0.62nM at α5.[5]

==Subjective effects==

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 {{SubstanceBox/Example}}
-''Bromazolam''' (also known as '''Brom''' or '''Bromaz''') is a [[psychoactive class::depressant]] substance of the [[Chemical class::benzodiazepine]] class. Its characteristic effects include [[anxiety suppression]], [[sedation]], [[disinhibition]], and [[muscle relaxation]]. It is currently unscheduled in most parts of the world, and hence it is commonly sold as a research chemical.
+''Bromazolam''' (also known as '''Brom''', '''Bromaz''', or '''XLI-268''') is a [[psychoactive class::depressant]] substance of the [[Chemical class::benzodiazepine]] class - more specifically it is a triazolobenzodiazepine (TBZD). Its characteristic effects include [[anxiety suppression]], [[sedation]], [[disinhibition]], and [[muscle relaxation]]. It is currently unscheduled in most parts of the world, and hence it is commonly sold as a research chemical. It is most commonly seen as a slightly more sedating and longer-lasting version of alprazolam
-Like other [[benzodiazepines]], bromazolam binds to specific sites on the [[gamma-amino-butyric acid|GABA<sub>A</sub>]] receptor.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/</ref> Since it is not available by prescription and is sold online on clearnet and darknet vendors - it is commonly used to self-medicate or for recreational purposes
+Like other [[benzodiazepines]], bromazolam binds to specific sites on the [[gamma-amino-butyric acid|GABA<sub>A</sub>]] receptor.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/</ref> Since it is not available by prescription and is sold online on clearnet and darknet vendors - it is commonly used to self-medicate or for recreational purposes.
 The [[Benzodiazepine#Discontinuation|sudden discontinuation of benzodiazepines]] can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death.<ref>A fatal case of benzodiazepine withdrawal. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/19465812</ref> It is highly recommended to [[taper]] one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref>
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 ==History and culture==
 {{historyStub}}
+Bromazolam was first synthesized in 1976, but was never marketed.[1]
 ==Chemistry==
 {{chemistry}}
+It is the bromo instead of chloro analogue of alprazolam and its chemical formula is C17H13BrN4.
 ==Pharmacology==
 {{pharmacology}}
+Bromazolam is a triazolobenzodiazepine (TBZD) which was first synthesized in 1976, but was never marketed.[1] It has subsequently been sold as a designer drug, first being definitively identified by the EMCDDA in Sweden in 2016.[2] It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic effects to it and other benzodiazepines.[3][4] Bromazolam is a non subtype selective agonist at the benzodiazepine (BZD) site of [[gamma-amino-butyric acid|GABA<sub>A</sub>]]  receptors, with a binding affinity of 2.81nM at the α1 subtype, 0.69nM at α2 and 0.62nM at α5.[5]
 ==Subjective effects==