Talk:N-Methyl-Cyclazodone: Difference between revisions

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Unlike [[cyclazodone]], '''N-methyl-cyclazodone''' has little to no history of use and only recently emerged as a study aid. Its non-clinical use has only found recent attention as a [[research chemical]] study aid or atypical [[antidepressant]]. It should be noted that the lack of pharmacological data and extremely limited history of human usage pose considerable concern regarding its long-term use as a substitute for prescription stimulants or [[antidepressants]]. Similar to [[methamphetamine]], this substance is reported to possess an usually long duration, it is therefore recommended to take one's dose in the morning and avoid redosing.

[[Subjective effects]] include [[stimulation]], [[focus enhancement]], [[stamina enhancement]], [[increased blood pressure]], and mild [[euphoria]]. Some anecdotal reports suggest that '''N-methyl-cyclazodone''' and its parent compound [[cyclazodone]] may have nootropic properties similar to central nervous system stimulants such as [[methylphenidate]] and [[amphetamine]].

One of its parent compounds, [[thozalinone]], has been used as an [[antidepressant]] in europe<ref>{{cite journal | vauthors = Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB | title = A double-blind study of thozalinone (C1 39,808) in depressed outpatients | journal = Current Therapeutic Research, Clinical and Experimental | volume = 8 | issue = 12 | pages = 621–2 | date = December 1966 | pmid = 4962734 }}</ref>, which may be due to its serotonin-releasing properties.

[[Subjective effects]] include [[stimulation]], [[focus enhancement]], [[stamina enhancement]], [[increased blood pressure]], and mild [[euphoria]]. Some anecdotal reports suggest that '''N-methyl-cyclazodone''' and its parent compound [[cyclazodone]] may have nootropic properties similar to central nervous system stimulants such as [[methylphenidate]] and [[amphetamine]].

'''N-methyl-cyclazodone''' has no documented history of recreational human usage before it appeared on the online research chemical market in 2017. Based on related compounds, it is speculated that it likely possesses hepatotoxic and other not-yet-known toxic properties.

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*'''[[Effect::Stamina enhancement]]'''

*'''[[Effect::Abnormal heartbeat]]'''{{citation needed}}

*'''[[Effect::Increased heart rate]]'''{{citation needed}} - ~~Cyclazodone~~ is reported to ~~elevate heart rate to a greater degree than~~ [[~~amphetamine~~]].

*'''[[Effect::Increased heart rate]]'''{{citation needed}} - This effect is reported to be not as strong with N-methyl-cyclazodone as with [[cyclazodone]]

*'''[[Effect::Increased blood pressure]]'''{{citation needed}}

*'''[[Effect::Appetite suppression]]'''

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*'''[[Effect::Pupil dilation]]''' - This effect is typically experienced only at higher dosages and is more prominent on the comedown.

*'''[[Effect::Stomach cramps]]'''

*'''[[Effect::Teeth grinding]]''' - This component is reported to be less intense compared to[[MDMA]], and only prominent when dosing for prolonged periods of time.

*'''[[Effect::Teeth grinding]]''' - This component is reported to be less intense compared to [[MDMA]], and only prominent when dosing for prolonged periods of time.

*'''[[Effect::Temporary erectile dysfunction]]'''

*'''[[Effect::Vasoconstriction]]'''{{citation needed}}

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*'''[[Effect::Delusion]]'''

*'''[[Effect::Disinhibition]]'''

*'''[[Effect::Ego inflation]]''' ~~- Cyclazodone, at moderate doses, has been reported to substantially increase confidence and self-esteem. Higher doses, however, can result in complete self-absorption and ego mania.~~

*'''[[Effect::Ego inflation]]'''

*'''[[Effect::Emotion suppression]]'''

*'''[[Effect::Focus enhancement]]'''

@@ Line 4: / Line 4: @@
 Unlike [[cyclazodone]], '''N-methyl-cyclazodone''' has little to no history of use and only recently emerged as a study aid. Its non-clinical use has only found recent attention as a [[research chemical]] study aid or atypical [[antidepressant]]. It should be noted that the lack of pharmacological data and extremely limited history of human usage pose considerable concern regarding its long-term use as a substitute for prescription stimulants or [[antidepressants]]. Similar to [[methamphetamine]], this substance is reported to possess an usually long duration, it is therefore recommended to take one's dose in the morning and avoid redosing.
+[[Subjective effects]] include [[stimulation]], [[focus enhancement]], [[stamina enhancement]], [[increased blood pressure]], and mild [[euphoria]]. Some anecdotal reports suggest that '''N-methyl-cyclazodone''' and its parent compound [[cyclazodone]] may have nootropic properties similar to central nervous system stimulants such as [[methylphenidate]] and [[amphetamine]].
 One of its parent compounds, [[thozalinone]], has been used as an [[antidepressant]] in europe<ref>{{cite journal | vauthors = Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB | title = A double-blind study of thozalinone (C1 39,808) in depressed outpatients | journal = Current Therapeutic Research, Clinical and Experimental | volume = 8 | issue = 12 | pages = 621–2 | date = December 1966 | pmid = 4962734 }}</ref>, which may be due to its serotonin-releasing properties.
-[[Subjective effects]] include [[stimulation]], [[focus enhancement]], [[stamina enhancement]], [[increased blood pressure]], and mild [[euphoria]]. Some anecdotal reports suggest that '''N-methyl-cyclazodone''' and its parent compound [[cyclazodone]] may have nootropic properties similar to central nervous system stimulants such as [[methylphenidate]] and [[amphetamine]].
 '''N-methyl-cyclazodone''' has no documented history of recreational human usage before it appeared on the online research chemical market in 2017. Based on related compounds, it is speculated that it likely possesses hepatotoxic and other not-yet-known toxic properties.
@@ Line 35: / Line 35: @@
 *'''[[Effect::Stamina enhancement]]'''
 *'''[[Effect::Abnormal heartbeat]]'''{{citation needed}}
-*'''[[Effect::Increased heart rate]]'''{{citation needed}} - Cyclazodone is reported to elevate heart rate to a greater degree than [[amphetamine]].
+*'''[[Effect::Increased heart rate]]'''{{citation needed}} - This effect is reported to be not as strong with N-methyl-cyclazodone as with [[cyclazodone]]
 *'''[[Effect::Increased blood pressure]]'''{{citation needed}}
 *'''[[Effect::Appetite suppression]]'''
@@ Line 48: / Line 48: @@
 *'''[[Effect::Pupil dilation]]''' - This effect is typically experienced only at higher dosages and is more prominent on the comedown.
 *'''[[Effect::Stomach cramps]]'''
-*'''[[Effect::Teeth grinding]]''' - This component is reported to be less intense compared to[[MDMA]], and only prominent when dosing for prolonged periods of time.
+*'''[[Effect::Teeth grinding]]''' - This component is reported to be less intense compared to [[MDMA]], and only prominent when dosing for prolonged periods of time.
 *'''[[Effect::Temporary erectile dysfunction]]'''
 *'''[[Effect::Vasoconstriction]]'''{{citation needed}}
@@ Line 75: / Line 75: @@
 *'''[[Effect::Delusion]]'''
 *'''[[Effect::Disinhibition]]'''
-*'''[[Effect::Ego inflation]]''' - Cyclazodone, at moderate doses, has been reported to substantially increase confidence and self-esteem. Higher doses, however, can result in complete self-absorption and ego mania.
+*'''[[Effect::Ego inflation]]'''
 *'''[[Effect::Emotion suppression]]'''
 *'''[[Effect::Focus enhancement]]'''