Talk:N-Methyl-Cyclazodone: Difference between revisions

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===Pharmacodynamics===

Cyclazodone is an [[amphetamine]]-like [[agonist]] of the Trace Amine Associated Receptor 1 (TAAR1), which is a key regulator of common and trace brain monoamines such as [[dopamine]], [[serotonin]] and [[noradrenaline]].<ref>The Emerging Role of Trace Amine Associated Receptor 1 in the Functional Regulation of Monoamine Transporters and Dopaminergic Activity (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005101/</ref><ref>Drug banks amphetamine targets | http://www.drugbank.ca/drugs/DB00182#targets</ref><ref>TA1 receptor | http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=364</ref> The agonism of this set of receptors results in the release of increased concentrations of [[dopamine]], [[serotonin]] and [[noradrenaline]] in the [[synaptic cleft]]. This leads to [[Thought acceleration|cognitive]] and [[Stimulation|physical stimulation]] within the user.

==Subjective effects==

The ~~stimulant~~ effects of cyclazodone ~~have been~~ compared to those of [[~~amphetamine~~]], but with ~~the addition of a low to moderate affinity for [[~~serotonin~~]] release~~ comparable to that of [[methamphetamine]] and [[3-FMA]]. Additionally, it is noticeably less euphoric than ~~amphetamine~~ and appears to have less sympathomimetic activation.

The effects of N-methyl-cyclazodone could be compared to those of [[cyclazodone]] and [[modafinil]], but with longer duration and potentially more side effects. It also possesses mild serotonin-releasing properties comparable to that of [[methamphetamine]] and [[3-FMA]], which become more prominent at higher doses, as well as greater side effects. Additionally, it is noticeably less euphoric than [[methamphetamine]] and [[3-FMA]] and appears to have less sympathomimetic activation.

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|{{effects/physical|

*'''[[Effect::Stimulation]]''' - ~~Cyclazodone~~ is reported to be somewhat stimulating though soft in a fashion that is ~~slightly~~ weaker to that of [[methamphetamine]], but stronger than that of [[modafinil]], [[caffeine]], and [[methylphenidate]].

*'''[[Effect::Stimulation]]''' - N-methyl-cyclazodone is reported to be somewhat stimulating though soft in a fashion that is generally weaker to that of [[methamphetamine]], but stronger than that of [[modafinil]], [[caffeine]], and [[methylphenidate]].

*'''[[Effect::Physical euphoria]]''' - This effect is dose dependent and tends only to be present at higher doses. ~~Cyclazodone~~ is reported to lack the body glow associated with [[amphetamine]] at typical doses.

*'''[[Effect::Physical euphoria]]''' - This effect is dose dependent and tends only to be present at higher doses. N-methyl-cyclazodone is reported to lack the body glow associated with [[amphetamine]] at typical doses.

*'''[[Effect::Stamina enhancement]]'''

*'''[[Effect::Abnormal heartbeat]]'''{{citation needed}}

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*'''[[Effect::Dry mouth]]'''

*'''[[Effect::Frequent urination]]'''

*'''[[Effect::Headaches]]'''

*'''[[Effect::Increased bodily temperature]]'''

*'''[[Effect::Increased perspiration]]'''

*'''[[Effect::Nausea]]''' - Typically a result of dosing for prolonged periods of time and dehydration.

*'''[[Effect::Pain relief]]'''

*'''[[Effect::Pupil dilation]]''' - This effect is typically experienced only at higher dosages and is more prominent on the comedown.

*'''[[Effect::Stomach cramps]]'''

*'''[[Effect::Teeth grinding]]''' - This component is reported to be less intense compared to[[MDMA]], and only prominent when dosing for prolonged periods of time.

*'''[[Effect::Temporary erectile dysfunction]]'''

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}}

{{effects/visual|

~~The~~ visual effects ~~of cyclazodone are usually less consistent and only mildly noticeable~~ at higher dosages. They ~~may manifest as a brightening of colors and areas of light appearing brighter~~ than ~~that of their surrounding~~.

N-methyl-cyclazodone may produce mild visual effects at higher dosages and in combination with [[Sleep deprivation]] if the user has been awake for long periods of time. They are generally less common than with [[amphetamines]].

====Distortions====

@@ Line 23: / Line 23: @@
 ===Pharmacodynamics===
-Cyclazodone is an [[amphetamine]]-like [[agonist]] of the Trace Amine Associated Receptor 1 (TAAR1), which is a key regulator of common and trace brain monoamines such as [[dopamine]], [[serotonin]] and [[noradrenaline]].<ref>The Emerging Role of Trace Amine Associated Receptor 1 in the Functional Regulation of Monoamine Transporters and Dopaminergic Activity (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005101/</ref><ref>Drug banks amphetamine targets | http://www.drugbank.ca/drugs/DB00182#targets</ref><ref>TA1 receptor | http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=364</ref> The agonism of this set of receptors results in the release of increased concentrations of [[dopamine]], [[serotonin]] and [[noradrenaline]] in the [[synaptic cleft]]. This leads to [[Thought acceleration|cognitive]] and [[Stimulation|physical stimulation]] within the user.
 ==Subjective effects==
-The stimulant effects of cyclazodone have been compared to those of [[amphetamine]], but with the addition of a low to moderate affinity for [[serotonin]] release comparable to that of [[methamphetamine]] and [[3-FMA]]. Additionally, it is noticeably less euphoric than amphetamine and appears to have less sympathomimetic activation.
+The effects of N-methyl-cyclazodone could be compared to those of [[cyclazodone]] and [[modafinil]], but with longer duration and potentially more side effects. It also possesses mild serotonin-releasing properties comparable to that of [[methamphetamine]] and [[3-FMA]], which become more prominent at higher doses, as well as greater side effects. Additionally, it is noticeably less euphoric than [[methamphetamine]] and [[3-FMA]] and appears to have less sympathomimetic activation.
 {{Preamble/SubjectiveEffects}}
@@ Line 32: / Line 31: @@
 |{{effects/physical|
-*'''[[Effect::Stimulation]]''' - Cyclazodone is reported to be somewhat stimulating though soft in a fashion that is slightly weaker to that of [[methamphetamine]], but stronger than that of [[modafinil]], [[caffeine]], and [[methylphenidate]].
+*'''[[Effect::Stimulation]]''' - N-methyl-cyclazodone is reported to be somewhat stimulating though soft in a fashion that is generally weaker to that of [[methamphetamine]], but stronger than that of [[modafinil]], [[caffeine]], and [[methylphenidate]].
-*'''[[Effect::Physical euphoria]]''' - This effect is dose dependent and tends only to be present at higher doses. Cyclazodone is reported to lack the body glow associated with [[amphetamine]] at typical doses.
+*'''[[Effect::Physical euphoria]]''' - This effect is dose dependent and tends only to be present at higher doses. N-methyl-cyclazodone is reported to lack the body glow associated with [[amphetamine]] at typical doses.
 *'''[[Effect::Stamina enhancement]]'''
 *'''[[Effect::Abnormal heartbeat]]'''{{citation needed}}
@@ Line 43: / Line 42: @@
 *'''[[Effect::Dry mouth]]'''
 *'''[[Effect::Frequent urination]]'''
+*'''[[Effect::Headaches]]'''
 *'''[[Effect::Increased bodily temperature]]'''
 *'''[[Effect::Increased perspiration]]'''
 *'''[[Effect::Nausea]]''' - Typically a result of dosing for prolonged periods of time and dehydration.
-*'''[[Effect::Pain relief]]'''
 *'''[[Effect::Pupil dilation]]''' - This effect is typically experienced only at higher dosages and is more prominent on the comedown.
+*'''[[Effect::Stomach cramps]]'''
 *'''[[Effect::Teeth grinding]]''' - This component is reported to be less intense compared to[[MDMA]], and only prominent when dosing for prolonged periods of time.
 *'''[[Effect::Temporary erectile dysfunction]]'''
@@ Line 56: / Line 56: @@
 }}
 {{effects/visual|
-The visual effects of cyclazodone are usually less consistent and only mildly noticeable at higher dosages. They may manifest as a brightening of colors and areas of light appearing brighter than that of their surrounding.
+N-methyl-cyclazodone may produce mild visual effects at higher dosages and in combination with [[Sleep deprivation]] if the user has been awake for long periods of time. They are generally less common than with [[amphetamines]].
 ====Distortions====