1cP-LSD: Difference between revisions - PsychonautWiki Archive

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'''1-Cyclopropionyl-''d''-lysergic acid diethylamide''' (also known as '''1cP-LSD''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of the [[Chemical class::lysergamide]] class. It is ~~chemically similar~~ to [[LSD]] and other LSD analogs like [[1B-LSD]], [[ALD-52]], and [[1P-LSD]]. It is suspected to produce its effects by binding to [[serotonin]] [[receptors]] in the brain; however, its precise mechanism is not known.<ref name="Brandt2020">{{cite journal|title=Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)|first1=Simon D.|last1=Brandt|first2=Pierce V.|last2=Kavanagh|first3=Folker|last3=Westphal|first4=Alexander|last4=Stratford|first5=Anna U.|last5=Odland|first6=Adam K.|last6=Klein|first7=Geraldine|last7=Dowling|first8=Nicola M.|last8=Dempster|first9=Jason|last9=Wallach|first10=Torsten|last10=Passie|first11=Adam L.|last11=Halberstadt|date=March 16, 2020|doi=10.1002/dta.2789|volume=12|issue=6|journal=Drug Testing and Analysis|pages=812-826|eissn=1942-7611|issn=1942-7603|oclc=231680670|pmid=32180350}}</ref>

'''1-Cyclopropionyl-''d''-lysergic acid diethylamide''' (also known as '''1cP-LSD''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of the [[Chemical class::lysergamide]] class. It is structurally related to [[LSD]] and other LSD analogs like [[1B-LSD]], [[ALD-52]], and [[1P-LSD]]. It is suspected to produce its effects by binding to [[serotonin]] [[receptors]] in the brain; however, its precise mechanism is not known.<ref name="Brandt2020">{{cite journal|title=Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)|first1=Simon D.|last1=Brandt|first2=Pierce V.|last2=Kavanagh|first3=Folker|last3=Westphal|first4=Alexander|last4=Stratford|first5=Anna U.|last5=Odland|first6=Adam K.|last6=Klein|first7=Geraldine|last7=Dowling|first8=Nicola M.|last8=Dempster|first9=Jason|last9=Wallach|first10=Torsten|last10=Passie|first11=Adam L.|last11=Halberstadt|date=March 16, 2020|doi=10.1002/dta.2789|volume=12|issue=6|journal=Drug Testing and Analysis|pages=812-826|eissn=1942-7611|issn=1942-7603|oclc=231680670|pmid=32180350}}</ref>

The origins of 1cP-LSD are not well-documented. Following 1P-LSD's prohibition in Germany, 1cP-LSD appeared on the online [[research chemical]] market in 2019.{{citation needed}} Like other LSD analogs, it was marketed as a legal alternative to LSD and 1P-LSD.

[[Subjective effects]] include [[geometry|open and closed eye visuals]], [[time distortion]], [[conceptual thinking]], [[introspection|enhanced introspection]], [[euphoria]], and [[ego loss]]. A study found that incubation of 1cP‐LSD with human serum led to the formation of LSD, indicating that it may act as a [[prodrug]] for LSD.<ref name="Brandt2020"></ref> Anecdotal reports appear to ~~be consistent~~ with this theory, with most users reporting near-identical effects as LSD. It has been reported to have a more gradual come up, along with mildly smoother cognitive and physical effects compared to ~~1P-~~LSD.

[[Subjective effects]] include [[geometry|open and closed eye visuals]], [[time distortion]], [[conceptual thinking]], [[introspection|enhanced introspection]], [[euphoria]], and [[ego loss]]. A study found that incubation of 1cP‐LSD with human serum led to the formation of LSD, indicating that it may act as a [[prodrug]] for LSD.<ref name="Brandt2020"></ref> Anecdotal reports appear to support with this theory, with most users reporting near-identical effects as LSD. It has been reported to have a more gradual come up, along with mildly smoother cognitive and physical effects compared to LSD.

Limited data exist on the pharmacology, metabolism, and toxicity of 1cP-LSD. While it is presumed to have a [[LSD#Toxicity and harm potential|similar risk profile as LSD]] and its analogs, which are generally thought to be safe in controlled settings, reliable scientific data is lacking. It is highly advised to use [[harm reduction practices]] if using this substance.

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 {{SummarySheet}}
 {{SubstanceBox/1cP-LSD}}
-'''1-Cyclopropionyl-''d''-lysergic acid diethylamide''' (also known as '''1cP-LSD''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of the [[Chemical class::lysergamide]] class. It is chemically similar to [[LSD]] and other LSD analogs like [[1B-LSD]], [[ALD-52]], and [[1P-LSD]]. It is suspected to produce its effects by binding to [[serotonin]] [[receptors]] in the brain; however, its precise mechanism is not known.<ref name="Brandt2020">{{cite journal|title=Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)|first1=Simon D.|last1=Brandt|first2=Pierce V.|last2=Kavanagh|first3=Folker|last3=Westphal|first4=Alexander|last4=Stratford|first5=Anna U.|last5=Odland|first6=Adam K.|last6=Klein|first7=Geraldine|last7=Dowling|first8=Nicola M.|last8=Dempster|first9=Jason|last9=Wallach|first10=Torsten|last10=Passie|first11=Adam L.|last11=Halberstadt|date=March 16, 2020|doi=10.1002/dta.2789|volume=12|issue=6|journal=Drug Testing and Analysis|pages=812-826|eissn=1942-7611|issn=1942-7603|oclc=231680670|pmid=32180350}}</ref>
+'''1-Cyclopropionyl-''d''-lysergic acid diethylamide''' (also known as '''1cP-LSD''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of the [[Chemical class::lysergamide]] class. It is structurally related to [[LSD]] and other LSD analogs like [[1B-LSD]], [[ALD-52]], and [[1P-LSD]]. It is suspected to produce its effects by binding to [[serotonin]] [[receptors]] in the brain; however, its precise mechanism is not known.<ref name="Brandt2020">{{cite journal|title=Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)|first1=Simon D.|last1=Brandt|first2=Pierce V.|last2=Kavanagh|first3=Folker|last3=Westphal|first4=Alexander|last4=Stratford|first5=Anna U.|last5=Odland|first6=Adam K.|last6=Klein|first7=Geraldine|last7=Dowling|first8=Nicola M.|last8=Dempster|first9=Jason|last9=Wallach|first10=Torsten|last10=Passie|first11=Adam L.|last11=Halberstadt|date=March 16, 2020|doi=10.1002/dta.2789|volume=12|issue=6|journal=Drug Testing and Analysis|pages=812-826|eissn=1942-7611|issn=1942-7603|oclc=231680670|pmid=32180350}}</ref>
 The origins of 1cP-LSD are not well-documented. Following 1P-LSD's prohibition in Germany, 1cP-LSD appeared on the online [[research chemical]] market in 2019.{{citation needed}} Like other LSD analogs, it was marketed as a legal alternative to LSD and 1P-LSD.
-[[Subjective effects]] include [[geometry|open and closed eye visuals]], [[time distortion]], [[conceptual thinking]], [[introspection|enhanced introspection]], [[euphoria]], and [[ego loss]]. A study found that incubation of 1cP‐LSD with human serum led to the formation of LSD, indicating that it may act as a [[prodrug]] for LSD.<ref name="Brandt2020"></ref> Anecdotal reports appear to be consistent with this theory, with most users reporting near-identical effects as LSD. It has been reported to have a more gradual come up, along with mildly smoother cognitive and physical effects compared to 1P-LSD.
+[[Subjective effects]] include [[geometry|open and closed eye visuals]], [[time distortion]], [[conceptual thinking]], [[introspection|enhanced introspection]], [[euphoria]], and [[ego loss]]. A study found that incubation of 1cP‐LSD with human serum led to the formation of LSD, indicating that it may act as a [[prodrug]] for LSD.<ref name="Brandt2020"></ref> Anecdotal reports appear to support with this theory, with most users reporting near-identical effects as LSD. It has been reported to have a more gradual come up, along with mildly smoother cognitive and physical effects compared to LSD.
 Limited data exist on the pharmacology, metabolism, and toxicity of 1cP-LSD. While it is presumed to have a [[LSD#Toxicity and harm potential|similar risk profile as LSD]] and its analogs, which are generally thought to be safe in controlled settings, reliable scientific data is lacking. It is highly advised to use [[harm reduction practices]] if using this substance.