Diphenidine: Difference between revisions

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{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational diphenidine use do not ~~seem~~ to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because diphenidine has very little history of human usage.

The toxicity and long-term health effects of recreational diphenidine use do not appear to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because diphenidine has very little history of human usage.

~~Anecdotal evidence from those who have tried~~ diphenidine ~~suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself~~ and ~~using it sparingly (but nothing can be completely guaranteed)~~. [~~https://www~~.~~google.com/ Independent research] should always be done~~ to ~~ensure that a combination of two or more substances is safe before consumption~~.

Some anecdotal reports suggest diphenidine may increase the risk of [[mania]] and [[psychosis]]. This is common with many dissociatives, particularly with those that provide stimulation such as [[PCP]].

It has been reported that regular use can lead to increased blood pressure and rapid heart rate.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

There is some anecdotal evidence that when not used responsibly, diphenidine may have an elevated risk of inducing [[mania]]. This is common with many dissociatives, particularly with those that provide stimulation such as [[PCP]].

~~It has been found that moderate to regular use can lead to increased blood pressure and rapid heart rate, potentially leading to complications.~~

===Dependence and abuse potential===

As with other NMDA receptor antagonists, the chronic use of diphenidine can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] ~~and~~ is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if ~~a person~~ suddenly stops their usage.

As with other NMDA receptor antagonists, the chronic use of diphenidine can be considered [[Addiction potential::moderately addictive with a high potential for abuse]]. It is likely capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if one suddenly stops their usage.

Tolerance to many of the effects of diphenidine [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Diphenidine presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of diphenidine all [[dissociative]]s will have a reduced effect.

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 {{toxicity}}
 {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
-The toxicity and long-term health effects of recreational diphenidine use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because diphenidine has very little history of human usage.
+The toxicity and long-term health effects of recreational diphenidine use do not appear to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because diphenidine has very little history of human usage.
-Anecdotal evidence from those who have tried diphenidine suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+Some anecdotal reports suggest diphenidine may increase the risk of [[mania]] and [[psychosis]]. This is common with many dissociatives, particularly with those that provide stimulation such as [[PCP]].
+It has been reported that regular use can lead to increased blood pressure and rapid heart rate.
 It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
-There is some anecdotal evidence that when not used responsibly, diphenidine may have an elevated risk of inducing [[mania]]. This is common with many dissociatives, particularly with those that provide stimulation such as [[PCP]].
-It has been found that moderate to regular use can lead to increased blood pressure and rapid heart rate, potentially leading to complications.
 ===Dependence and abuse potential===
-As with other NMDA receptor antagonists, the chronic use of diphenidine can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
+As with other NMDA receptor antagonists, the chronic use of diphenidine can be considered [[Addiction potential::moderately addictive with a high potential for abuse]]. It is likely capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if one suddenly stops their usage.
 Tolerance to many of the effects of diphenidine [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Diphenidine presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of diphenidine all [[dissociative]]s will have a reduced effect.