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4-HO-MET: Difference between revisions
>Trip-banaan m "Novelty enhancement" was mentioned twice |
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{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
! Binding Sites | !Binding Sites | ||
! Binding Affinity Ki (µM)<ref name="pmid27216487">{{cite journal|last1=Rickli|first1=A.|last2=Moning|first2=O.D.|last3=Hoener|first3=M. C.|last4=Liechti|first4=M. E.|title=Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens|pmid=27216487|issn=0924-977X|oclc=795935172|volume=26|issue=8|pages=1327-1337doi=10.1016/j.euroneuro.2016.05.001|year=2016}}</ref> | !Binding Affinity Ki (µM)<ref name="pmid27216487">{{cite journal|last1=Rickli|first1=A.|last2=Moning|first2=O.D.|last3=Hoener|first3=M. C.|last4=Liechti|first4=M. E.|title=Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens|pmid=27216487|issn=0924-977X|oclc=795935172|volume=26|issue=8|pages=1327-1337doi=10.1016/j.euroneuro.2016.05.001|year=2016}}</ref> | ||
|- | |- | ||
| 5-HT<sub>1A</sub> | |5-HT<sub>1A</sub> | ||
| 0.228 | |0.228 | ||
|- | |- | ||
| 5-HT<sub>2A</sub> | |5-HT<sub>2A</sub> | ||
| 0.057 | |0.057 | ||
|- | |- | ||
| 5-HT<sub>2C</sub> | |5-HT<sub>2C</sub> | ||
| 0.141 | |0.141 | ||
|- | |- | ||
| D<sub>1</sub> | |D<sub>1</sub> | ||
| >25 | |>25 | ||
|- | |- | ||
| D<sub>2</sub> | |D<sub>2</sub> | ||
| 4 | |4 | ||
|- | |- | ||
| D<sub>3</sub> | |D<sub>3</sub> | ||
| 6.7 | |6.7 | ||
|- | |- | ||
| α<sub>1A</sub> | |α<sub>1A</sub> | ||
| 9.7 | |9.7 | ||
|- | |- | ||
| α<sub>2A</sub> | |α<sub>2A</sub> | ||
| 2.4 | |2.4 | ||
|- | |- | ||
| TAAR<sub>1</sub> | |TAAR<sub>1</sub> | ||
| 3.1 | |3.1 | ||
|- | |- | ||
| H<sub>1</sub> | |H<sub>1</sub> | ||
| 0.82 | |0.82 | ||
|- | |- | ||
| SERT | |SERT | ||
| 0.2 | |0.2 | ||
|- | |- | ||
| DAT | |DAT | ||
| >26 | |>26 | ||
|- | |- | ||
| NET | |NET | ||
| 13 | |13 | ||
|} | |} | ||
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}} | }} | ||
===Combination effects=== | ===Combination effects=== | ||
*'''[[Cannabis]]''' - When used in conjunction with cannabis, both the visual and cognitive effects of 4-HO-MET can be intensified and extended with extreme efficacy. This should be used with extreme caution, however, especially if one is not experienced with psychedelics as this can also amplify the [[anxiety]], [[confusion]] and [[psychosis]] producing aspects of cannabis significantly. | |||
*'''[[Cannabis]]''' - When used in conjunction with cannabis, both the visual and cognitive effects of 4-HO-MET can be intensified and extended with extreme efficacy. This should be used with extreme caution, however, especially if one is not experienced with psychedelics as this can also amplify the [[anxiety]], [[confusion]] and [[psychosis]] producing aspects of cannabis significantly. | |||
*'''[[Dissociatives]]''' - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] while under the influence of 4-HO-MET can result in significantly more vivid visuals than dissociatives alone present, along with more intense [[internal hallucinations]], [[confusion]], [[delusions]] and chances of a [[psychosis|psychotic reaction]]. | *'''[[Dissociatives]]''' - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] while under the influence of 4-HO-MET can result in significantly more vivid visuals than dissociatives alone present, along with more intense [[internal hallucinations]], [[confusion]], [[delusions]] and chances of a [[psychosis|psychotic reaction]]. | ||
*'''[[MDMA]]''' - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 4-HO-MET are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually. | *'''[[MDMA]]''' - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 4-HO-MET are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually. | ||
*'''[[Alcohol]]''' - This interaction is not typically recommended due to alcohol’s ability to cause [[dehydration]], which can negatively affect a trip if taken in high dosages. This combination is, however, reasonably safe in low doses and when used responsibly, this can often "take the edge off the trip" as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit more in a more stressful way on the body. | *'''[[Alcohol]]''' - This interaction is not typically recommended due to alcohol’s ability to cause [[dehydration]], which can negatively affect a trip if taken in high dosages. This combination is, however, reasonably safe in low doses and when used responsibly, this can often "take the edge off the trip" as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit more in a more stressful way on the body. | ||
*'''[[Benzodiazepines]]''' - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of a 4-HO-MET trip. With higher doses, they are very efficient at stopping [[bad trip|"bad trips"]] at the cost of reduced trip intensity and in the worst case, amnesia and blacking out. Caution is advised when acquiring them for this purpose, however, due to the very high addiction potential that benzodiazepines possess. It is generally advised to refrain from intending to use them at all unless the trip suddenly becomes completely overwhelming. | *'''[[Benzodiazepines]]''' - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of a 4-HO-MET trip. With higher doses, they are very efficient at stopping [[bad trip|"bad trips"]] at the cost of reduced trip intensity and in the worst case, amnesia and blacking out. Caution is advised when acquiring them for this purpose, however, due to the very high addiction potential that benzodiazepines possess. It is generally advised to refrain from intending to use them at all unless the trip suddenly becomes completely overwhelming. | ||
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{{#ask: [[Category:4-HO-MET]][[Category:Experience]]|format=ul|Columns=1}} | {{#ask: [[Category:4-HO-MET]][[Category:Experience]]|format=ul|Columns=1}} | ||
Additional experience reports can be found here: | Additional experience reports can be found here: | ||
* [https://www.erowid.org/experiences/subs/exp_4HOMET.shtml Erowid Experience Vaults: 4-HO-MET] | |||
*[https://www.erowid.org/experiences/subs/exp_4HOMET.shtml Erowid Experience Vaults: 4-HO-MET] | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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==Legal status== | ==Legal status== | ||
*'''Austria''': 4-HO-MET is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich). {{citation needed}} | *'''Austria''': 4-HO-MET is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich). {{citation needed}} | ||
*'''Germany''': 4-HO-MET is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MET are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref> | *'''Germany''': 4-HO-MET is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MET are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref> | ||
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*'''United Kingdom''': 4-HO-MET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref> | *'''United Kingdom''': 4-HO-MET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref> | ||
*'''United States''': 4-HO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT''), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}} | *'''United States''': 4-HO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT''), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}} | ||
*'''Poland:''' 4-HO-MET is illegal to posses, manufacture and sell under "Wykaz środków odurzających i substancji psychotropowych" (Group I-P) <ref>https://pl.wikipedia.org/wiki/Wykaz_%C5%9Brodk%C3%B3w_odurzaj%C4%85cych_i_substancji_psychotropowych#Grupa_I-P</ref> | |||
==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Research chemical]] | *[[Research chemical]] | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/4-HO-MET 4-HO-MET (Wikipedia)] | *[https://en.wikipedia.org/wiki/4-HO-MET 4-HO-MET (Wikipedia)] | ||
*[https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml 4-HO-MET (Erowid Vault)] | *[https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml 4-HO-MET (Erowid Vault)] | ||
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===Discussion=== | ===Discussion=== | ||
*[http://www.bluelight.org/vb/threads/250897-The-Big-amp-Dandy-4-HO-MET-Thread The Big & Dandy 4-HO-MET Thread (Bluelight)] | *[http://www.bluelight.org/vb/threads/250897-The-Big-amp-Dandy-4-HO-MET-Thread The Big & Dandy 4-HO-MET Thread (Bluelight)] | ||